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79 results about "Arg-Gly-Asp" patented technology
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Preparation method of bionic coating carrying bioactive factors
InactiveCN102327645AImprove long-term stabilityImprove stabilityImpression capsDentistry preparationsOsseointegrationArg-Gly-Asp
The invention provides a preparation method of bionic coating carrying bioactive factors, which is characterized in that: under a catalyzing system of carbodiimide and N-hydroxy-succinamide, Arg-Gly-Asp (RGD) polypeptide chain containing a disulfide bond is grafted onto polyelectrolyte and then is prepared into RGD grafted polyanion electrolyte solution and RGD grafted bioactive-factor-loaded polycation electrolyte solution, the polyanion electrolyte solution is combined with the polycation electrolyte solution carrying the bioactive factors to establish an organic composite coating carrying the bioactive factors on the surface of planting body through a static self-assembling technology. The composite coating solves the bottleneck problem of bioactive factors used surrounding the planting body, can promote the early growth of osteogenesis surrounding the planting body so as to realize the early osseointegration, and facilitates the long-term stability of the planting body. The method is simple to operate, has moderate preparation conditions, is convenient to control and can realize the continuous production.
Owner:ZHEJIANG UNIV
Preparation and uses of tumor-targeted carrier material RGD-fatty alcohol series of compounds
The invention discloses a method for preparing RGD-fatty alcohol series compounds as tumor targeting carrier materials and application thereof. The method comprises the following steps: conjugating n-octa alkyl fatty alcohol, decane-based fatty alcohol, dodecyl fatty alcohol, tetradecyl fatty alcohol, hexadecane fatty alcohol, and octadecyl fatty alcohol with RGD peptide segment respectively, and performing hydrophobic modification on the compounds to synthesize a peptide conjugated compound with different amphiphilic long-chain alkyls and RGD, namely Arg-Gly-Asp-O-CnH[2n +1] (n is equal to 8, 10, 12, 14, 16, or 18), and synthesize a compound of Gly-Gly-Asp-O-C4H29 simultaneously, thus the effectiveness of the targeting materials is further confirmed.
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Dexamethasone-RGD polypeptide conjugate, preparation method thereof and application
ActiveCN103044523AEnhanced inhibitory effectGood anti-inflammatory effectOrganic active ingredientsAntipyreticSide effectArg-Gly-Asp
The invention relates to a dexamethasone-RGD polypeptide conjugate shown as general formula i, a preparation method thereof and application. In the formula i, RGDX is tetrapeptide Arg-Gly-Asp-X, wherein X is any amino acid of Val, Phe and Ser. Proved by experiments, the compound of the present invention has excellent immunosuppressive effect and anti-inflammatory effect, and the side effects of osteoporosis is reduced. The conjugate can be used as an immunosuppressant and anti-inflammatory agent for the side effect of low osteoporosis clinically. At the same time, the dexamethasone-RGD polypeptide conjugate of the present invention can self-assemble into stable nanoparticles with particle size of 200-500 nm, therefore the conjugate can be prepared into a target drug of immunosuppressive pharmacosome, microemulsion or liposome.
Owner:SHANDONG HUBBLE KISEN BIOLOGICAL TECH CO LTD
Multifunctional fusion polypeptide and preparation method and application thereof
ActiveCN105713095AReduced hydroxyproline contentEasy to synthesizePolypeptide with localisation/targeting motifPeptide/protein ingredientsHydroxyprolineMedicine
The invention discloses a multifunctional fusion polypeptide and a preparation method and application thereof, and belongs to the field of biological pharmacy. The fusion polypeptide has the structural domains of Pro-(D-Pyr)-(D-Cys)-Bip-Arg-Gly-Glu, Ile-Val-Arg-Arg-Ala-Asp-Arg-Ala-Ala-Val-Pro, Arg-Gly-Asp and Gly-Gly-Gly-Gly; the fusion polypeptide can treat human lung fibrosis, pathological changes of lung tissue, lung cancers and other tumors, and in a lung fibrosis cell model, the fusion polypeptide can significantly reduce the hydroxyproline content in model group cells and inhibit the process of lung fibrosis. It is shown through MTT tests that the fusion polypeptide can inhibit proliferation of multiple kinds of anthropogenic tumor cells; the fusion polypeptide is prepared through an artificial synthesizing method, the preparation method is simple, and a good application prospect is achieved.
