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Anti-infection PMMA (polymethyl methacrylate) bone cement for composite chitosan quaternary ammonium salt

A technology of chitosan quaternary ammonium salt and bone cement, applied in medical science, prosthesis, etc., to slow down adjacent vertebral fractures, avoid antibiotic resistance, and slow down premature degeneration

Inactive Publication Date: 2011-10-19
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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But about the anti-infective PMMA bone cement of composite chitosan quaternary ammonium salt (HACC) there is no report yet

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  • Anti-infection PMMA (polymethyl methacrylate) bone cement for composite chitosan quaternary ammonium salt
  • Anti-infection PMMA (polymethyl methacrylate) bone cement for composite chitosan quaternary ammonium salt
  • Anti-infection PMMA (polymethyl methacrylate) bone cement for composite chitosan quaternary ammonium salt

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[0025] 1. Materials and methods

[0026] (1) Experimental materials and instruments

[0027] Materials: Ordinary bone cement: polymethyl methacrylate (PMMA) and bone cement loaded with gentamicin (PMMA-G, DePuy International Ltd.UK), containing 40g of powder and 20ml of liquid; Every 40g of cement powder contains 2g of gentamicin. HACC (chitosan quaternary ammonium salt). High-purity chitosan (deacetylation degree 91.83%, viscosity average molecular weight 200,000, purchased from Zhejiang Jinke Biochemical Co., Ltd.). TSB (TSA) medium or plates. Live / Dead staining solution (LIVE / DEAD Baclight bacteria viability kits, Molecular probes, L13152): Take 1 tube each of SYT09 and PI and add 5ml sterile dh 2 o In water, mix well and store at -20°C. Phosphate buffer. Experimental strains: Staphylococcus epidermidis strain (S. epidermidis), methicillin-resistant Staphylococcus epidermidis strain (MRSE) and Staphylococcus epidermidis strain (ATCC 35984) purchased from the American ...

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Abstract

The invention relates to an anti-infection PMMA (polymethyl methacrylate) bone cement for composite chitosan quaternary ammonium salt. The composite bone cement is prepared by mixing HACC, PMMA and bone cement monomers, wherein the mass ratio of the HACC and the PMMA is 15-30%. The invention also provides a preparation method and applications for the composite bone cement. The invention has the advantages that the PMMA of the composite HACC can replace the current frequently-used PMMA antibiotic bead chain, can be applied to bone defect filling, infection prevention, treatment of chronic osteomyelitis and centrum reinforcement of osteoporosis, achieves the antimicrobial activity similar to the antibiotic bone cement, simultaneously avoids the generation of antibiotic resistance, can be used for patients with resistance to antibiotics, and has larger clinical application values; and appropriate reduction of elastic modulus is also beneficial to reducing the non-uniform stress distribution of a cured centrum and an adjacent centrum section, thus relieving the early degeneration of adjacent intervertebral disk and fracture of adjacent centrums.

Description

technical field [0001] The invention relates to a medical bone cement composite material, in particular to an anti-infection PMMA bone cement compounded with chitosan quaternary ammonium salt. Background technique [0002] With the increase of the aging population, the extension of life expectancy and the improvement of the quality of life, total knee and total hip arthroplasty and PVP (PKP) technology for the treatment of osteoporotic spinal compression fractures are increasingly widely used in orthopedic clinics. In these operations, polymethyl methacrylate (PMMA) is the most commonly used implant fixation material, which can achieve immediate and reliable fixation of joint prostheses and fracture ends. Like other implant materials, PMMA will also increase the risk of infection due to bacterial invasion and biofilm formation on its surface. Clinically, after primary total hip and total knee replacement, the incidence of deep infection is as high as 1%-2%, while joint revi...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/16A61L27/54
Inventor 谭红略汤亭亭彭兆祥郭圣荣
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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