Hydroxyapatite-zirconium dioxide composite bioceramic material and its preparing method

A composite bioceramic and hydroxyapatite technology, applied in the field of biomedical material preparation, to achieve good immune compatibility, improve comprehensive performance, and light activation

Inactive Publication Date: 2005-12-21
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the composite ceramic material prepared by this mixed sintering method has a flexural strength of 160-310MPa, K 1C 1.0~3.0MPa·m 1 / 2 , can not be used as human body load-bearing implants in parts of the human body with heavy load

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The HA-ZrO of this embodiment 2 The preparation process and steps of the simple composite bioceramic material are as follows:

[0026] (1) Preparation of 3% mol Y 2 o 3 Partially stabilized ZrO 2 Powder: Y as specified 2 o 3 / ZrO 2 Ratio ingredients, weigh analytically pure Y 2 o 3 6.78g, dissolved in hydrochloric acid of 36% concentration; Weigh zirconium oxychloride ZrOCl containing water of crystallization 2 ·8H 2 O 340g, be dissolved in deionized water, all make the solution of 0.2mol / L. Mix the two solutions and stir evenly; dilute 25% commercial ammonia water 10 times with deionized water, then slowly add ammonia water to the above mixed solution, and keep stirring to keep the pH value of the system greater than 9.5; let it stand for precipitation to obtain Co-precipitate; filter and wash the coprecipitate to remove chloride ions, make chloride ions 2 O, make H 2 The O content is less than 4 vol%, and the loose hydroxide precursor is obtained after dry...

Embodiment 2

[0032] The HA-ZrO of this embodiment 2 The preparation process and steps of the gradient composite bioceramic material are as follows:

[0033] (1) Preparation of 3% mol Y 2 o 3 Partially stabilized ZrO 2 Powder (this step is exactly the same as that described in Example 1 above).

[0034] (2) Preparation of hydroxyapatite (abbreviated as HA) powder (this step is exactly the same as that described in the above-mentioned Example 1).

[0035] (3) in the prepared ZrO 2 Add 1.5wt% polyvinyl alcohol PVA to the powder of HA and HA respectively, and granulate through spray drying.

[0036] (4) Tiling each material powder layer in the steel mold; 2 The upper and lower surfaces of the central layer of the matrix are respectively symmetrically laid on the surface layer of pure HA powder - 50wt% HA + 50wt% ZrO 2 -30wt%HA+70wt%ZrO 2 -10wt%HA+90wt%ZrO 2 Mixed powder middle layer, a total of three middle layers; followed by dry pressing at a pressure of 15MPa, and then pressureless...

Embodiment 3

[0039] The HA-ZrO of this embodiment 2 The preparation process and steps of the simple composite bioceramic material are as follows:

[0040] (1) Preparation mixed with 3% mol Y 2 o 3 ZrO 2 powder:

[0041] This step is exactly the same as the content of the above-mentioned embodiment 1.

[0042] (2) Preparation of hydroxyapatite (abbreviated as HA) powder:

[0043] This step is exactly the same as in Example 1 above.

[0044] (3) In the prepared ZrO 2 Add 1.5wt% polyvinyl alcohol PVA to the powder of HA and HA respectively, and granulate after spray drying.

[0045] (4) Preparation of HA-ZrO 2 Simple composite bioceramic materials:

[0046] This step is exactly the same as the above-mentioned Example 1, the difference is: dry pressing at a pressure of 25 MPa, and then pressureless sintering at a high temperature of 1500 ° C to finally obtain HA-ZrO 2 Simple composite bioceramic material.

[0047] After testing, the average flexural strength of the simple composite ...

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Abstract

The invention relates to a kind of hydroxyl apatite - zirconia compound biology ceramic material and its producing method, belonging to biology medical material producing technological field. The invention makes zirconia as substance central layer, on its upper and lower surfaces, respectively spread mix middle layer of zirconia and hydroxyl apatite mixed as per different proportion, on the most outside spread a surface layer of pure hydroxyl apatite, to form a kind of gradient nappe structure; in steel mould, at pressure of 10 - 30 MPa, dry press to molding, then at high temperature of 1500 - 1600 Deg. C, sinter without pressure, then can get hydroxyl apatite - zirconia compound biology ceramic material. The compound material produced by the method of the invention, its anti-bending strength is 900 - 1100 MPa, its fracture toughness (KIC) is 7 - 10 MPaíñm1/2, its roughness is 0.5 - 5.0 micron; the compound material has good biology compatibility, so can meet the requirement of load bearing planting body of different parts of human body.

Description

technical field [0001] The invention relates to a hydroxyapatite-zirconia composite bioceramic material and a preparation method thereof, belonging to the technical field of preparation of biomedical materials. Background technique [0002] Hydroxyapatite (HA), which has similar chemical composition and structure to human hard tissue, has good biological activity, but its mechanical properties are poor, low strength, poor toughness, such as bending strength of 50-150MPa, fracture toughness (K 1C ) not exceeding 1.0MPa·m 1 / 2 , while the human skeleton is at 2~12MPa·m 1 / 2 . Therefore, as an artificial implant, that is, a bone replacement material, the reliability of its use is poor. [0003] Zirconia (ZrO 2 ), has good wear resistance and biocorrosion resistance. Therefore, its mechanical properties are superior to other ceramic materials. According to test reports, doped with 3mol% Y 2 o 3 ZrO 2 Ceramic, that is, 3mol% Y 2 o 3 Partially stabilized ZrO 2 The flexu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/48
Inventor 吴晓春汪宏斌张敏
Owner SHANGHAI UNIV
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