Owner:NANJING ANJI BIOLOGICAL TECH CO LTD
RGD modified 5-fluorouracil and preparation method, nanostructure, activity and application thereof
The invention discloses a compound being 5-fluorouracil-1-acetyl-Arg-Gly-Asp tetrapeptide, a preparation method, nanostructure, anti-tumor effect and tumor cell adhesion, invasion and migration resisting effect thereof, and application thereof in medical science.
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Amphipathic polypeptide molecule capable of being used as gene vector
ActiveCN106916209AEffective cohesionHigh-efficiency gene transfectionDepsipeptidesOther foreign material introduction processesHigh cellArg-Gly-Asp
The invention provides an amphipathic polypeptide molecule which can be used as a gene vector, and belongs to the field of gene engineering. The amphipathic polypeptide molecule can be combined with a gene molecule and introduces effective condensation thereof, and furthermore transfers the gene molecule into a cell so as to achieve high-effective gene transfection. A sequence of the amphipathic polypeptide molecule is represented as follows: Ac-Arg-Gly-Asp-Gly-Pro-Leu-Gly-Leu-Ala-Gly-Ile-Ile-Ile-Gly-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-NH2. The amphipathic polypeptide molecule can be combined with the gene molecule, so that the molecule has high cell combining capability and penetrability, and can be used as a gene vector and high-effectively applied to gene transfection.
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA)
Oxymatrine hepatic targeting nano drug delivery system and preparation method thereof
ActiveCN102961360AReduce intakeSpeed up entryOrganic active ingredientsDigestive systemPolyethylene glycolEvaporation
The invention relates to an oxymatrine hepatic targeting nano drug delivery system and a preparation method thereof. The oxymatrine hepatic targeting nano drug delivery system is prepared by the following steps of: with polyethylene glycol-polycaprolactone block polymer as a carrier, preparing polymer nanoparticles by adopting a film dispersion method, a reverse evaporation method or an organic solvent injection method, encapsulating oxymatrine into the polymer nanoparticles, then modifying a new glycoprotein or cyclic octapeptide ligand to be taken as a ligand on the surfaces of the nanoparticles, and constructing an anti-hepatic fibrosis nano targeting drug delivery system for hepatic stellate cells (HSCs). The nano drug delivery system has the advantages that particle size is 50-260nm, encapsulation efficiency is 18-42%, drug loading capacity is 2-12% and the surface of the nano drug delivery system is rich in new glycoprotein M6PHSA (mannose-6-phosphate human serum albumin) or cyclic octapeptide RGD (arg gly asp). The oxymatrine hepatic targeting nano drug delivery system provided by the invention can increase opportunities that nanoparticles enter the liver through blood circulation, is beneficial to targeting distribution of drugs at focus parts of the liver and is beneficial to absorption of drug-carrying nanoparticles at lesion parts of the liver and ingestion of HSCs, so that hepatic fibrosis treatment is enhanced.
Owner:NINGXIA MEDICAL UNIV
Fibroin-Like Protein Variant and Cell Culture Method
InactiveUS20190016763A1Effective trainingAntibody mimetics/scaffoldsNon-embryonic pluripotent stem cellsAdhesion processCulture cell
A technique for efficiently culturing cells such as stem cells is provided. Cells such as stem cells are cultured using a cell culture vessel coated with a fibroin-like protein into which a cell adhesion sequence containing RGD (Arg-Gly-Asp) is inserted.
Owner:AJINOMOTO CO INC
Integrin blocking agent polypeptide and applications of the same in preparation of drugs for treatment of neovascular eye diseases
ActiveCN104327169ASuppress generationInhibition formationSenses disorderPeptide/protein ingredientsIntegrin ligandArg-Gly-Asp
The present invention discloses an integrin blocking agent polypeptide and applications of the same in preparation of drugs for treatment of neovascular eye diseases, and belongs to the field of medicine. The integrin blocking agent polypeptide comprises a polypeptide I Arg-Gly-Asp-Gly-Gly-Gly-Gly-Phe- Gln-Pro-Val-Leu-His-Leu-Val-Ala-Leu-Asn-Ser-Pro-Leu-Ser-Gly-Gly-Met-Arg-Gly-Ile-Arg-Gly-Ala-Asp-Phe-Gln-Cys-Phe-Gln-Gln-Ala-Arg-Ala-Val-Gly-Leu-Ala-Gly-Thr-Phe-Arg-Ala and a polypeptide II Phe-Gln-Pro-Val-Leu-His-Leu-Val-Ala-Leu-Asn-Ser-Pro-Leu-Ser-Gly-Gly-Met-Arg-Gly-Ile-Arg-Gly-Ala-Asp-Phe-Gln-Cys-Phe-Gln-Gln-Ala-Arg-Al a-Val-Gly-Leu-Ala-Gly-Thr-Phe-Arg-Ala-Gly-Gly-Gly-Gly-Arg-Gly-Asp, wherein the polypeptide I is modified with the integrin ligand sequence (Arg-Gly-Asp-Gly-Gly-Gly-Gly). The integrin blocking agent polypeptide can be used for treatments of iridal neovascular eye diseases, choroidal neovascular eye diseases, retinal neovascular eye diseases or corneal neovascular eye diseases and other neovascular eye diseases.
