Veterinary antibacterial drug composition containing lysozyme and oligosaccharide and application thereof

An oligo-oligosaccharide and antibacterial drug technology, applied in the field of medicine, can solve the problems of decreased curative effect, lost curative effect, increased dosage, etc., and achieves the effects of enhancing immunity, particularly effective, and broad antibacterial spectrum.

Inactive Publication Date: 2011-01-05
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past 50 years, due to the long-term use of antibiotics, a large number of drug-resistant strains have been produced, and the resistance of pathogenic bacteria has increased year by year, resulting in a decline in efficacy and an increase in dosage.
Therefore, in 1994, the World Health Organization warned the world about the results of bacterial drug resistance surveillance: bacterial resistance to antibiotics is increasing at an alarming rate, and existing antibiotic drugs are losing their original efficacy

Method used

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  • Veterinary antibacterial drug composition containing lysozyme and oligosaccharide and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A drug combination containing lysozyme, oligosaccharides and doxycycline hydrochloride for the treatment of respiratory antibiotics:

[0025] Lysozyme 150g Oligosaccharides 50g

[0026] Doxycycline Hydrochloride 20g Biotin 0.5g

[0027] Phytic acid 2g trehalose 15g;

[0028] Glycine 10g Water-soluble Vitamin E 1g

[0029] Potassium dihydrogen phosphate 6g Disodium edetate 15g

[0030] Carboxymethylcellulose sodium 10g anhydrous glucose added to 1000g

[0031] Preparation process:

[0032] 1. Weigh biotin and water-soluble vitamin E and add anhydrous glucose to dilute 6 times respectively to obtain two kinds of basically mixed and uniform mixtures.

[0033] 2. Weigh phytic acid and anhydrous glucose and dilute it 3 times by equal volume incremental dilution method to obtain a basically uniformly mixed mixture;

[0034] 3. The above mixture is mixed with the remaining oral glucose and other raw and auxiliary materials, and passed through a 60-mesh fine sieve twice t...

Embodiment 2

[0036] A drug combination containing lysozyme, oligosaccharides and florfenicol for the treatment of intestinal antibiotics:

[0037] Lysozyme 50g Oligosaccharides 150g

[0038] Florfenicol 20g Biotin 0.2g

[0039] Phytic acid 1g trehalose 10g;

[0040] Glycine 12g Water-soluble Vitamin E 0.8g

[0041] Potassium dihydrogen phosphate 8g Disodium edetate 10g

[0042] Carboxymethylcellulose sodium 12g Anhydrous glucose added to 1000g

[0043] Preparation process:

[0044] 1. Weigh biotin, water-soluble vitamin E, and phytic acid and add anhydrous glucose to dilute 6 times respectively to obtain 3 basically mixed and uniform mixtures.

[0045] 2. The above mixture is mixed with the remaining oral glucose and other raw and auxiliary materials, and passed through a 60-mesh fine sieve twice to obtain the product.

Embodiment 3

[0047] The present invention will be further described below through clinical application examples.

[0048] In a chicken farm in Shandong Province, broiler chickens aged 10 to 15 days showed malaise, loose feathers, loss of appetite, yellow-green loose stools, yellow cheese-like substances on the liver and heart surface in the abdominal cavity, cloudy and thickened air sacs, peritoneum Turbidity, intestinal lymphoid follicles have hemorrhagic protrusions, glandular stomach papilla swelling, diagnosed as gallisepticum Escherichia coli disease accompanied by mild chicken atypical Newcastle disease.

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Abstract

The invention relates to a veterinary antibacterial drug composition containing lysozyme and oligosaccharide and an application thereof. The composition can be prepared into powder, granules, premixes, suspensions and oral solutions by mixing a pharmaceutically acceptable drug carrier with the main drugs of the lysozyme, the oligosaccharide and an antibacterial drug, as well as the auxiliary ingredients of biotin, phytic acid, trehalose, glycine and the like which are used for coordination, according to a conventional preparation method. The composition not only can enhance the self immunity of animals, equalize the absorption of amino acids and mineral substances in vivo and broaden the antimicrobial spectrum, but also has high efficiency, safety and no toxic and side effect and is not easy to lead to drug tolerance and drug resistance. The composition is used for preventing and treating intestinal diseases and respiratory diseases, such as colibacillosis, salmonellosis, pasteurella multocida, staphylococosis and the like, of livestock and poultry. Meanwhile, the developed drugs can be used for effectively substituting the traditional veterinary antibiotic drugs which are easy to lead to drug tolerance.

Description

technical field [0001] The invention belongs to the technical field of medicines, and is a veterinary antibacterial drug combination containing lysozyme and oligosaccharides, which is used for preventing and treating intestinal diseases or respiratory diseases of livestock and poultry, such as colibacillosis, salmonellosis, Gastroenteritis, Pasteurella multocida, Staphylococcal disease, etc. Background technique [0002] Today in the 21st century, the development of drug-resistant bacteria is shocking. The so-called drug-resistant bacteria are bacteria that develop resistance to drugs. After the bacteria have been in contact with the drug for many times, their sensitivity to the drug decreases or even disappears, resulting in a decrease in the sensitivity of the drug to the bacteria or even ineffectiveness. [0003] Antibiotics are the most widely used antibacterial drugs, not only for clinical use, but also for livestock and poultry feeding and agriculture. In the past 50...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/48A61K38/46A61K45/00A61P31/04A61P1/00A61P11/00A61K31/702A61K31/4188A61K31/198A61K31/7016
Inventor 马丽伟
Owner TIANJIN RINGPU BIO TECH
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