Real-time contemporaneous multimodal imaging and spectroscopy uses thereof

A spectroscopic and imaging technology, applied in the fields of spectral diagnosis, optical radiation measurement, Raman/scattering spectroscopy, etc.

Inactive Publication Date: 2006-07-12
PERCEPTRONIX MEDICAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0027] The present invention solves the problems described above by

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  • Real-time contemporaneous multimodal imaging and spectroscopy uses thereof
  • Real-time contemporaneous multimodal imaging and spectroscopy uses thereof
  • Real-time contemporaneous multimodal imaging and spectroscopy uses thereof

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Embodiment Construction

[0037] While the present invention can be affected by different forms of examples, the specific examples shown in the drawings are described in detail here, and it is understood that the disclosure of the present invention can be considered as a principle example of the present invention, and does not limit the present invention illustrated and described herein. invention.

[0038] Endoscopes and endoscopic systems can be described and differentiated in terms of tissue luminescence and signals generated, including reflected and / or emitted light spectra.

[0039] figure 1 (Prior Art) illustrates typical spectra utilized for white light and fluorescence evaluation. Spectrum 0100 shows a broad range of luminescence typically utilized. This emission can be provided by a single light source or by multiple combined light sources as discussed further in the prior art and in this application.

[0040] Spectrum 1101 shows a typical white light (broadband) luminescence spectrum. Va...

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Abstract

The present invention comprises an optical apparatus, methods and uses for real-time (video-rate) multimodal imaging, for example, contemporaneous measurement of white light reflectance, native tissue autofluorescence and near infrared images with an endoscope. These principles may be applied to various optical apparati such as microscopes, endoscopes, telescopes, cameras etc. to view or analyze the interaction of light with objects such as planets, plants, rocks, animals, cells, tissue, proteins, DNA, semiconductors, etc. Multi-band spectral images may provide morphological data such as surface structure of lung tissue whereas chemical make-up, sub-structure and other object characteristics may be deduced from spectral signals related to reflectance or light radiated (emitted) from the object such as luminescence or fluorescence, indicating endogenous chemicals or exogenous substances such as dyes employed to enhance visualization, drugs, therapeutics or other agents. Accordingly, one embodiment of the present invention discusses simultaneous white light reflectance and fluorescence imaging. Another embodiment describes the addition of another reflectance imaging modality (in the near-IR spectrum). Input (illumination) spectrum, optical modulation, optical processing, object interaction, output spectrum, detector configurations, synchronization, image processing and display are discussed for various applications.

Description

technical field [0001] Various optical devices such as microscopes, endoscopes, telescopes, cameras, etc. support the observation or analysis of light interactions with objects such as planets, plants, rocks, animals, cells, tissues, proteins, DNA, semiconductors, etc. Some multi-band spectral images provide morphological image data, but other multi-band spectral images provide information related to chemical makeup, substructure, and / or other properties of target objects that can be determined from reflected or emitted light multi-band spectral images . These light emission images, such as luminescence or fluorescence, can indicate and provide a means of assessing endogenous chemicals or exogenous substances such as stains used to enhance visualization, drugs, therapeutic agents or other agents. [0002] In the field of medical imaging and more specifically endoscopy, reflected white light, natural tissue autofluorescence, luminescence, chemiluminescence, near-IR reflectance...

Claims

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Application Information

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IPC IPC(8): A61B5/00
CPCA61B1/0676A61B5/0071A61B1/043A61B5/0084A61B1/0646A61B1/0684A61B5/0075G01J3/2803G01J3/32G01J3/36G01J3/4406G01J2003/1213
Inventor 曾海山米里扬·佩泰克布兰科·帕尔契奇加里·W·弗格森
Owner PERCEPTRONIX MEDICAL
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