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Compound lignocaine emulsifiable paste and preparing technique

A technique for lidocaine and its preparation process, which is applied in the field of compound lidocaine cream and its preparation process, can solve the problems of slow transdermal absorption rate, etc., achieve increased transdermal absorption rate, reasonable formula and process, and meet large-scale industrialization The effect of production

Inactive Publication Date: 2008-07-02
SHANGHAI FOSUN PHARMA (GROUP) CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] The technical problem to be solved by the present invention is to overcome the slow problem of the original prescription transdermal absorption rate, research and design the production process of the compound lidocaine emulsifiable paste that is more suitable for clinical use

Method used

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  • Compound lignocaine emulsifiable paste and preparing technique
  • Compound lignocaine emulsifiable paste and preparing technique
  • Compound lignocaine emulsifiable paste and preparing technique

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0050] Recipe: Lidocaine 25g

[0051] Prilocaine 25g

[0052] Carbomer 934 11g

[0053] Azone 32g

[0054] Tween--80 20g

[0055] 10% sodium hydroxide aqueous solution 7g

[0056] Add purified water to 1000g

[0057] Process steps:

[0058] 1) Weigh the formula amount of lidocaine and prilocaine, stir in a water bath at 30-45°C until they melt into a uniform transparent liquid, i.e. eutectic, and set aside;

[0059] 2) Take the formula amount of Carbomer 934 and add 95% of the total formula in purified water, stir to make it fully swell, stir evenly to form a transparent colloid, and adjust the pH value of the colloid to 8-10 with 10% sodium hydroxide aqueous solution;

[0060] 3) Transfer the above-mentioned colloid to the emulsification pot, add the formula amount of Tween-80, stir evenly, add the formula amount of eutectic and azone, and stir until the emulsification is uniform;

[0061] 4) Measure the pH value to make it 8-10, add purified water to the formula amoun...

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Abstract

The invention provides a compound lidocaine cream and the preparation technique. The invention selects a new cream formulation and technique. The product which is prepared by the technique has stable quality, the formulation and the technique are reasonable and stable, and the method overcomes the shortcomings of the original technique and can meet the needs of industrial large-scale production. The product of the invention can shorten the anesthesia time when in clinical use, thus greatly reducing the waiting time of the patients and being much easier to be accepted by the patients.

Description

Technical field: [0001] The invention belongs to the technical field of pharmaceutical preparations. It specifically relates to compound lidocaine cream and a preparation process. Background technique: [0002] Compound lidocaine cream is a compound cream prepared from two local anesthetics, lidocaine and prilocaine. Abroad, it was first listed in the 1980s by the Swedish company Astra (trade name EMLA), and now it has been listed in more than a dozen countries including China and the United States. The drug is mainly aimed at the problem that existing anesthetics (including injections, latex and solutions) are difficult to penetrate the stratum corneum and epidermis of the intact skin, enter the dermis where the nerve endings that feel pain are located, and exert an analgesic effect. An effective topical anesthetic capable of penetrating intact skin. [0003] Advantages and applications [0004] The main advantages of this drug are: [0005] 1. Small irritation to tiss...

Claims

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Application Information

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IPC IPC(8): A61K31/167A61K9/06A61K47/34A61P23/02A61K47/14
Inventor 周建伟王燕熊洁
Owner SHANGHAI FOSUN PHARMA (GROUP) CO LTD
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