Implantable medical devices made from polymer-bioceramic composite

Inactive Publication Date: 2007-12-06
ABBOTT CARDIOVASCULAR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0019] Certain other embodiments of the present invention include a method of fabricating an implantable medical device comprising: subjecting a mixture of bioceramic particles and polymer to high sheer stress using twin-screw extruder or a batch mixer; forming a composite including the bioceramic particles dispersed within a polymer, the mechanical smash, reducing the agglomeration of the bioceramic particles during the formation; and fabricating an implantable medical device from the composite.
[0020] Some embodiments of the present invention include a method of fabri

Problems solved by technology

A potential problem with polymeric stents is that their struts or bar arms can crack during crimping and expansion.
The localized porti

Method used

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  • Implantable medical devices made from polymer-bioceramic composite
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  • Implantable medical devices made from polymer-bioceramic composite

Examples

Experimental program
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Effect test

example 1

Prophetic Example of Solution Blending of Polymer and Bioceramic Particles

[0159] Step 1: Add bioceramic particles into suitable solvent, such as chloroform, acetone, etc. and stir to form a bioceramic particle suspension solution.

[0160] Step 2: Slowly add a polymer such as PLLA, PDLLA, PLGA into suspension solution and stir until polymer dissolves completely. In this step, the solution may still have a relatively low viscosity. However, the bioceramic particles should be well dispersed while stirring.

[0161] Step 3: Slowly add the polymer into solution again to gradually increase solution viscosity. Repeat this step as needed until the polymer is completely dissolved and reasonable solution viscosity is developed.

[0162] Step 4: Apply ultrasonic mixing to suspension solution for 15-30 min to further disperse all the HAP uniformly into the PLLA solution.

[0163] Step 6: Add suspension solution to methanol to precipitate polymer and particles.

example 2

[0164] Solution Blending of PLLA / HAP Composite (100:1 wt / wt)

[0165] Step 1: Added 50 mg HAP particles into 300 mL of chloroform and stirred for 10-30 minutes to form bioceramic particle suspension solution.

[0166] Step 2: Slowly added 5 g PLLA into suspension solution and stirred about 8 hours to dissolve all polymer.

[0167] Step 3: Applied ultrasonic mixing to suspension solution for 15-30 min to further disperse HAP particles into PLLA solution.

[0168] Step 4: Added suspension solution to 1 L methanol to precipitate polymer and particles.

[0169] Step 5: Filtered the precipitate and dried about 24 hours in vacuum oven at 60° C. End product is PLLA / HAP composite.

[0170] Composites were also made with 2 wt % and 5 wt % HAP.

[0171] Mechanical Properties and Morphology of PLLA / HAP Composite (100:1 wt / wt)

[0172] Tensile testing of the composite samples and a pure PLLA were performed using an Instron tensile tester obtained from Instron in Canton, Mass. Test samples were prepared by hot p...

example 3

[0174] Solution Blending of PLLA / HAP Composite (2:1 wt / wt) as HAP Intermedium Mixture

[0175] Step 1: Added 25 g HAP particles to 3 L chloroform and stirred for 10-30 minutes to form bioceramic particle suspension solution.

[0176] Step 2: Slowly added 50 g PLLA into suspension solution and stirred about 8 hours to dissolve all polymer.

[0177] Step 3: Applied ultrasonic mixing for 15-30 min to further disperse HAP particles into PLLA solution.

[0178] Step 4: Added suspension solution to 9 L methanol to precipitate particles and polymer.

[0179] Step 5: Filtered the precipitate and dried about 24 hours in vacuum oven at 60° C. End product is PLLA / HAP composite.

[0180] Extrusion of Precipitated PLLA / HAP (2:1 wt / wt) with PLLA

[0181] Step 1: Broke 2:1 wt / wt composite into small pieces

[0182] Step 2: Mixed 24 g of broken up composite and 376 g PLLA.

[0183] Step 3: Extruded mixture at 216° C.

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Abstract

Methods and devices relating to polymer-bioceramic composite implantable medical devices are disclosed.

Description

CROSS-REFERENCE [0001] This application is a continuation-in-part of U.S. application Ser. No. 11 / 706,550 filed on Feb. 14, 2007, and a continuation-in-part of U.S. application Ser. No. 11 / 529,996 filed Sep. 29, 2006, and a continuation-in-part of U.S. application Ser. No. 11 / 523,866 filed on Sep. 19, 2006, which is a continuation-in-part of U.S. application Ser. No. 11 / 443,870 filed on May 30, 2006, which are all incorporated herein by reference.BACKGROUND OF THE INVENTION [0002] 1. Field of the Invention [0003] This invention relates to implantable medical devices and methods of fabricating implantable medical devices. [0004] 2. Description of the State of the Art [0005] This invention relates to radially expandable endoprostheses, which are adapted to be implanted in a bodily lumen. An “endoprosthesis” corresponds to an artificial device that is placed inside the body. A “lumen” refers to a cavity of a tubular organ such as a blood vessel. [0006] A stent is an example of such an ...

Claims

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Application Information

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IPC IPC(8): B29B9/08A61F2/00B29C48/05B29C48/08B29C48/09B29C48/32
CPCA61L31/127A61L31/128A61L31/148B29C47/0007Y10S977/831A61F2/82Y10S977/931Y10S977/753B29C47/0014B29C47/0021B29C47/0023Y10S977/776B29C48/05B29C48/08B29C48/09B29C48/023
Inventor WANG, YUNBINGGALE, DAVID C.
Owner ABBOTT CARDIOVASCULAR
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