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Method for preparation of bone hydroxyapatite-imitating bone repair material

A technology for imitating bone hydroxyapatite bone and hydroxyapatite is applied in the field of preparing bone imitating hydroxyapatite bone repair material and preparing nano-gradient porous structure hydroxyapatite bone repair material, and can solve the problem of degradation rate of bone repair material. Tissue crawling replacement rate mismatch, material biological activity and mechanical properties decreased, bone defect repair ability decreased, etc., to achieve the effect of excellent osteogenic activity, easy industrial production, and reduced brittleness

Inactive Publication Date: 2015-08-12
FIRST PEOPLES HOSPITAL OF YUNNAN PROVINCE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the hydroxyapatite bone repair materials prepared by the above methods all have the following problems: (1) Excessively high sintering temperature and long holding time will cause partial decomposition of hydroxyapatite (usually around 1000 ° C). Decomposition) and abnormal growth of particles, resulting in the reduction of material bioactivity and mechanical properties; at the same time, because the degradation rate of HA decomposition products (calcium phosphate and calcium pyrophosphate) is inconsistent with the degradation rate of HA, the degradation rate of the material and the crawling replacement rate of bone tissue (2) Although most of the binder added in the high temperature sintering process will decompose and volatilize, there is still a small amount of binder remaining in the material

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  • Method for preparation of bone hydroxyapatite-imitating bone repair material
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Examples

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Embodiment 1

[0024] A method for preparing a nanoscale bone-like gradient porous hydroxyapatite bone repair material by spark plasma sintering, specifically comprising the following steps:

[0025] 1) The hydroxyapatite ceramic powder with a purity of ≧97% and a particle size of 100nm and NH with a particle size of 100-500μm for analytical purity 4 HCO 3 The powders were mixed in the mixer for 120 minutes to obtain two mixed powders (mixed A powder and mixed B powder). Among them, the hydroxyapatite ceramic powder in the mixed A powder and the NH 4 HCO 3The mass percent of the powder is 85%:15%, and the hydroxyapatite ceramic powder and NH in the mixed B powder 4 HCO 3 The mass percentage of powder is 55%: 45%;

[0026] 2) Put the mixed powder obtained in step (1) into a stainless steel mold. Among them, the mixed A powder is put into the outer layer, and the mixed B powder is put into the inner layer. Under the unidirectional pressure of 100MPa, cold press molding is carried out, a...

Embodiment 2

[0031] A method for preparing a nanoscale bone-like gradient porous hydroxyapatite bone repair material by spark plasma sintering, specifically comprising the following steps:

[0032] 1) Combine hydroxyapatite ceramic powder with a purity of ≧97% and a particle size of 100nm and analytically pure NH 4 HCO 3 The powders were mixed in the mixer for 120 minutes according to the mass fraction percentage of 65%:35%, and the mixed powders were divided into two parts (mixed C powder and mixed D powder). Among them, the NH in the mixed C powder 4 HCO 3 The powder is sieved through a standard sieve with a particle size of 100-300 μm, and the NH in the mixed D powder 4 HCO 3 The powder is sieved through a standard sieve with a particle size of 300-500 μm;

[0033] 2) Put the mixed powder obtained in step (1) into a stainless steel mold. Among them, the mixed C powder is put into the outer layer, and the mixed D powder is put into the inner layer. Under the unidirectional pressur...

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Abstract

The invention discloses a method for preparation of a bone hydroxyapatite-imitating bone repair material, nano hydroxyapatite ceramic powder and NH4HCO3 powder are mixed proportionally, after mixing, the powder is loaded into a gradient mold for mechanical pressing into a block pressed blank, the block pressed blank is put into a discharge plasma sintering furnace, heated to 950 DEG C and 1050 DEG C in the heating rate of 100 DEG / min, and then kept warm for 10-20min, and after demoulding, a nano scale bone gradient-imitating porous hydroxyapatite bone repair material is obtained. The nano scale bone gradient-imitating porous hydroxyapatite bone repair material is prepared by the method comprises outer and inner two layers, the porosity is 34% to 80%, and the pore scale is controllable in the range of 100-500mum, and the nano scale bone gradient-imitating porous hydroxyapatite bone repair material has the advantages of fine grain size, composition purity, no residual pore former, controllable mechanical properties and degradation rate and the like, and can be used as a good artificial bone tissue repair material.

Description

technical field [0001] The invention belongs to the technical field of preparation of biomedical materials, and relates to a method for preparing a bone-like hydroxyapatite bone repair material, in particular to a method for preparing nano-sized hydroxyapatite bone repair materials by using discharge plasma sintering without adding binders and templates. Method for bone repair materials with graded gradient porous structure hydroxyapatite. Background technique [0002] Hydroxyapatite (Hydroxyapatite, HA), chemical formula: [Ca 5 (OH)(PO 4 ) 3 ], because the bioceramic material has the same crystal composition and structure as human bone, its biocompatibility, interface activity and osteoconductivity are superior to various medical alloys and other medical polymer materials, and it can directly form bonds with bone. It is considered to be the bone tissue repair material with the best bioactivity and biocompatibility. However, although high-density HA has high strength, du...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/12
Inventor 孟增东谢辉王成健
Owner FIRST PEOPLES HOSPITAL OF YUNNAN PROVINCE
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