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Preparation method of chimonanthus nitens valid target, production method and use of formulation thereof

A technology of effective parts and waxberry, which is applied in the field of preparation of effective parts of waxflower, can solve the problem that the pharmacological action is not very clear, and achieve the effect of being rich in active ingredients and taking a small amount

Active Publication Date: 2009-02-04
江西佑美制药有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The above studies have shown that the volatile oil and extracted extract of Waxburghiae have antibacterial, anti-inflammatory, antipyretic, antitussive, anti-influenza virus and immune enhancement effects, but it is not very clear which components or parts play the above pharmacological effects, so It is necessary to study the active ingredients and effective parts of Waxweed in depth, so as to guide the development of new preparations with more significant curative effect

Method used

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  • Preparation method of chimonanthus nitens valid target, production method and use of formulation thereof
  • Preparation method of chimonanthus nitens valid target, production method and use of formulation thereof
  • Preparation method of chimonanthus nitens valid target, production method and use of formulation thereof

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Effect test

Embodiment 1-1

[0019] A method for preparing effective fractions of Waxburgh chinensis, the method sequentially includes the following steps:

[0020] Step (1) Sorting and drying the waxberry leaves, soaking them in water for 30 minutes, steam distillation to extract the volatile oil, collecting the volatile oil, drying it with anhydrous sodium sulfate, and using it as the effective part of the volatile oil;

[0021] Step (2) The distilled aqueous solution is stored in another device; the dregs are extracted with a solvent, filtered, and the extract is collected, combined with the distilled aqueous solution, concentrated under reduced pressure, and the concentrated solution is adsorbed on a macroporous resin chromatography column, and the column is doubled. Elute with volume water, discard the water washing solution, continue to elute with 10% ethanol of 2 times the column volume, discard the eluent, continue to elute with 30% ethanol for 2 times the column volume, collect the eluent, and dep...

Embodiment 1-2

[0024] A method for preparing effective fractions of Waxburgh chinensis, the method sequentially includes the following steps:

[0025] Step (1) Sorting and drying the waxberry leaves, soaking them in water for 60 minutes, steam distillation to extract the volatile oil, collecting the volatile oil, drying with anhydrous sodium sulfate, and using it as the effective part of the volatile oil;

[0026] Step (2) The distilled aqueous solution is stored in another device; the dregs are extracted with a solvent, filtered, and the extract is collected, combined with the distilled aqueous solution, concentrated under reduced pressure, and the concentrated solution is adsorbed on a macroporous resin chromatography column, and the condensed solution is absorbed by a 6-fold column Elute with volume water, discard the water washing solution, continue to elute with 30% ethanol of 6 times the column volume, discard the washing solution, continue to elute with 90% ethanol of 6 times the colum...

Embodiment 1-3

[0029] A method for preparing effective fractions of Waxburgh chinensis, the method sequentially includes the following steps:

[0030] Step (1) Sorting and drying the waxberry leaves, soaking in water for 45 minutes, steam distillation to extract the volatile oil, collecting the volatile oil, drying with anhydrous sodium sulfate, and using it as the effective part of the volatile oil;

[0031] Step (2) The distilled aqueous solution is stored in another device; the dregs are extracted with a solvent, filtered, and the extract is collected, combined with the distilled aqueous solution, concentrated under reduced pressure, and the concentrated solution is adsorbed on a macroporous resin chromatography column, and the chromatographic column is used for three times. Elute with volume water, discard the water washing solution, continue to elute with 3 times column volume of 60% ethanol, discard the eluent, continue to use 3 times column volume for elution with 60% ethanol, collect ...

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Abstract

The invention relates to a preparation method of effective fractions of shining wintersweet leaf, a preparation method and a use of a preparation thereof, in particular to an application of the effective fractions of the shining wintersweet leaf and the preparation thereof in drugs used for preventing and treating respiratory system diseases as well as in anti-cold drugs, antimicrobial drugs, anti-inflammation drugs, antiviral drugs, antifungal drugs, etc. In the invention, the volatile effective fractions and non-volatile effective fractions are added to the crude drug of the shining wintersweet medicinal material with a weight ratio of the actual extraction amount of the shining wintersweet to the effective fractions being 1.0-2.6:0.5-3.5, thus the effective fractions of the shining wintersweet leaf are obtained. A preparation of the effective fractions of the shining wintersweet can be made into granules, soft capsules, capsules, drop pills, tablets, compound capsules, dispersible tablets, etc. In the invention, the preparation of the shining wintersweet is deeply developed, which ensures that the preparation is rich in active ingredients, has definite effective ingredients, obvious pharmacological action and significant improvement of drug action. Besides, the preparation has stable performance and controllable quality, is safe and reliable, has less dosage, and is favorable for transportation and storage of the medicine as well as for patients to take.

Description

technical field [0001] The present invention relates to a medicine with effective parts of traditional Chinese medicine, in particular to a preparation method of effective parts of Waxweed, and the content of detectable active ingredients in the effective parts can reach more than 50%; It can be used in respiratory diseases, anti-cold, antibacterial, anti-inflammatory, antiviral and antifungal drugs. Background technique [0002] Influenza is the most common disease in the world. It is divided into two types: influenza and common cold. Influenza can easily cause virus mutation, and may lead to viral pneumonia, viral myocarditis and other diseases; the symptoms caused by cold are mainly fever, Cold, runny nose, cough. According to statistics, the highest proportion of self-diagnosis and treatment of common diseases in China is cold, accounting for 89.6% of common diseases. 75% of people suffer from a cold once a year, that is to say, there are about one billion colds in a y...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/16A61K9/20A61K9/48A61P11/00A61P31/04A61P31/10A61P31/12A61K127/00
Inventor 范玫玫杨世林王跃生黄勇罗晓健张小娟洪汉斌
Owner 江西佑美制药有限公司
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