Polyethylene glycol-modified thymus peptide 1 derivatives

CN1690079AInactive Publication Date: 2005-11-02JIANGSU HANSOH PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JIANGSU HANSOH PHARMA CO LTD
Publication Date
2005-11-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the method for producing long-acting thymus peptide 1 derivant and its salt for medical use, and the usage of them. The long-acting thymus peptide derivant is consisting of thymus peptide derivant and carbowax with covalent links, of which the structure is showed as the instruction defined. The prosoma thymus peptide 1 derivant modifying carbowax can be produced by the means of chemosynthesis and restructuring DNA.
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Description

technical field

[0001] The present invention relates to the preparation and application of long-acting thymosin 1 derivatives. It specifically relates to polyethylene glycol-modified thymosin 1 derivatives. technical background

[0002] The thymus is an important immune organ in the body and plays an important role in the development of the lymphatic system and maintaining the normal function of the immune system. Especially, it has special significance in anti-infection, anti-tumor, autoimmune diseases and organ transplantation. As the body ages, the thymus gradually shrinks and degenerates, and the incidence of tumors, infections, and immune diseases gradually increases. In recent years, foreign scholars have purified thymosin into several individual components, and found that the biological activity of thymosin 1 is 10-1000 times higher than that of thymosin mixture. Thymosin 1 belongs to the fifth component of thymosin, which has an immunoregulatory effect. It can ind...

Claims

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