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Composition for inhibiting alpha-glucosidase and application of composition

A technology of glucosidase and composition, which is applied in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of limited blood sugar lowering effect of a single active ingredient, easy to produce drug resistance, etc., and achieve obvious synergy effects, dose reduction, and resistance-reducing effects

Active Publication Date: 2021-09-28
ZHENGZHOU FRUIT RES INST CHINESE ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a composition for inhibiting α-glucosidase and its application, so as to solve the problems in the prior art that the single active ingredient has limited hypoglycemic effect and easily produces drug resistance

Method used

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  • Composition for inhibiting alpha-glucosidase and application of composition
  • Composition for inhibiting alpha-glucosidase and application of composition
  • Composition for inhibiting alpha-glucosidase and application of composition

Examples

Experimental program
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Effect test

Embodiment 1

[0049] The composition of daidzein and dihydroquercetin, wherein the mass ratio of daidzein and dihydroquercetin is 8:25, and the specific concentrations of daidzein and dihydroquercetin in the composition are respectively 8 μg / mL and 25 μg / mL.

Embodiment 2

[0051] The composition of daidzein and dihydroquercetin, wherein the mass ratio of daidzein and dihydroquercetin is 8:30, and the specific concentrations of daidzein and dihydroquercetin in the composition are 8 μg / mL and 30 μg / mL.

Embodiment 3

[0053] The composition of daidzein and dihydroquercetin, wherein the mass ratio of daidzein and dihydroquercetin is 8:50, and the specific concentrations of daidzein and dihydroquercetin in the composition are 8 μg / mL and 50 μg / mL.

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PUM

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Abstract

The invention discloses a composition for inhibiting alpha-glucosidase and application of the composition and belongs to the technical field of natural active compounds. The composition disclosed by the invention comprises daidzein and a quercetin derivative, wherein the quercetin derivative is dihydroquercetin or 3-O-methyl quercetin; wherein the mass ratio of the daidzein to the dihydroquercetin is (8: 25)-(10: 25); and the mass ratio of the daidzein to the 3-O-methyl quercetin is (8: 2)-(8: 4). The composition disclosed by the invention has an obvious synergistic effect of inhibiting alpha-glucosidase, the effect of the composition is superior to that of single use of a flavone compound, the dosage of medicines can be reduced, and the occurrence of drug resistance is reduced.

Description

technical field [0001] The invention belongs to the technical field of natural active compounds, and in particular relates to a composition for inhibiting α-glucosidase and its application. Background technique [0002] The progress of the times has driven the rapid development of science and technology. People's living standards have also been continuously improved due to scientific progress, and people's eating habits have also undergone tremendous changes. Unscientific large intakes of high sugar, high protein, and high fat have led to some " The incidence of "diseases of wealth" has increased significantly, and diabetes is one of them. Diabetes is a global chronic metabolic disease, and it is still a lifelong disease that cannot be completely cured. The main feature of the disease is that the glucose concentration in the blood is at a high level for a long time and glucose can be detected in the urine. It is an important means to inhibit the rise of postprandial blood ...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P3/10
CPCA61K31/352A61P3/10A61K2300/00C07D311/04A61K9/0056A61K9/16
Inventor 刘杰超张强焦中高陈大磊潘俊坤张春岭刘慧杨文博吕真真
Owner ZHENGZHOU FRUIT RES INST CHINESE ACADEMY OF AGRI SCI
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