Suspension preparation of temperature change painless nano sulfadiazine metallic compound hyaluronic acid

A metal compound, sulfadiazine technology, applied in the field of sulfadiazine metal compounds, can solve the problems of difficult control of dosage, insufficient moisturizing ability of wound surface, and short duration of drug effect, so as to prolong the action time in the body, promote healing and wound healing. Restorative and healing effects

Active Publication Date: 2014-09-03
LIPONT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the clinically used sulfadiazine silver and sulfadiazine zinc preparations are mainly creams, ointments, powders, and suspensions that are currently prepared and used in clinical practice. These preparations have certain defects, such as: drug penetration Poor ability, insufficient wound moisturizing ability, strong irritation during administration, short duration of drug effect, difficult to control the dosage, excessive local drug may cause skin rash, dermatitis, muscle pain and even subtoxicity and many other problems

Method used

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  • Suspension preparation of temperature change painless nano sulfadiazine metallic compound hyaluronic acid
  • Suspension preparation of temperature change painless nano sulfadiazine metallic compound hyaluronic acid
  • Suspension preparation of temperature change painless nano sulfadiazine metallic compound hyaluronic acid

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Effect test

preparation example Construction

[0190] 1. Preparation of test bacterial suspension: inoculate Escherichia coli K88 and Streptococcus strains on LB medium, incubate at 37°C for 24 hours, pick single bacteria into 3ml LB liquid medium with inoculation loop, 37°C, 200r / min Shake culture to prepare bacterial suspension;

[0191] 2. Antibacterial test sample preparation: prepare a filter paper sheet with a diameter of 7mm, sterilize it with ultraviolet radiation, and apply samples of different formulations on the filter paper sheet according to the table below under the ultra-clean workbench;

[0192] The application dosage is shown in the table below:

[0193]

[0194] 3. Comparison of antibacterial properties of samples with different particle sizes: Aseptic operation, take 100 μL of bacterial suspension and spread evenly on LB / SS plate, after standing for about 30 minutes, put a wound dressing with a diameter of 7 mm on the plate, and filter paper for antibacterial test samples Place the slices on the plat...

Embodiment 1

[0218] Preparation method: ball milling method, the preparation volume is 30g.

[0219] prescription:

[0220]

Embodiment 2

[0222] Preparation method: ball milling method, the preparation volume is 30g

[0223] prescription:

[0224]

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Abstract

The invention discloses a suspension preparation of temperature change painless nano sulfadiazine metallic compound hyaluronic acid. The formula comprises a sulfadiazine metallic compound, a hyaluronic acid substance, an analgetic, a dispersing agent aid, a suspension aid and water, wherein the sulfadiazine metallic compound comprises sulfadiazine silver and sulfadiazine zinc; the hyaluronic acid substance is sourced from biological fermentation and animal tissue extraction and the like and can be hyaluronic acid or hyaluronate or crosslinked hyaluronic acid or crosslinked hyaluronate; the analgetic comprises ropivacaine, bupivacaine, levobupivacaine, lidocaine and other local anesthetics or combination of the local anesthetics; the dispersing agent aid comprises chlorhexidine, Tween series, oleic acid or sodium oleate; the suspension aid can comprise glycerinum, celluloses, poloxamer series and hyaluronic acid substances. The suspension preparation is mainly used for burn, scald or the surface of a wound caused by explosion or anabrosis, has the main clinical characteristics that pain is rapidly relieved, the surface of the wound is subjected to rapid film formation and rapid healing of the wound is promoted, and the conventional main administration modes refer to spraying, smearing and coating.

Description

technical field [0001] The invention relates to a class of sulfadiazine metal compounds, especially the formulation of temperature-variable painless nanometer sulfadiazine silver or sulfadiazine zinc hyaluronic acid suspension preparation. The painless nanometer sulfadiazine metal compound hyaluronic acid suspension preparation is mainly used It is used for recovery treatment of open wounds caused by burns, scalds, explosions and mechanical injuries such as abrasions. Background technique [0002] Burns, scalds, explosions or mechanical injuries cause the skin surface to be damaged and lose its ability to protect tissues, creating convenient conditions for bacterial infection, and the exudation of a large amount of interstitial fluid provides a good environment for bacterial proliferation. If the treatment of the injured part is not timely, it will easily lead to a series of pathophysiological changes of the wound, making the injury more complicated and serious, thus increas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K45/00A61K31/635A61K47/36A61P17/02A61K31/728
Inventor 余惟平卢伍党陈涛孔丹凤
Owner LIPONT PHARMA
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