Preparation method of carboxymethyl chitosan quaternary ammonium salt/organic rectorite nano composite material and application thereof

A technology of carboxymethyl chitosan and nano-composite material, which is applied in the field of carboxymethyl chitosan quaternary ammonium salt/organic rectorite nano-composite material and its preparation, can solve the problems such as nano-composite materials that have not yet appeared, and achieves Excellent water solubility, widened application range, and improved heat resistance

Inactive Publication Date: 2010-08-25
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nanocomposites combining carboxymethyl chitosan quaternary ammonium salt and organic rectorite have not yet appeared in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: with 0.05g carboxymethyl chitosan quaternary ammonium salt (weight-average molecular weight is 4.1 * 10 5 , the degree of carboxymethyl substitution is 70%, the degree of substitution of quaternary ammonium salt is 75%) to prepare a 0.1g / ml aqueous solution, add dropwise to 0.1g 1g / ml organic rectorite suspension, and react at 80°C for 1.5d , then add 0.05g 0.5g / ml carboxymethyl chitosan quaternary ammonium salt aqueous solution, continue to stir for 1d, and freeze-dry to obtain carboxymethyl chitosan quaternary ammonium salt / organic rectorite nanocomposite material. Carboxymethyl chitosan quaternary ammonium salt. The total weight percentage of each component of the composite material is 50% of carboxymethyl chitosan quaternary ammonium salt and 50% of organic rectorite. The interlayer spacing of rectorite in the composite is 4.62nm.

[0013] Make sodium alginate into 0.5mg / ml aqueous solution, add dropwise to 0.3mg / ml calcium chloride aqueous solution,...

Embodiment 2

[0014] Embodiment 2: with 0.1g carboxymethyl chitosan quaternary ammonium salt (weight-average molecular weight is 3.5 * 10 5 , the degree of carboxymethyl substitution is 50%, the degree of substitution of quaternary ammonium salt is 90%) to prepare a 0.15g / ml aqueous solution, add dropwise to 0.1g 1.5g / ml organic rectorite suspension, and react at 75°C for 1d , and then add 0.1 g of 0.75 g / ml carboxymethyl chitosan quaternary ammonium salt solution, continue to stir for 1.5 days, and freeze-dry to obtain carboxymethyl chitosan quaternary ammonium salt / organic rectorite nanocomposite material. The total weight percentage of each component of the composite material is 66.7% of carboxymethyl chitosan quaternary ammonium salt and 33.3% of organic rectorite. The interlayer spacing of rectorite in the composite is 4.72nm.

[0015] Make sodium alginate into 0.8mg / ml aqueous solution, add it dropwise into 0.5mg / ml calcium chloride aqueous solution, stir for 0.75h, and then add drop...

Embodiment 3

[0016] Embodiment 3: with 0.1g carboxymethyl chitosan quaternary ammonium salt (weight-average molecular weight is 3.8 * 10 5 , the degree of carboxymethyl substitution is 60%, the degree of substitution of quaternary ammonium salt is 85%) to prepare a 0.2g / ml aqueous solution, add dropwise to 0.1g 1.5g / ml organic rectorite suspension, and react at 80°C for 2d , then add 0.3g 1g / ml carboxymethyl chitosan quaternary ammonium salt aqueous solution, continue to stir for 1.5d, and freeze-dry to obtain carboxymethyl chitosan quaternary ammonium salt / organic rectorite nanocomposite material. The total weight percentage of each component of the composite material is 80% of carboxymethyl chitosan quaternary ammonium salt and 20% of organic rectorite. The interlayer spacing of rectorite in the composite is 4.41nm.

[0017] Make sodium alginate into 1.0mg / ml aqueous solution, add dropwise to 0.5mg / ml calcium chloride aqueous solution, stir for 1h, and then add dropwise to the carboxyme...

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Abstract

The invention provides a preparation method of a carboxymethyl chitosan quaternary ammonium salt/organic rectorite nano composite material and an application thereof. The carboxymethyl chitosan quaternary ammonium salt/organic rectorite nano composite material comprises the basis components of carboxymethyl chitosan quaternary ammonium salt and organic rectorite, and is generated by intercalating the carboxymethyl chitosan quaternary ammonium salt layer between the organic rectorite layers, wherein the distance between the intercalated organic rectorite layers is 4.2-4.72 nm. The preparation method comprises the following steps: dropwise adding the carboxymethyl chitosan quaternary ammonium salt solution of a certain concentration to the organic rectorite aqueous suspension under the condition of stirring at 70-80 DEG C, and then freezing and drying to obtain the nano composite material carboxymethyl chitosan quaternary ammonium salt/organic rectorite. The nano composite material can be used as a drug carrier, has the advantages of both the carboxymethyl chitosan quaternary ammonium salt and the organic rectorite, the drug control-release capability of the nano composite material is superior to that of the single carboxymethyl chitosan quaternary ammonium salt, and the heat resistance of the nano composite material is also significantly improved compared with that of the carboxymethyl chitosan quaternary ammonium salt.

Description

technical field [0001] The invention relates to a carboxymethyl chitosan quaternary ammonium salt / organic rectorite nanocomposite material used as a drug carrier and a preparation method thereof. Background technique [0002] Carboxymethyl chitosan quaternary ammonium salt is an amphoteric polymer that simultaneously introduces carboxymethyl and quaternary ammonium salt groups on the chitosan molecular chain. It has a structure similar to biopolymers such as proteins and nucleic acids. High biological adaptability, which has attracted widespread attention in the field of biomedicine. Researches in the prior art have shown that it has better ability to control the drug release, but the encapsulation rate and sustained release effect of the drug are not very satisfactory. Layered silicate minerals have adhesive properties, which can be dispersed in submicron particles in aqueous solution, low in price, large in specific surface area, strong in adsorption capacity and good in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36
Inventor 王小英刘博孙润仓
Owner SOUTH CHINA UNIV OF TECH
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