Compound liposome containing anti-tumor drugs and preparation method and application thereof

Abstract

The invention belongs to a liposome, in particular relates to a compound liposome preparation with high targeting property of tumor tissues and efficient penetrability of tumor cells. The invention is characterized in that hyaluronic acid or sodium hyaluronate, tumor cell selective penetrating peptides and a liposome are used for together constructing a compound liposome. The compound liposome is characterized by utilizing the dual-tumor cell targeting property of the hyaluronic acid and tumor cell selective penetrating peptides to effectively solve the problem that because a conventional liposome and traditional cell penetrating peptides have no selectivity on normal cells and tumor cells, the toxicity is increased when the drug effect is increased in the therapeutic process, thereby fully meeting the clinical requirements of high efficiency and low toxicity when anti-tumor drugs are prepared into preparations for treating diseases.

Description

A kind of composite liposome containing antitumor drug and its preparation method and application Technical field: The invention belongs to the technical field of medicine, and specifically uses hyaluronic acid or sodium hyaluronate, tumor cell selective membrane-penetrating peptides and liposomes to jointly construct a composite liposome. This composite liposome is characterized by the dual tumor cell targeting of hyaluronic acid and tumor-selective membrane-penetrating peptide, which effectively solves the problem that conventional liposomes and traditional membrane-penetrating peptides have no selectivity for normal and tumor cells. The problem of increased drug efficacy and increased toxicity during treatment fully realizes the clinical needs of high efficiency and low toxicity required for the preparation of tumor drugs into preparations for treatment. Background technique: Cell-permeable peptides (CPP) are a class of polypeptides with strong cell membrane penetration...

AI Technical Summary

Problems solved by technology

Existing studies have shown that traditional membrane-penetrating peptides and ordinary liposomes (unmodified) are generally non-selective to normal tissues and tumor tissues, even active targeting liposomes have a certain amount of distribution in normal tissues, if After using traditional membrane-penetrating peptides such as R8 to modify ordinary liposomes, due to the high-efficiency membrane-penetrating properties of membrane-penetrating peptides, while increasing the amount of drugs in tumor cells, it must be accompanied by a corresponding increase in the amount of drugs in normal cells. Will cause greater damage to normal cells and tissues (significantly increased toxic side effects)

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