Hernia patch solid-supported with antibiotic and preparation method

A technology of antibacterial drugs and patches, applied in antibacterial drugs, medical science, powder delivery, etc., to achieve high drug loading, mature technology, and non-immunogenic effects

Inactive Publication Date: 2011-10-05
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In terms of the preparation method of drug controlled / sustained-release preparations, the emulsion-solvent evaporation method is a classic method for preparing polymer drug carriers. This method is used to prepare drug-loaded microspheres and immobilize them on the patch to prepare an antibacterial hernia repair patch. No report

Method used

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  • Hernia patch solid-supported with antibiotic and preparation method
  • Hernia patch solid-supported with antibiotic and preparation method
  • Hernia patch solid-supported with antibiotic and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Norvancomycin microspheres were prepared by double emulsion solvent evaporation method. Aqueous norvancomycin hydrochloride (20 mg / ml) was used as the inner aqueous phase; PLGA was dissolved in CH 2 Cl 2 Forming a concentration of 1% PLGA solution as the oil phase; adding the inner water phase to the oil phase at a volume ratio of 1:6, at room temperature, a high-pressure homogenizer is homogenized at a speed of 5000rpm for 30s to form colostrum (W / O); PVA (PVA 05-88, the same below) is used as an emulsifier, and the concentration of 1% PVA aqueous solution is prepared as the external water phase; the colostrum is poured into the external water phase, and the volume ratio of the colostrum to the external water phase is 1: 3. Form double emulsion (W / O / W), stir at room temperature with a constant speed mixer at 200rpm for 2h, volatilize the organic solvent, centrifuge, wash, freeze (speed 1000rpm, centrifuge for 10min, gradient cooling and drying at 20°C for 2h, 10°C for...

Embodiment 2

[0072] Cut the blank patch (polypropylene patch PCDM 1.01, Ethicon, U.S.) into a square, place it in 1% EVA cyclohexane solution for full infiltration, accurately weigh 30 mg of norvancomycin microspheres, and place the drug-loaded microspheres The balls were evenly dispersed on the patch, placed to dry, and the surface of the patch containing norvancomycin microspheres was obtained to be smooth, and the microspheres and the patch were not damaged, as shown in Fig. figure 2 . The accumulative release rate reaches 72.6%, and it can be released continuously for more than 28 days. It has obvious slow-release effect, such as image 3 . Forty SD rats were randomly divided into two groups, 20 in each group; they were the experimental group and the control group. After intraperitoneal injection of pentobarbital sodium anesthetized the two groups of rats, a longitudinal incision about 1 cm long was made in the middle of the back to reach the subcutaneous layer and free the subcutan...

Embodiment 3

[0074] Cut the polypropylene patch (polypropylene patch PCDM 1.01, Ethicon, USA) into a 1cm×1cm square, smear 0.25% EVA (FM 114.1, d 0.941) cyclohexane solution on the surface, volatilize at room temperature, and wait until it is completely When drying, accurately weighed norvancomycin hydrochloride (NV) is uniformly dispersed on its surface, and then the cyclohexane solution of EVA is put into a polytetrafluoroethylene tank by volatile casting method, and placed at room temperature to dry ) prepared EVA film, covering the surface ( Figure 8 ). The in vitro release results show that the cumulative release rate of the drug-loaded patch reaches 90.6%, and it can be released continuously for more than 24 hours, and has obvious sustained release effect (such as Figure 9 ).

[0075] Twelve Wistar rats were randomly divided into two groups, 6 in each group; they were the experimental group and the control group, respectively. After intraperitoneal injection of pentobarbital sod...

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Abstract

The invention relates to a hernia patch solid-supported with antibiotics and a preparation method. The antibiotic hernia patch solid-supported with drug-loaded microspheres comprises drug-loaded microspheres, a patch, and a supporting agent. The sandwich-type antibiotic hernia patch comprises a patch layer, a drug layer, and a film layer. The antibiotic hernia patch solid-supported with drug-loaded microspheres is prepared by solid-supporting the drug-loaded microspheres onto the surface of the patch material by the supporting agent. The drug-loaded microspheres are loaded with water-soluble drugs by a solvent evaporation method. The sandwich-type antibiotic hernia patch is prepared by sandwiching the drug layer between the patch layer and the film layer through a layer-by-layer superposition principle. The antibiotic hernia patch of the invention has a simple and practical preparation method, is suitable for different clinical medication requirements, has obvious slow release performance, has significant antibiotic effect in rats, solves the problem of acute and delayed infection after herniorrhaphy, has good market prospects, and is worthy of popularization and utilization.

Description

Technical field: [0001] The invention relates to a hernia prosthesis immobilized with antibacterial drugs and a preparation method thereof. Background technique: [0002] Tension-free hernia repair uses artificial materials as a patch to strengthen the posterior wall of the inguinal canal. This method creates tension in the surrounding tissue after repair, reducing the occurrence of infection, recurrence, and pain. Tension-free hernia repair has become the main routine procedure for repairing all kinds of hernias. The patch is divided into two categories: biological material patch and biological patch, and the former is mostly used. Biomaterial patches use polymer as the main basic material, and there are three main types: polypropylene, polyester and polytetrafluoroethylene, among which polypropylene material (PP) is the current research hotspot. [0003] Polypropylene mesh filling hernia repair is a safe and effective method for the treatment of inguinal hernia. It has t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/16A61L27/18A61L27/20A61L27/24A61K9/14A61K47/34A61P31/04
Inventor 刘天军高丽丽王琼
Owner INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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