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Golf ball-shaped degradable microspheres with microtopological structure and preparation method thereof

A topology and golf ball technology, applied in the field of golf ball degradable microspheres and its preparation, can solve the problems of catalysts and toxic chemical residues, promote cell adhesion and growth, stimulate the expression and preparation of metabolites The effect of simple process

Active Publication Date: 2021-12-21
SHANGHAI MOYANG BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, most of the microspheres prepared based on the above materials are smooth, and there are few researches and product reports on the surface microtopology of the microspheres. Realized, with risk of catalyst and toxic chemical residues

Method used

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  • Golf ball-shaped degradable microspheres with microtopological structure and preparation method thereof
  • Golf ball-shaped degradable microspheres with microtopological structure and preparation method thereof
  • Golf ball-shaped degradable microspheres with microtopological structure and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1. To investigate the influence of the proportion of PCL in component B on the preparation of golf microspheres.

[0029] Step 1: Add a total of 1 g of component A polylactic acid (molecular weight: 100KD) and component B polycaprolactone (molecular weight: 40KD) according to 99:1, 90:10, 80:20, 70:30, 60:40, The mass ratio of 50:50 is dissolved in 20ml of dichloromethane component C together to form the material concentration of 5% biological mixture solution component D;

[0030] Step 2: Add component D to 200ml of 0.1% PVA stabilizer solution component E, and form emulsion component F by stirring and mixing;

[0031] Step 3: Continue stirring and mixing until the organic solution in component F is completely volatilized to form component G.

[0032] Step 4: Wash component G with water or buffer solution as required, remove residual stabilizer solution component E, and obtain golf microspheres.

[0033] Step 5: The golf microspheres are sterilized and freeze...

Embodiment 2

[0036] Example 2, investigating the influence of the molecular weight ratio of materials on the preparation of golf microspheres.

[0037] Step 1: Dissolve 1 g of component A polylactic acid (molecular weight 100KD, 150KD, 200KD) and component B polycaprolactone (molecular weight 20KD, 40KD, 60KD and 100KD) in a mass ratio of 50:50 in In 20ml of dichloromethane component C, the concentration of the forming material is 5% biological mixture solution component D;

[0038] Step 2: Add component D to 200ml of 0.1% PVA stabilizer solution component E, and form emulsion component F by stirring and mixing;

[0039] Step 3: Continue stirring and mixing until the organic solution in component F is completely volatilized to form component G.

[0040] Step 4: Wash component G with water or buffer solution as required to remove the residual to obtain golf-shaped microspheres.

[0041] Step 5: The golf microspheres are sterilized and freeze-dried in an aseptic environment to obtain steri...

Embodiment 3

[0044] Example 3. Investigate the influence of the type and proportion of component A on the preparation of golf-type microspheres.

[0045]Step 1: Dissolve 1 g of different component A (including PLA, PLGA and a mixture of the above two materials in different proportions) and component B polycaprolactone (molecular weight 40KD) in a mass ratio of 50:50 in In 20ml of dichloromethane component C, the concentration of the forming material is 5% biological mixture solution component D;

[0046] Step 2: Add component D to 200ml of 0.1% PVA stabilizer solution component E, and form emulsion component F by stirring and mixing;

[0047] Step 3: Continue stirring and mixing until the organic solution in component F is completely volatilized to form component G.

[0048] Step 4: Wash component G with water or buffer solution as required to remove the residual to obtain golf-shaped microspheres.

[0049] Step 5: The golf microspheres are sterilized and freeze-dried in an aseptic envir...

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Abstract

The invention proposes a golf ball-shaped degradable microsphere with a microtopological structure and a preparation method thereof. The microsphere is composed of PCL and other polymer material components, the diameter of the microsphere is 1 μm to 600 μm, and the appearance is sunken or wrinkled inward. Spherical structure with microtopology. Simply arrange component A and component B according to the mass ratio of 99:1 to 50:50, and dissolve in organic solvent component C to form mixed solution component D, and then add stabilizer solution component E Component F is formed by stirring and mixing, and the stirring and mixing is continued until the organic solution in component F is completely volatilized to form component G. Wash component G with water or buffer solution as required to remove residual golf balls. The invention avoids the residue of chemical by-products and catalysts, the preparation process is simpler and the cost is lower, and the microtopological structure on the surface can promote cell adhesion and growth, which is beneficial to the fields of antibody production, three-dimensional cell culture, tissue repair, etc. promote.

Description

technical field [0001] The invention relates to the field of polymer materials, in particular to a golf ball-shaped degradable microsphere with a microtopological structure and a preparation method thereof. Background technique [0002] The degradable microsphere refers to a spherical or ellipsoidal polymer carrier form with a particle size of 1-600 μm, which is prepared from degradable polymer biomaterials and has degradable properties. Due to their small size, large specific surface area, and degradable characteristics, degradable microspheres are often used as carriers for drugs and cells, and tools for carrying, transporting, and releasing biologically active substances. They are used in medical tissue engineering, regeneration It has a wide range of applications in medicine, medical cosmetology, agriculture and environmental protection. [0003] Biopolyester materials are a class of biodegradable polymer materials with ester bonds as the main chemical bonds. They have ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/02C08L67/04
CPCB01J13/02C08L67/04C08L2201/06A61K9/1647C08J2367/04C08J2467/04C08J3/16
Inventor 不公告发明人
Owner SHANGHAI MOYANG BIOTECHNOLOGY CO LTD
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