Owner:NANJING ANJI BIOLOGICAL TECH CO LTD
Thrombin peptide derivatives
ActiveUS20050158301A1Long storage life in solutionNot easily oxidizedPeptide/protein ingredientsSkeletal disorderGlycineCysteine thiolate
Disclosed are thrombin peptide derivatives comprising a polypeptide having the amino acid sequence SEQ ID NO. 2: Arg-Gly-Asp-Ala-Xaa-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val, or a C-terminal truncated fragment of the polypeptide having at least six amino acids. Xaa is alanine, glycine, serine, or an S-protected cysteine. Zero, one, two, or three amino acids in the polypeptide or polypeptide fragment differ from the corresponding position of SEQ ID NO. 2. Also disclosed are methods of treating a subject in need of treatment with a thrombin receptor agonist. The methods comprise the step of administering an effective amount of the thrombin peptide derivative described above.
Owner:ORTHOLOGIC
Preparation method of bone repair hydrogel and fiber pipe composite material loading growth factors
InactiveCN102397586AGood adhesionPromote regenerationFilament/thread formingNon-woven fabricsFiberCell-Extracellular Matrix
The invention discloses a preparation method of a bone repair hydrogel and fiber pipe composite material loading growth factors. Firstly, a spinning solution is prepared, the spinning solution is arranged in a syringe, a nanometer fiber reticular layer is prepared by high-voltage electrospinning, sodium alginate modified by RGD (Arg-Gly-Asp) is irradiated with gamma rays, and after irradiation, the RGD-sodium alginate is filtered to be degermed and is stored at the room temperature of -20 DEG C so as to prepare hydrogel. According to the method disclosed by the invention, the sodium alginate degraded by gamma ray irradiation can be combined with adhesive peptide in covalence to promote cell attachment; a nanometer fiber pipe is prepared through electrostatic spinning, the fiber has a diameter being the same as that of an extracellular matrix (ECM) and a large specific surface area, can improve cell attachment and migration, and is suitable for osteoblast differentiation and stem cell in vitro regeneration; and the composite material consisting of the bone repair hydrogel and the fiber pipe can guide bone regeneration by hydrogel injected with the sodium alginate and the protein electrostatic spinning nanometer fiber reticular film, promotes the regeneration and repair functions of vessels, can be used as a bone repair transmission system, has a simple production process and is easy to operate.
Owner:WUXI ZHONGKE GUANGYUAN BIOMATERIALS
Integrin receptor target lipidosome drug carrier, preparation method and application thereof
The invention discloses an integrin receptor target lipidosome drug carrier and a preparation method thereof, as well as an application of the drug carrier in preparing antitumor lipidosome drug. Hexadecyl fatty chain is conjugated with RGD peptide segment and is hydrophobic-modified so as to synthesize hexadecyl and RGD peptide conjugate with amphipathy, namely, Arg-Gly-Asp-X-NH-C16H33, and X is selected from valine, serine or phenylalanine. The invention introduces fat-soluble antitumor drug into the conjugate with amphipathy to obtain the antitumor target lipidosome drug, the lipidosome system can increase the concentration of the antitumor drug at the target and can reduce toxic and side effects of the antitumor drug to the non-target part, thereby improving the treatment index of the drug. The invention evaluates the antitumor activity of taxol lipidosome by using a Holland sarcoma S180 mouse as a model, the result shows that the taxol lipidosome has more excellent antitumor activity than each control group.
