Dihydroisoquinoline compounds and application of dihydroisoquinoline compounds for preparing antibacterial agents for plants

Abstract

The invention relates to dihydroisoquinoline compounds and an application of the dihydroisoquinoline compounds for preparing antibacterial agents for plants. The dihydroisoquinoline compounds have remarkable bacteriostatic activity on various phytopathogens. The dihydroisoquinoline compounds disclosed by the invention have the molecular structure characteristics shown as follows, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are same or different groups, such as hydrogen, alkyl, cycloalkyl, alkenyl, alkinyl, unsaturated monocycloalkyl, alkoxyl, halogen, hydroxyl, nitryl, cyano, trifluoromethyl, heterocyclic substituent, carboxyl, ester group, acylamino, acyl or aldehyde group; and X<-> is sulfate radical, halogen anion, carbonate radical, bicarbonate radical, phosphate radical, hydrophosphate radical, acid radical of fatty acid, sulfonate radical or tetraphenylborate radical.

Description

1. Technical field: [0001] The invention relates to a class of dihydroisoquinoline compounds and their application as preparation of plant antibacterial drugs. 2. Background technology: [0002] In nature, there is a class of positively charged carbon-nitrogen double bonds (—C=N + -) alkaloids, such as berberine, sanguinarine, chelerythrine, etc. The molecules of these compounds all have isoquinoline structural units, and belong to the generalized isoquinoline alkaloids. Pharmacological activity studies have proved that such alkaloids generally have anticancer and antimicrobial activities. The study of structure-activity relationship shows that the carbon-nitrogen double bond (—C=N) in this kind of alkaloid + -) is the determining group of its activity. However, the following two factors greatly limit the application of this type of compound. First, the chemical properties of this class of alkaloids are relatively active, and it is easy to interact with many nucleophile...

AI Technical Summary

Problems solved by technology

In addition, so far, there is no research report on any biological activity of the compounds involved in this patent

Images