Liposome preparation for blacking hair and preparation method of liposome preparation

A technology of liposome and black hair, which is applied in the field of medicine, can solve the problems of insufficient penetration rate and penetration volume

Pending Publication Date: 2021-01-22
陕西中鸿科瑞再生医学研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the existence of the stratum corneum of the skin, most drugs cannot be directly absorbed by the human body, and the effective penetration rate and penetration volume cannot be achieved. Therefore, it is critical to use appropriate methods to increase the transdermal volume of drugs.

Method used

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  • Liposome preparation for blacking hair and preparation method of liposome preparation
  • Liposome preparation for blacking hair and preparation method of liposome preparation
  • Liposome preparation for blacking hair and preparation method of liposome preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0060] This embodiment provides a liposome black hair spray that promotes scalp health and can make gray hair black. Described liposome black hair spray comprises the composition of weight ratio described in the following table:

[0061] The formula of the liposome black hair spray of table 1 embodiment 1

[0062] Element Percent content Phospholipids / Cholesterol 3.5％ melanin 2％ copper peptide 0.01％ superoxide dismutase recombinant plasmid 0.001％ epidermal growth factor 0.001％ basic fibroblast growth factor 0.001％ anthocyanin 2％ TAT 0.001％

[0063] The preparation method of the liposome black hair spray provided by this embodiment is as follows:

[0064] 1. Preparation of Phospholipid Liposome Membranes

[0065] Add egg yolk lecithin and cholesterol with a mass ratio of 10:1 to 4-6 times the amount of absolute ethanol, dissolve at 45-60°C, and rotate the dissolved solution to form a uniform film ; or directly u...

Embodiment 2

[0082] This embodiment provides a liposomal hair spray that promotes scalp health and darkens hair. Described liposome black hair spray comprises the composition of weight ratio described in the following table:

[0083] The formula of the liposome black hair spray of table 3 embodiment 2

[0084] Element specific content Phospholipids 3.5％ melanin 4％ copper peptide 0.01％ catalase recombinant plasmid 0.001％ epidermal growth factor 0.001％ basic fibroblast growth factor 0.001％ Vitamin C 2％ TAT 0.001％

[0085] The preparation method of the liposome black hair spray provided by this embodiment is as follows:

[0086] 1. Preparation of Phospholipid Liposome Membranes

[0087] Add egg yolk lecithin to 4-6 times the amount of absolute ethanol, dissolve at 45-60°C, and rotate the dissolved solution to form a uniform film;

[0088] 2. Preparation of Aqueous Phase

[0089] Preparation of solution A: Weigh 10g of water-s...

Embodiment 3

[0103] Carry out the preparation of liposome black hair spray according to the prescription in the table respectively.

[0104] The formula of the liposome black hair spray in the embodiment 3 of table 5

[0105]

[0106] Preparation:

[0107] Step a: Preparation of the aqueous phase

[0108] Preparation of solution A: weigh melanin, amino acid and trace elements, add to distilled water and stir for 5-20min, heat to dissolve, filter, add water to make up the volume; the mass ratio of melanin to amino acid is 1g:1-3g, and the amino acid is One or more of L-arginine, DL-arginine or DL-histidine; wherein, the amount of trace elements added in prescription 1: ferrous sulfate 15 μmol / L, zinc sulfate 20 μmol / L; The amount of trace elements added in prescription 2: copper gluconate 10-20 μmol / L; the amount of trace elements added in prescription 3: zinc gluconate 10-20 μmol / L; no trace elements were added in prescription 4-5.

[0109] Preparation of solution B: Weigh an appropr...

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Abstract

The invention relates to a liposome preparation for blackening hair and a preparation method of the liposome preparation. The liposome preparation is prepared from melanin, trace elements, protein polypeptide components for recovering normal metabolism of melanin, nucleic acid components for enhancing or repairing hair follicle genes, antioxidant related genes and / or cytokines beneficial to hair follicle health and the like efficiently. Functional biomacromolecules such as protein DNA are encapsulated by adopting liposome, so that the transdermal absorption efficiency can be greatly improved,normal metabolism of hair follicle melanin is effectively promoted, the scalp hair follicle health is maintained, and the blackening of white hair is promoted. Effective components, especially biomacromolecules, are wrapped by lipidosome, so that the transdermal absorption effect and the normal-temperature storage stability are greatly improved, the effective components can be accumulated on the epidermal layer of the skin, a long-acting slow-release effect is achieved, the local drug concentration is increased, and the treatment effect is enhanced. The liposome is similar to natural microcapsules in a human body in size and structure, has the characteristic of hair follicle affinity, targets hair follicles, and has the effects of promoting hair blacking and maintaining scalp health.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a liposome preparation for black hair and a preparation method thereof. Background technique [0002] With the increase of age, the human body undergoes physiological aging, and the hair changes from black to white is a natural aging feature. However, affected by environmental pollution and work and life pressure, the proportion of gray hair is gradually increasing, and it is obviously younger. Hair diseases such as premature gray hair seriously affect personal image and social activities. [0003] Gray hair is caused by the melanin generation and pigmentation of hair follicle melanocytes, which are related to various factors such as nutrition, heredity, bad living habits, emotions, and environment. The main disease mechanism of gray hair that can be confirmed by modern medicine is that the proliferation of hair follicle melanocytes is inhibited, and the activity o...

Claims

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Application Information

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IPC IPC(8): A61K38/44A61K9/12A61K9/127A61K47/18A61P17/00A61K31/404A61K33/34A61K33/26A61K33/30A61K33/04A61K33/06A61K38/06A61K38/10A61K38/18A61K38/19
CPCA61K31/404A61K33/34A61K33/26A61K33/30A61K33/04A61K33/06A61K38/06A61K38/10A61K38/1808A61K38/1866A61K38/18A61K38/19A61K38/44A61K38/446A61K9/12A61K9/0014A61K9/127A61K47/18C12Y110/03001C12Y115/01001C12Y111/01006C12Y111/01009A61P17/00A61K2300/00
Inventor 王哲明磊国王清霞
Owner 陕西中鸿科瑞再生医学研究院有限公司
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