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A kind of glycyrrhetinic acid liposome and preparation method thereof

A technology of glycyrrhetinic acid and acid lipids, which can be used in pharmaceutical formulations, toiletry preparations, cosmetic preparations, etc., can solve problems such as skin damage and organic substance residues, and achieve stable system, simple preparation process, safe and non-toxic particles diameter effect

Active Publication Date: 2018-10-12
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the above-mentioned technical problems in the prior art, the invention provides a kind of glycyrrhetinic acid liposome and preparation method thereof, described this glycyrrhetinic acid liposome and preparation method thereof have solved the problem of licorice in the prior art Due to the extensive use of toxic organic reagents in the preparation method of hypoxic acid liposomes, it is easy to cause organic substance residues and cause technical problems to the skin

Method used

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  • A kind of glycyrrhetinic acid liposome and preparation method thereof
  • A kind of glycyrrhetinic acid liposome and preparation method thereof
  • A kind of glycyrrhetinic acid liposome and preparation method thereof

Examples

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Effect test

Embodiment 1

[0056] A liposome coated with glycyrrhetinic acid, calculated by weight percentage, the composition and content of each raw material are as follows:

[0057]

[0058] The lecithin is soybean lecithin with a PC content of 25%, an industrial-grade product produced by Beijing Meiyasi Phospholipid Technology Co., Ltd.;

[0059] The glycyrrhetinic acid is a standard product with a purity of 98%, Shanghai Ronghe Pharmaceutical Technology Development Co., Ltd.;

[0060] Described water-soluble grease is PEG-6 octanoic acid caprate, Fu Platinum Chemical Co., Ltd.;

[0061] The polyol is 1,2-propanediol, an analytical-grade product produced by Sinopharm Chemical Reagent Co., Ltd.;

[0062] The surfactant is polyoxyethylene sorbitan laurate, a chemical grade product produced by Sinopharm Chemical Reagent Co., Ltd.;

[0063] The inorganic salt is magnesium sulfate, an analytical-grade product produced by Sinopharm Chemical Reagent Co., Ltd.

[0064] The preparation method of above-...

Embodiment 2

[0073] A liposome coated with glycyrrhetinic acid, calculated by weight percentage, the composition and content of each raw material are as follows:

[0074]

[0075] The lecithin is soybean lecithin with a PC content of 50%, an industrial-grade product produced by Beijing Meiyasi Phospholipid Technology Co., Ltd.;

[0076] The glycyrrhetinic acid is a standard product with a purity of 99%, Shanghai Ronghe Pharmaceutical Technology Development Co., Ltd.;

[0077] Described water-soluble oil is PEG-30 glycerol cocoate, Fu Platinum Chemical Co., Ltd.;

[0078] The polyol is 1,3-butanediol, an analytical-grade product produced by Sinopharm Chemical Reagent Co., Ltd.;

[0079] The surfactant is polyoxyethylene sorbitan stearate, a chemical grade product produced by Sinopharm Chemical Reagent Co., Ltd.;

[0080] The inorganic salt is sodium chloride, an analytical-grade product produced by Sinopharm Chemical Reagent Co., Ltd.

[0081] The preparation method of above-mentioned...

Embodiment 3

[0089] A liposome coated with glycyrrhetinic acid, calculated by weight percentage, the composition and content of each raw material are as follows:

[0090]

[0091] The lecithin is an egg yolk lecithin with a PC content of 70%, an industrial-grade product produced by Beijing Meas Phospholipid Technology Co., Ltd.;

[0092] The glycyrrhetinic acid is a standard product with a purity of 100%, Shanghai Ronghe Pharmaceutical Technology Development Co., Ltd.;

[0093] Described water-soluble oil is PEG-80 glycerol cocoate, Fu Platinum Chemical Co., Ltd.;

[0094] The polyhydric alcohol is glycerol, an analytical-grade product produced by Sinopharm Chemical Reagent Co., Ltd.;

[0095] The surfactant is polyoxyethylene sorbitan monooleate, a chemical-grade product produced by Sinopharm Chemical Reagent Co., Ltd.;

[0096] The inorganic salt is sodium citrate, an analytical-grade product produced by Sinopharm Chemical Reagent Co., Ltd.

[0097] The preparation method of above-...

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Abstract

The invention relates to glycyrrhetinic acid liposome, comprising, by weight, 1-20% of lecithin, 0.01-0.5% of glycyrrhetinic acid, 1-10% of water-soluble grease, 1-15% of polyols, 0.1-2% of a surfactant, 0.01-0.2% of an inorganic salt, and the balance of water. The invention also provides a preparation method of the glycyrrhetinic acid liposome. The method includes: dissolving the lecithin and the glycyrrhetinic acid in a mixture of the polyols and the water-soluble grease to obtain an organic phase; evenly dispersing the surfactant and the inorganic salt, and dissolving them in water to obtain an aqueous phase; slowly adding the organic phase at constant speed into the aqueous phase to obtain glycyrrhetinic acid liposome suspension; stirring the glycyrrhetinic acid liposome suspension under ultrasonic to obtain a uniform system, and allowing the system to naturally cool to the room temperature to obtain the glycyrrhetinic acid liposome. The glycyrrhetinic acid liposome obtained by using the method has the stable system, long and slow-release action and mild to skin.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and relates to a glycyrrhetinic acid liposome and a preparation method thereof. Background technique [0002] Liposomes are hollow vesicles formed by phospholipids dispersed in water. They are widely used in cosmetics because of their unique phospholipid bilayers, which have a structure similar to cell membranes and have affinity with the skin. Liposomes provide remarkable properties for cosmetic formulations. They make the skin smooth, soft, elastic, and occlusive, and can create a thin film on the skin to prevent water loss from the skin. In addition, as a coating carrier, liposome can coat fat-soluble and water-soluble active ingredients in its phospholipid bilayer and hollow core, and act on the deep layer of the skin to play a slow-release effect. [0003] Glycyrrhetinic acid is the main active ingredient of the natural plant licorice. It is widely used in the field of medical cosmetics. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/14A61K8/86A61K8/63A61K8/34A61Q19/00
CPCA61K8/14A61K8/345A61K8/63A61K8/86A61K2800/10A61K2800/49A61K2800/52A61K2800/82A61Q19/00
Inventor 张婉萍杨雪芳贾红娇朱海洋
Owner SHANGHAI INST OF TECH
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