Dihydroisoquinoline compounds and application of dihydroisoquinoline compounds for preparing antibacterial agents for plants

A dihydroisoquinoline and plant antibacterial technology, which is applied in the application field of preparing plant antibacterial drugs, can solve problems such as research reports on the biological activity of compounds that have not been seen, and achieve the effects of low production cost, simple structure, and easy synthesis

Inactive Publication Date: 2012-07-25
NORTHWEST A & F UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, so far, there is no research report on any biological activity of the compounds involved in this patent

Method used

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  • Dihydroisoquinoline compounds and application of dihydroisoquinoline compounds for preparing antibacterial agents for plants
  • Dihydroisoquinoline compounds and application of dihydroisoquinoline compounds for preparing antibacterial agents for plants
  • Dihydroisoquinoline compounds and application of dihydroisoquinoline compounds for preparing antibacterial agents for plants

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Embodiment Construction

[0013] A class of dihydroisoquinoline compounds involved in the present invention and their application as preparation of plant antibacterial drugs are characterized in that they have the following molecular structure characteristics:

[0014]

[0015] Among them, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 are the same or different and represent hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, unsaturated monocyclic hydrocarbon, alkoxy, halogen, hydroxyl, nitro, trifluoromethyl, heterocyclic substitution group, carboxyl group, ester group, amido group, acyl group, aldehyde group.

[0016] x - It is sulfate, halogen anion, carbonate, bicarbonate, phosphate, hydrogen phosphate, fatty acid acid, sulfonate.

[0017] As the application of dihydroisoquinoline compounds in the preparation of plant antibacterial drugs, it is known that dihydroisoquinoline compounds have significant inhibitory activity on the following plant pathogens: Curvul...

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Abstract

The invention relates to dihydroisoquinoline compounds and an application of the dihydroisoquinoline compounds for preparing antibacterial agents for plants. The dihydroisoquinoline compounds have remarkable bacteriostatic activity on various phytopathogens. The dihydroisoquinoline compounds disclosed by the invention have the molecular structure characteristics shown as follows, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are same or different groups, such as hydrogen, alkyl, cycloalkyl, alkenyl, alkinyl, unsaturated monocycloalkyl, alkoxyl, halogen, hydroxyl, nitryl, cyano, trifluoromethyl, heterocyclic substituent, carboxyl, ester group, acylamino, acyl or aldehyde group; and X<-> is sulfate radical, halogen anion, carbonate radical, bicarbonate radical, phosphate radical, hydrophosphate radical, acid radical of fatty acid, sulfonate radical or tetraphenylborate radical.

Description

1. Technical field: [0001] The invention relates to a class of dihydroisoquinoline compounds and their application as preparation of plant antibacterial drugs. 2. Background technology: [0002] In nature, there is a class of positively charged carbon-nitrogen double bonds (—C=N + -) alkaloids, such as berberine, sanguinarine, chelerythrine, etc. The molecules of these compounds all have isoquinoline structural units, and belong to the generalized isoquinoline alkaloids. Pharmacological activity studies have proved that such alkaloids generally have anticancer and antimicrobial activities. The study of structure-activity relationship shows that the carbon-nitrogen double bond (—C=N) in this kind of alkaloid + -) is the determining group of its activity. However, the following two factors greatly limit the application of this type of compound. First, the chemical properties of this class of alkaloids are relatively active, and it is easy to interact with many nucleophile...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D217/02C07D217/04C07D217/12A01N43/42A01P3/00
Inventor 周乐马艳妮杨新娟苗芳
Owner NORTHWEST A & F UNIV
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