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Hydrocortisone-RGD polypeptide conjugate, and preparation method and application thereof
ActiveCN103012554AEnhanced inhibitory effectGood anti-inflammatory effectAntipyreticAnalgesicsSide effectArg-Gly-Asp
The invention relates to a hydrocortisone-RGD polypeptide conjugate shown in a general formula i, and a preparation method and application thereof. In the general formula i, RGDX is tetrapeptide Arg-Gly-Asp-X, and X is any one of three amino acids of Val, Phe and Ser. Experiments prove that the compound provided by the invention has excellent immunological suppression effect and anti-inflammatory effect and the side effect of osteoporosis is reduced. The compound can be clinically used as an immunological suppressant and anti-inflammatory agent having low side effect of osteoporosis. Meanwhile, the hydrocortisone-RGD polypeptide conjugate can form nano spheres having a stable particle diameter of 200-700 nm through self assembly in a water solution. Thus, the hydrocortisone-RGD polypeptide conjugate can be prepared into an immunological suppression pharmacosome, microemulsion or liposome targeted medicament.
Owner:SHANDONG HUBBLE KISEN BIOLOGICAL TECH CO LTD
Arg-gly-asp-conjugated alpha-melanocyte stimulating hormone hybrid peptide for use in diagnosing and treating melanoma, including metastatic melanoma and methods related to same
ActiveUS20120107237A1Decrease renal uptakeImprove pharmacokineticsRadioactive preparation carriersDepsipeptidesCyclic peptideTissue biopsy
The present invention is directed to novel non-invasive diagnostic and therapeutic tools / compounds comprising a hybride cyclic peptide which utilizes a cyclic peptide chelating group wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma / metastatic melanoma. Compound according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.
Owner:STC UNM
Preparation method of fatty acyl-RGD (Arg Gly Asp) induced docetaxel target liposome and antitumor activity thereof
InactiveCN102250205AOrganic active ingredientsPeptide preparation methodsCarbon numberLong chain fatty acid
The invention discloses a preparation method of a fatty acyl-RGD (Arg Gly Asp) induced docetaxel target liposome and antitumor activity thereof. Alkyl fatty acids with different carbon numbers are conjugated with the amino ends of RGD peptides, and hydrophobic modification is performed to synthesize amphiphilic conjugates of different alkyl fatty acid chains and RGD peptides, namely CnH2n+1CO-Arg-Gly-Asp, wherein n represents the carbon number of different long-chain fatty acids and is 7, 9,11,13 or 15. In addition, the invention also contains liposome preparations containing the conjugates and docetaxel, and the preparations are used to resist tumor.
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Thrombin peptide derivatives
ActiveUS7713934B2Prolong lifeNot easily oxidizedPeptide/protein ingredientsSkeletal disorderGlycineGly-Gly-Pro
Owner:ORTHOLOGIC
Peptide for Use in the Treatment of Breast Cancer and/or Bone Metastases
ActiveUS20130115210A1Increase volumeIncrease the number ofHeavy metal active ingredientsOrganic active ingredientsArg-Gly-AspRadiation therapy
The invention relates to the use of the Peptide of the formula Cyclo-(Arg-Gly-Asp-DPhe-NMe-Val) and / or the pharmaceutically acceptable dervatives, solvates and / or salts thereof, for the manufacture of a medicament for the treatment of breast cancer and / or bone metastases in humans, wherein the medicament is optionally to be used in combination with one or more cancer cotherapeutic agents, preferably selected from a) hormone modulating agents, b) osteoclast activity modulating agents, c) cancer chemotherapeutic agents, and / or d) radiotherapy, alone, concurrently or not in the dosage regime of the present invention.
Owner:MERCK PATENT GMBH
Method of treating tumors
InactiveUS7029652B2Improve anti-tumor effectPromote apoptosisSenses disorderSkeletal disorderChemical LinkageTumor target
A method of treating tumors, such as prostate tumors, breast tumors, non-Hodgkin's lymphoma, and the like, includes the sequential steps of administering to the patient at least one dose of an antiangiogenic cyclo-arginine-glycine-aspartic acid-containing pentapeptide (cRGD pentapeptide); administering to the patient an anti-tumor effective amount of a radioimmunotherapeutic agent (RIT); and then administering to the patient at least one additional dose of cRGD pentapeptide. The cRGD pentapeptide is preferably cyclo-(Arg-Gly-Asp-D-Phe-[N-Me]-Val), and the RIT is preferably a radionuclide-labeled chelating agent-ligand complex in which chelating agent is chemically bonded to a tumor-targeting molecule, such as a monoclonal antibody.
