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Preparation method of gradient porous bioceramic scaffold

A bioceramic, gradient porous technology, applied in medical science, prosthesis, etc., can solve the problems of weak bearing capacity of porous ceramic stents, difficult to customize production for patients, etc., and achieve the effect of improving bearing capacity

Active Publication Date: 2010-04-07
西安点云生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to overcome the disadvantages of weak load-carrying capacity of porous ceramic stents in the prior art and difficulty in customized production according to individual patient differences, the present invention provides a preparation method of gradient porous bioceramic stents. The method adopts the principle of bionics to design a relatively dense exterior and a directional interior. Arranged layered porous structure, this gradient pore structure can not only ensure the transport of nutrients inside the artificial bone scaffold, but also improve the overall bearing capacity of the bioceramic scaffold, and can realize moldless manufacturing

Method used

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  • Preparation method of gradient porous bioceramic scaffold
  • Preparation method of gradient porous bioceramic scaffold
  • Preparation method of gradient porous bioceramic scaffold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1.1) 5% dextrin by mass percentage is mixed with 95% hydroxyapatite bioceramic powder by mass percentage, and deionized water is added according to the solid-liquid ratio of 1:2 to make ceramic slurry, and the ceramic The slurry is placed in a ball mill tank, ball milled for 8 hours and mixed evenly, after drying, the bioceramic powder mixture with a diameter of less than 200 μm is screened out with an 80-mesh sieve for later use;

[0036] (1.2) Use computer-aided design software to design a shell shape drawing with one end closed and the other open;

[0037] (1.3) Use the bioceramic powder mixture obtained in step (1.1) as a raw material, use deionized water as a bonding aid, and use a 3D printer to print out a 3D shell according to the shell-shaped solid model designed in step (1.2). , after the water is dry, take out the three-dimensional shell, and clean up the excess powder that is not bonded in the three-dimensional shell.

[0038] (1.4) Adopt the polyvinyl alco...

Embodiment 2

[0042] (2.1) The dextrin of 15% by mass percentage is mixed with the tricalcium phosphate bioceramic powder of 85% by mass percentage, and according to the solid-liquid ratio of 1:2, add deionized water to make ceramic slurry, this ceramic slurry The material is placed in a ball mill tank, and ball milled for 12 hours to mix evenly. After drying, a bioceramic powder mixture with a diameter of less than 200 μm is screened out with an 80-mesh sieve for subsequent use;

[0043] (2.2) Use computer-aided design software to design a shell shape drawing with one end closed and the other open;

[0044] (2.3) Using the bioceramic powder mixture obtained in step (2.1) as a raw material, using deionized water as a bonding aid, and according to the shell-shaped solid model designed in step (2.2), use a 3D printer to print out a 3D shell , after the water is dry, take out the three-dimensional shell, and clean up the excess powder that is not bonded in the three-dimensional shell.

[0045...

Embodiment 3

[0049] (3.1) 10% by mass percentage of dextrin is mixed with 90% by mass percentage of silicon nitride bioceramic powder, and deionized water is added according to a solid-liquid ratio of 1:2 to make a ceramic slurry, and the ceramic slurry The material is placed in a ball mill tank, and ball milled for 10 hours to mix evenly. After drying, a bioceramic powder mixture with a diameter of less than 200 μm is screened out with a 80-mesh sieve for subsequent use;

[0050] (3.2) Use computer-aided design software to design a shell shape drawing with one end closed and the other open;

[0051] (3.3) Use the bioceramic powder mixture obtained in step (3.1) as a raw material, use deionized water as a bonding aid, and use a 3D printer to print out a 3D shell according to the shell-shaped solid model designed in step (3.2). , after the water is dry, take out the three-dimensional shell, and clean up the excess powder that is not bonded in the three-dimensional shell.

[0052] (3.4) Usi...

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Abstract

The invention discloses a preparation method of gradient porous bioceramic scaffold. The method adopts the steps of preparing three-dimensional shells, pouring bioceramic slurry, freeze-drying and sintering to prepare porous bioceramic scaffold with relatively dense structure in the exterior and directional layered porous structure in the interior. The average flexural strength of the shell material reaches 28.5-35.6MPa; in addition, the porous bioceramic scaffold prepared by the method of the invention can be customized according to the individual differences of patients without relying on moulds for shaping and the invention is characterized by fast production; and the gradient porous bioceramic scaffold can be used in the field that artificial bone is used to repair pathological or injured bone tissues.

Description

technical field [0001] The invention relates to a preparation method of a porous bioceramic support, in particular to a preparation method of a bioceramic support with a gradient porous structure. Background technique [0002] Bone is the load-carrying tissue of the human body. For bone tissue with disease or damage, natural bone, such as body bone, allogeneic bone, xenogeneic bone or artificial bone can be used for repair. Artificial bone can be designed, produced on demand and easy to standardize, so as to solve various problems of bone repair in a long-lasting and effective way. In order to ensure the transport of bone cells and nutrients in the scaffold and promote the growth of new bone, artificial bone often needs to be made into a porous structure. However, the porous structure will reduce the mechanical properties of the material. The actual human bone has a gradient pore structure that is dense and tough on the outside (called compact bone) and loose and porous on...

Claims

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Application Information

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IPC IPC(8): A61L27/10A61L27/56
Inventor 曾庆丰张立同闫秀天成来飞刘永胜汪焰恩宋佳音栾新刚江润坤陆红亚周岩姜凝
Owner 西安点云生物科技有限公司
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