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Traditional Chinese medicine composition with scalp inflammation-relieving and itching-relieving effects and preparation method thereof

A composition and technology of traditional Chinese medicine, applied to the antipruritic traditional Chinese medicine composition and its preparation, has the field of relieving scalp inflammation, and can solve the problems that the treatment effect cannot meet our needs, the stability of the components is poor, and the preparation process is complicated, etc., to achieve Satisfy the effects of scalp anti-inflammatory and anti-itching, good stability, and reasonable process design

Inactive Publication Date: 2020-11-24
SHANGHAI JAKA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most ointments for treating scalp inflammation in the market now contain traditional Chinese medicine components, which make them have excellent anti-inflammatory and antipruritic effects. However, the preparation process of existing ointments is relatively complicated, and the stability of the components is poor, so the therapeutic effect cannot meet our needs. need

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] S1: Prepare materials;

[0045] S2: Take pine needles and coriander, wash and drain, shear and crush, mix and stir for 3 minutes, pass through a 20-mesh sieve to obtain a mixture, put the mixture in ether, mix and stir for 20 minutes, and perform supercritical CO 2 Extraction, the extraction time is 4min, the extraction temperature is 45°C, and the extraction pressure is 25MPa to obtain the first essential oil;

[0046] S3: Take agarwood, crush it through a 40-mesh sieve, soak it in distilled water for 60 hours, take it out and filter it, air-dry it, place it in ethyl acetate, mix and stir it for 4 minutes, and perform supercritical CO 2 Extraction, the extraction time is 1h, the extraction temperature is 45°C, and the extraction pressure is 18MPa to obtain the second essential oil;

[0047] S4: Take Centella asiatica, cut and crush it, pass through a 20-mesh sieve, put it in a 65% ethanol solution, and extract it with ethanol for 50 minutes at an ultrasonic power of 3...

Embodiment 2

[0053] S1: Prepare materials;

[0054] S2: Take pine needles and coriander, wash and drain, shear and crush, mix and stir for 4 minutes, pass through a 20-mesh sieve to obtain a mixture, put the mixture in ether, mix and stir for 22 minutes, and perform supercritical CO 2 Extraction, the extraction time is 5min, the extraction temperature is 46°C, and the extraction pressure is 27MPa to obtain the first essential oil;

[0055] S3: Take agarwood, crush it through a 40-mesh sieve, soak it in distilled water for 64 hours, take it out and filter it, air-dry it, put it in ethyl acetate, mix and stir for 5 minutes, and perform supercritical CO 2 Extraction, the extraction time is 1.2h, the extraction temperature is 47°C, and the extraction pressure is 20MPa to obtain the second essential oil;

[0056] S4: Take Centella asiatica, cut and crush it, pass through a 20-mesh sieve, put it in a 65% ethanol solution, and extract it with ethanol for 52 minutes at an ultrasonic power of 355W...

Embodiment 3

[0062] S1: Prepare materials;

[0063] S2: Take pine needles and coriander, wash and drain, shear and crush, mix and stir for 5 minutes, pass through a 20-mesh sieve to obtain a mixture, put the mixture in ether, mix and stir for 28 minutes, and perform supercritical CO 2 Extraction, the extraction time is 5min, the extraction temperature is 47°C, and the extraction pressure is 27MPa to obtain the first essential oil;

[0064] S3: Take agarwood, crush it through a 40-mesh sieve, soak it in distilled water for 68 hours, take it out and filter it, air-dry it, put it in ethyl acetate, mix and stir it for 5 minutes, and perform supercritical CO 2 Extraction, the extraction time is 1.8h, the extraction temperature is 48°C, and the extraction pressure is 18-30MPa to obtain the second essential oil;

[0065] S4: Take Centella asiatica, cut and crush it, pass through a 20-mesh sieve, put it in a 65% ethanol solution, and extract it with ethanol for 58 minutes at an ultrasonic power o...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition with the scalp inflammation-relieving and itching-relieving effects and a preparation method thereof. The traditional Chinese medicine composition comprises the components including first essential oil, second essential oil, a herba centellae extracting solution, chitosan, glucolactone and the like; the first essential oil is essential oil prepared from pine needles and coriander through supercritical CO2 extraction; and the agilawood essential oil (the second essential oil) is obtained through extraction with the supercriticalCO2 extraction technology, ethyl acetate is adopted as an entrainer during extraction, and meanwhile, agilawood is pretreated after being smashed before extraction, so that the extraction rate of theagilawood essential oil can be effectively increased. According to the traditional Chinese medicine composition with the scalp inflammation-relieving and itching-relieving effects and the preparationmethod thereof, the process design is reasonable, the operation is simple, the prepared traditional Chinese medicine composition not only has excellent inflammation diminishing, itching relieving, antibacterial and bacteriostatic effects, but also can be used for scalp inflammation treatment, the traditional Chinese medicine composition is relatively good in component stability, and a medicine has a long-acting slow-release effect. In actual use, the effect is better, and the practicability is relatively high.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition capable of relieving scalp inflammation and relieving itching and a preparation method thereof. Background technique [0002] The head is where there are many sebaceous glands. It is a normal physiological function for the skin sebaceous glands to secrete sebum. However, if the sebaceous glands secrete excessively and the sebum is excreted too much, it will accumulate on the skin, and chronic skin inflammation will appear at the accumulation place. Scalp seborrheic dermatitis refers to a mild flushing patch that occurs on the scalp, covered with off-white bran-like scales, accompanied by mild itching, the rash expands, and greasy scaly map-like patches can be seen. [0003] Most ointments for treating scalp inflammation in the market now contain traditional Chinese medicine components, which make them have excellent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61K47/36A61K47/18A61K47/34A61K47/24A61K47/28A61K47/22A61P17/08A61P29/00A61P17/04A61P31/04A61P31/10A61K31/722A61K31/366
CPCA61K31/366A61K31/722A61K36/15A61K36/23A61K36/515A61K36/704A61K36/835A61K36/85A61K47/183A61K47/22A61K47/24A61K47/28A61K47/34A61K47/36A61K2236/331A61K2236/37A61K2236/39A61K2236/51A61P17/04A61P17/08A61P29/00A61P31/04A61P31/10A61K2300/00
Inventor 田军卢伊娜
Owner SHANGHAI JAKA BIOTECH CO LTD
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