Owner:MERCK PATENT GMBH +1
Preparation method of RGD (Arg-Gly-Asp) and PEG (Polyethylene Glycol) co-modified PAMAM (Polyamide-Amne Dendrimer) arsenic trioxide-loaded medicine delivery system
ActiveCN106667963AIncreased in vitro safetyImproved pharmacokinetic profileInorganic active ingredientsPharmaceutical non-active ingredientsDendrimerPolyamide
The invention discloses a preparation method of an RGD (Arg-Gly-Asp) and PEG (Polyethylene Glycol) co-modified PAMAM (Polyamide-Amne Dendrimer) arsenic trioxide-loaded medicine delivery system. The preparation method comprises the following steps: enabling a sulfydryl group of an RGD cyclopeptide to react with a maleimide group of MAL-PEG-NHS, thus generating RGD-PEG-NHS; then reacting with a surface amino group of PAMAM, thus generating RGD-PEG-PAMAM; enabling the RGD-PEG-PAMAM to react with mPEG-NHS, thus preparing RGD-PEG-PAMAM-mPEG; enabling an arsenic trioxide solution to react with the RGD-PEG-PAMAM-mPEG, thus preparing the RGD and PEG co-modified PAMAM arsenic trioxide-loaded medicine delivery system. According to the preparation method disclosed by the invention, highly toxic traditional Chinese medicine-arsenic trioxide is firstly loaded in PAMAM; compared with an original medicine, a certain slow release action can be reflected, and the problems that ATO is poor in fat solubility, the blood-brain barrier penetration is difficult, body distribution is lack of specificity, and the like are solved; RGD is used for modifying the PAMAM, so that cellular uptake of tumor cells on the PAMAM is further increased; mPEG is used for modifying residual amino groups on the PAMAM, so that the cytotoxicity of a carrier can be further reduced.
Owner:ZHEJIANG CHINESE MEDICAL UNIVERSITY
Modified Polyaryletherketone Polymer (Paek) and Process To Obtain It
InactiveUS20160053042A1Enhanced osteoblast adhesionImproved osteoinduction propertyPharmaceutical delivery mechanismTissue regenerationThio-Pyrenesulfonyl azide
The present invention relates to a modified polyaryletherketone polymer (PAEK) with chemically modified surfaces with azides, alkynes, thiols, maleimides, sulfonylazides or thio acids, suitable for “click” reactions and to a process to obtain it. It also relates to the conjugated biomaterials derived thereof, PAEK type materials with surfaces modified with a RGD (Arg-Gly-Asp) and / or OGP10-14 (Tyr-Gly-Phe-Gly-Gly) peptidomimetics and to a process to obtain it. These materials are particularly useful for manufacturing medical devices. Finally, the present invention also relates to a fluorescent PAEK material.
Owner:UNIV DEL PAIS VASCO +2
Peroxide nanoenzyme and preparation method thereof
ActiveCN106011125ALow GPx activityIncrease vitalityOxidoreductasesOn/in inorganic carrierSide chainPeroxidase
The invention provides a peroxide nanoenzyme and a preparation method thereof, belonging to the technical field of nano-biotechnology. According to the method, a gold nanoparticle is used as a carrier, biologically active pentapeptide (URGDC) is employed for self-assembly, and a mercapto group in a pentapeptide and the gold nanoparticle undergo coordination and covalent coupling so as to obtain the peroxide nanoenzyme with high GPx activity. The method is simple to operate and has good stability. The amino acid sequence of the biologically active pentapeptide is Sec-Arg-Gly-Asp-Cys (referred as URGDC for short), wherein Sec(U) contains the active center of the nanoenzyme, Arg-Gly-Asp (RGD) can promote bonding between the nanoenzyme and a substrate, and the mercapto group in a Cys (C) side chain can realize covalent connection with the gold nanoparticle. The gold nanoparticle is used as a carrier for immobilizing the biologically active pentapeptide, promotes full contact between the nanoenzyme and the substrate, and improves activity of glutathion peroxidase.
