13 results about "Isobutyrates" patented technology

The invention discloses an Apiotrichum loubieri gene and an application of the Apiotrichum loubieri gene. Relates to the technical field of fermentation. The invention provides a specific strain and application thereof in reconstituted tobacco. According to the tobacco leaf extracting solution fermented by the bacterial strain, the content of esters such as 2, 2, 4-trimethyl-1, 3-pentanediol monoisobutyrate, dimethyl phthalate, tributyl phosphate, dihydroactinidiolide and methyl palmitate is remarkably increased, and the content of the esters such as 2, 2, 4-trimethyl-1, 3-pentanediol monoisobutyrate, dimethyl phthalate, tributyl phosphate, dihydroactinidiolide and methyl palmitate is remarkably increased; nine novel ester substances with aromatic smell, fruit fragrance, flower fragrance and other characteristic aromas are newly generated, and four phenolic aroma components are newly added. And the whole fragrance style is obviously enhanced. It is shown that the aroma-producing Apiotrichum loubieri AL-4 fermented tobacco enzyme extracting solution has good aroma-producing capacity, and through the combined effect of enzymolysis and fermentation, the aroma-producing Apiotrichum loubieri AL-4 fermented tobacco enzyme extracting solution is expected to play an important application value in the field of reconstituted tobacco raw material quality improvement.

The present application relates to a kind of 2,2,4,4-tetramethyl-1,3-cyclobutanedione preparation method.The present application first mixes isobutyric anhydride, small molecule alcohol and organic acid and carries out high-temperature cracking, so that isobutyric anhydride in it is cracked to generate isobutyric acid and dimethyl ethylene ketone, and the isobutyric acid generated simultaneously is esterified with small molecule alcohol under the action of organic acid to generate isobutyrate;The product after cracking is separated, and dimethyl ethylene ketone is absorbed using the isobutyrate obtained by separation, and dimerization is obtained 2,2,4,4-tetramethyl-1,3-cyclobutanedione.The present application can obtain higher yield under the same operating load, reduce the generation of carbon deposition and the corrosion to equipment in the reaction process, long running cycle, and low equipment investment.

The invention belongs to the technical field of concrete curing agents, and particularly relates to a rain-wash-proof surface-enhanced concrete curing agent, a curing coating as well as a preparation method and application of the rain-wash-proof surface-enhanced concrete curing agent. The curing agent comprises a component A and a component B, wherein the component A comprises a reinforcing agent and a penetrating agent, and the reinforcing agent is formed by compounding aluminum sulfate and sodium aluminate according to the mass ratio of (2-3): 1; the component B comprises a film-forming polymer matrix, 2, 2, 4-trimethyl-1, 3-pentanediol monoisobutyrate, an organic waterproof component, sodium silicate, titanium dioxide and deionized water, and the organic waterproof component is formed by compounding isobutyltriethoxysilane and potassium methylsilicate according to the mass ratio of (1.5-2.5): 1. The curing agent forms a reinforcing layer and a waterproof layer through staged spraying, endows newly poured concrete with early rain wash resistance, and has excellent water retention, hydrophobicity and heat reflection performance.

The application provides a zirconium oxide slurry and a preparation method and application thereof. The zirconium oxide slurry is prepared by mixing the following components in mass fractions: 80-85% of zirconium oxide, 1.6-3.6% of a dispersing agent, 7.89-14.58% of a photosensitive resin, 1.97-6.25% of a diluent, and 0.1-0.25% of a photosensitive initiator; wherein the diluent is 2,2,4-trimethyl-1,3-pentanediol diisobutyrate. The zirconium oxide slurry prepared by the application has a solid content of 80-85%, and simultaneously has low viscosity (45 DEG C, 2.0-3.0 Pa·S) and fluidity; under the light curing printing debinding procedure, the green body with a large volume is not prone to interlayer cracks or other irregular cracks.

