Compound transdermal patch used for curing acute and chronic inflammatory pain

A transdermal patch, acute and chronic inflammation technology, applied in the field of compound transdermal patch, can solve the problems of insignificant effect, low drug concentration, short curative effect, etc. Effect

Inactive Publication Date: 2009-09-16
中山健康基地孵化器管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Acute and chronic pain is a common disease. At present, the treatment of various acute and chronic pains is mainly based on oral non-steroidal anti-inflammatory drugs, but oral non-steroidal anti-inflammatory drugs have serious irritation to the gastrointestinal tract, and the cu

Method used

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  • Compound transdermal patch used for curing acute and chronic inflammatory pain
  • Compound transdermal patch used for curing acute and chronic inflammatory pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The compound transdermal patch of the invention contains the following components in mass percent: 1% lidocaine, 15% diclofenac sodium, 8% compound penetration enhancer and 76% hydrophilic polymer pressure-sensitive adhesive.

[0042] Wherein the preparation method of the present invention is as follows:

[0043] Mix 8% of the compound penetration enhancer, 1% of lidocaine and 15% of diclofenac sodium, wherein the compound penetration enhancer of this embodiment adopts the concentration of 2% azone and the concentration of 3% lauryl alcohol and 3% Ethanol, grind the above substances evenly, ultrasonically dissolve, then add 76% hydrophilic acrylate copolymer emulsion, stir evenly, ultrasonically remove air bubbles, apply on release paper, dry, cover polyethylene film, cut, seal After packaging, the compound transdermal patch of the present invention is obtained.

Embodiment 2

[0045] The compound transdermal patch of the invention contains the following components in mass percent: 20% lidocaine hydrochloride, 5% diclofenac sodium, 20% compound penetration enhancer and 55% hydrophilic polymer pressure-sensitive adhesive.

[0046] Wherein the preparation method of the present invention is as follows:

[0047] Mix 20% of the composite penetration enhancer, 20% of lidocaine hydrochloride and 5% of diclofenac sodium, wherein the composite penetration enhancer of this embodiment uses a mixture of azone, propylene glycol, oleic acid and menthol, and grinds the above-mentioned substances Uniform, ultrasonically dissolved, then add 55% of the pressure-sensitive adhesive matrix hydrophilic acrylate copolymer emulsion, grind evenly, degas the air, apply it on the release paper, dry, cut, and pack to obtain the compound transdermal patch of the present invention piece.

Embodiment 3

[0049] The compound transdermal patch of the invention contains the following components in mass percent: 10% lidocaine, 20% diclofenac potassium, 10% compound penetration enhancer and 60% hydrophilic polymer pressure-sensitive adhesive.

[0050] Wherein the preparation method of the present invention is as follows:

[0051] Mix 10% of the compound penetration enhancer, 10% of lidocaine and 20% of diclofenac potassium, wherein the composite penetration enhancer of this embodiment adopts the mixture of lipoacetate, azone, Tween 80, and lauryl alcohol. The above-mentioned substances are ground uniformly, ultrasonically dissolved, and then 60% of the pressure-sensitive adhesive matrix hydrophilic acrylate copolymer emulsion is added, ground uniformly, degassed, coated on release paper, dried, cut, and packaged to obtain the compound of the present invention Transdermal patch.

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Abstract

The invention discloses a compound transdermal patch used for curing acute and chronic inflammatory pain. The patch comprises a compound penetrating agent and a pressure sensitive adhesive and is characterized by also comprising Xylocaine or hydrochloride thereof and sodium salt or sylvite of diclofenac. The transdermal patch contains the following components by weight percentages: 1-20 percent of Xylocaine or the hydrochloride thereof, 1-20 percent of the sodium salt or sylvite of diclofenac, 1-30 percent of compound penetrating agent and 40-49 percent of pressure sensitive adhesive. Aiming at overcoming the defects of the existing medicinal preparations in treatment and use, the invention provides a compound transdermal patch that is used for curing acute and chronic inflammatory pain, can act on local human body and quickly permeate, and is good in treatment effect, safe and convenient in use.

Description

technical field [0001] The present invention relates to a kind of compound transdermal patch that is used for the treatment of acute and chronic inflammatory pain, more specifically, the present invention relates to a kind of compound transdermal patch that is composed of two main components lidocaine or its hydrochloride and diclofenac sodium salt or potassium Compound lidocaine transdermal patch for the treatment of acute and chronic inflammatory pain with combined application of salt. Background technique [0002] Acute and chronic pain is a common disease. At present, the treatment of various acute and chronic pains is mainly based on oral non-steroidal anti-inflammatory drugs, but oral non-steroidal anti-inflammatory drugs have serious irritation to the gastrointestinal tract, and the curative effect Short, the effect is not obvious, especially some local pain, oral medicine reaches the local pain site drug concentration is low, so that the effect is not obvious, so it ...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K9/00A61K31/4164A61K31/167A61P29/00
Inventor 余从洪温锦涛赵娜
Owner 中山健康基地孵化器管理有限公司
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