Owner:JILIN UNIV
Application of blood vessel inhibiting polypeptides with integrin affinity and bonding capability and MMPs (matrix metalloproteinases) inhibiting capability
ActiveCN104840941AII works wellInhibition formationSenses disorderPeptide/protein ingredientsDiseaseArginine
The invention discloses an application of a blocker with integrin affinity and bonding capability and MMPs (matrix metalloproteinases) inhibiting capability, and belongs to the field of medicines. The application comprises a polypeptide I (Arg-Gly-Asp-Gly-Gly-Gly-Gly-Pro-(D-Pyr)-(D-Cys)-Bip-Arg-Gly-Glu) and a polypeptide II (Pro-(D-Pyr)-(D-Cys)-Bip-Arg-Gly-Glu-Gly-Gly-Gly-Gly-Arg-Gly-Asp), wherein the polypeptide I is modified with an integrin ligand sequence (Arg-Gly-Asp-Gly-Gly-Gly-Gly); two types of blood vessel inhibiting polypeptides with integrin affinity and bonding capability are formed. The application has the advantages that because of the targeting property of an RGD (arginine-glycin-aspartate) sequence, the polypeptides can be targeted to the new blood vessel endothelium of the RA (rheumatoid arthritis) pannus forming process, the forming of MMPs (matrix metalloproteinases) and the new blood vessel can be inhibited, and the effect of preventing or treating the blood vessel and inflammatory diseases are realized; the polypeptides can be applied to the treatment of the blood vessel and inflammatory diseases, such as arthritis, inflammation, tumors, and eye diseases.
Owner:NANJING ANJI BIOLOGICAL TECH CO LTD
Radioactive rhenium marked polypeptide containing RGD sequence as well as preparation method and application thereof
InactiveCN101423546ADid not change the structureDoes not affect biological activityIn-vivo radioactive preparationsEchographic/ultrasound-imaging preparationsRheniumAngiogenesis growth factor
The invention discloses a polypeptide which is marked by radioactive rhenium and contains RGD amino acid sequence, a preparation method and application thereof, wherein N terminal of the polypeptide is histidine residue which is chelated with radioactive rhenium. The structure of the polypeptide is shown as general formula (I), wherein X is a polypeptide chain containing Arg-Gly-Asp sequence. The polypeptide adopts raw materials available. The whole experiment process has simple operation, does not have special requirements such as high temperature and high pressure, adopts a [Re(CO)3(H2O)3]<+> precursor to mark the polypeptide, does not change the structure of the polypeptide, does not affect the biological activity of the polypeptide, and has important realistic significance on early diagnosis and treatment of angiogenesis and tumor transfer.
Owner:SHANGHAI INST OF APPLIED PHYSICS - CHINESE ACAD OF SCI
Active molecule capable of suppressing gene replication of Ebola virus and usage method thereof
InactiveCN105063044AGood curative effectCompounds screening/testingPowder deliveryLipid formationRed blood cell
Owner:SIRNAOMICS BIOPHARMACEUTICALS (SUZHOU) CO LTD
Anti-tumor peptide molecule with multiplex targeting performance and selectivity and application thereof
ActiveCN107226847AGuaranteed free conformationGuaranteed functionPeptide/protein ingredientsDepsipeptidesNon toxicityNormal cell
The invention provides an anti-tumor peptide molecule with multiplex targeting performance and selectivity and application thereof, and belongs to the field of targeted medicine molecules. The molecule structure completeness and the cell non-toxicity can be maintained in the normal cell positions; cell antipersonnel fragments can be released in the tumor cell positions, so that the selective killing on the tumor cells can be realized; meanwhile, the duplex targeting performance can be realized on the tumor cells. The peptide molecule has the following sequence of Ac-Arg-Gly-Asp-Gly-Pro-Leu-Gly-Leu-Ala-Gly-Ile-Ile-Ile-Gly-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-NH2(RR22), and can be subjected to enzymolysis by substrate metalloprotease to release LR15 fragments Leu-Ala-Gly-Ile-Ile-Ile-Gly-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-NH2 with the tumor cell killing performance. The anti-tumor peptide molecule provided by the invention can be used for preparing tumor cell selective killing agents, and can be effectively applied to targeted killing of tumor cells. Compared with other targeting medicine, the anti-tumor peptide molecule has wider application values.
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA)
Peptides modulating caspase activation
InactiveCN1703428APeptide/protein ingredientsImmunoglobulins against animals/humansAutoimmune diseaseImmunodeficiency
The present invention provides structures of small molecules capable of modulating apoptotic cell death. More specifically, the structures relate to the structures of apoptotic active sites of mammalian alpha-fetoprotein (AFP) and albumin. Peptides mimicking the active site contain two sequences, Arg-Gly-Asp and Asp-X-X-Asp, wherein X means any amino acid. These sequences are needed in the same molecule for causing a wide range of biological activities. The peptides can be utilized to suppress apoptotic pathways by inhibiting the cytochrome c-mediated caspaseactivation. Thus, the peptides can be used to inhibit effects of apoptosis induced by oxidative stress, drugs, cytokines, Fas-ligand, alpha-fetoprotein, used to prevent apoptosis in culturing cells, in organ transplantation, in immunological autoimmune disorders and immunodeficiency syndrom induced by viral infection, or to diminish side cytotoxic effects after chemotherapy and radiation therapy.
Owner:鲍里斯·爱德华多维奇·塔图洛夫
Antithrombotic medicine RWR for specifically identifying platelet alpha<IIb>beta3
InactiveCN102351948AHigh biological activityLittle side effectsPeptide/protein ingredientsPeptide preparation methodsSmall peptideArg-Gly-Asp
The invention provides a small molecular polypeptide for reforming RGD tripeptide. According to the characteristic that the RGD is specifically combined with alpha<IIb>beta3, a hydrophobic amino acid and a basic amino acid are added at the N end of the RGD, a hydrophobic amino acid W is added in the fourth site, a basic amino acid R is added in the fifth site, the small peptide sequence is Arg-Gly-Asp-Trp-Arg, the protein primary structure is RGDWR, the capability for specifically being combined with the alpha<IIb>beta3 can be improved, the immunogenicity can also be reduced by smaller molecular weight, and the defects of the existing antithrombotic preparations are overcome.
Owner:SHANXI MEDICAL UNIV
Arg-Gly-Asp (RGD) Sequence Containing Cyclic Peptide and Its Active Targeting Liposomes
InactiveUS20100098748A1Good treatment effectImprove liver functionDigestive systemImmunoglobulinsCyclic peptideHepatic fibrosis
The present invention relates to the field of pharmaceutics and clinical pharmacy, involving the preparation method and application of a cyclic peptide containing Argnine-Glycine-Aspartate sequence and its active targeting liposomes. The cyclic peptide described here meets the requirement for ligand in that it forms ring by amide linkage with stable sterical structure, it shows low propensity to degrade, and it carries an active hydrosulfide group which is easy to modify carriers. The artificially synthesized peptide, which has a small molecular weight and low propensity to cause immune response, can be used as the ligand to bind with the integrin on the surface of HSC. The active targeting liposome established with the cyclic peptide realized cell-targeted therapy of experimental hepatic fibrosis via receptor-mediated pathway. The invention can target RGD cyclic peptide-labeled interferon-loaded liposomes to the fibrotic liver and its good efficacy in the treatment of hepatic fibrosis has been proven by experiments in rats in vitro and in vivo.
Owner:ZHONGSHAN HOSPITAL FUDAN UNIV +1
Three-dimensional nano stent of gene delivery system, preparation method and application thereof
The invention discloses a three-dimensional nano stent of a gene delivery system, consisting of collagen, chitosan and fiber binding protein. The three-dimensional nano stent of the gene delivery system is characterized by comprising calcium phosphate compound nano particles carried with gene, and being loosened and poriferous. The mass ratio of collagen, chitosan, fiber binding protein and glutaraldehyde is 1:1:0.005:0.0124-1:100:0.08:0.24; the fiber binding protein comprises aspartate (Arg-Gly-Asp, RGD) sequence, the calcium phosphate compound nano particles carried with plasmid are calciumphosphate nano particles which are spherical, carry therapy gene, and have the diameter smaller than 50nm, the content of the calcium phosphate compound nano particles is 0.01%-1% of the total mass of the three-dimensional nano stent. In the three-dimensional nano stent of the gene delivery system of the invention, within 3-15 days, the protein expression level is maintained about 10ng / ml, which shows that the three-dimensional nano stent embedded with the calcium phosphate compound nano particles carried with gene has characteristics of obvious controlled release and slow release.
Owner:JIANGSU UNIV
Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptide for use in diagnosing and treating melanoma, including metastatic melanoma and methods related to same
The present invention is directed to novel non-invasive diagnostic and therapeutic tools / compounds comprising a hybride cyclic peptide which utilizes a cyclic peptide chelating group wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma / metastatic melanoma. Compound according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.
Owner:STC UNM
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