This invention belongs to the field of organic synthesis technology and relates to a method for preparing (S)-4-(2,4-difluorophenyl)-2-(hydroxymethyl)pent-4-en-1-yl isobutyrate. 2,4-Difluoroiodobenzene reacts sequentially with allyl alcohol and tert-butyl chloroformate to obtain 2-(2,4-difluorophenyl)allyl tert-butyl carbonate. Under the action of a palladium catalyst and Sadphos chiral phosphine ligand, the 2-(2,4-difluorophenyl)allyl tert-butyl carbonate undergoes alkylation and reduction to obtain (S)-4-(2,4-difluorophenyl)-2-(hydroxymethyl)pent-4-en-1-yl isobutyrate. This invention utilizes a palladium catalyst and Sadphos chiral phosphine ligand to precisely construct a chiral center in one step, achieving an enantioselectivity of up to 99.4% and an overall yield of 65-70%. The operation is simple, the catalyst is recyclable, significantly reducing production costs and making it suitable for industrial production.

This invention provides a PHA dispersion emulsion, its preparation method, and its applications, belonging to the field of polymer materials. This invention aims to solve the technical challenge of simultaneously achieving ultra-low temperature natural film-forming properties, excellent post-film-forming comprehensive performance, and long-term storage stability in polyhydroxyalkanoate (PHA) aqueous dispersion systems, which cannot be simultaneously satisfied by existing technologies. Its core lies in the strict definition and combination of a PHA polymer with a specific molecular weight and polydispersity index range, a film-forming aid with a specific chemical structure (2,2,4-trimethyl-1,3-pentanediol monoisobutyrate), and a specific type of water-dispersible compatible aliphatic polyisocyanate crosslinking agent. Through the synergistic effect generated by this unique ternary combination, the minimum film-forming temperature of the emulsion prepared by this invention can be reduced to 6℃~10℃, it can form a film naturally without hot pressing, and the film exhibits excellent mechanical properties, water resistance, and adhesion, as well as excellent storage stability for at least one year.

The application provides a preparation process of an anti-virus drug monabiravir for treating COVID-19, which comprises adding a base, reacting 2'-3'-isopropylidene cytidine with isobutyric anhydride to obtain 5'-isobutyrate containing amide impurities; then treating the reaction mixture with p-toluenesulfonic acid monohydrate to deprotect the acetonide and obtain pure isobutyryl cytidine p-toluenesulfonic acid salt containing no amide impurities; converting the p-toluenesulfonic acid salt into a free base, and then reacting with hydroxylamine to obtain monabiravir.

The application provides a preparation of a hyperbranched polymer electrolyte in-situ initiated by a diaphragm and application thereof. The diaphragm is first grafted with bromo-isobutyric acid ester through acylation reaction by using the abundant hydroxyl groups on the surface of the cellulose diaphragm; then a precursor solution is obtained by mixing a polymer monomer A, a branching initiation monomer B, a catalyst, a ligand and a lithium salt electrolyte; finally, the grafted cellulose diaphragm is soaked in the precursor solution to make the grafted cellulose diaphragm swell fully, and the hyperbranched polymer electrolyte in-situ initiated by the diaphragm is obtained after in-situ thermal polymerization of the battery. The hyperbranched polymer electrolyte in-situ initiated by the diaphragm prepared by the method has the advantages of high safety, high room temperature ionic conductivity and excellent interface stability, and the hyperbranched polymer electrolyte also has the diaphragm function, thereby providing a new research idea and method for preparing a high-performance polymer electrolyte.

This invention belongs to the field of polymer material additive synthesis technology, specifically relating to a method for preparing a mixed environmentally friendly plasticizer base material rich in asymmetric esters, as well as the base material and the mixed environmentally friendly plasticizer. The method includes the following steps: (1) Preparation of esterification reactants: 2,2,4-trimethyl-1,3-pentanediol monoisobutyrate is mixed with benzoic acid, and an azeotropic dehydrating agent is added; (2) Addition of a composite reaction inhibition system: A composite Lewis acid catalyst and a binary composite antioxidant are added to the system; (3) Stepwise esterification and liquid-based gas stripping to remove water: An azeotropic dehydration reaction with stepwise temperature increase is carried out under a protective atmosphere; (4) Separation and purification: The crude reaction liquid obtained in step (3) is washed, and after removing light components, it is sent to a scraped film molecular evaporator for short-path distillation. The distillate on the condensation surface is collected to obtain the environmentally friendly plasticizer base material. This invention aims to improve the yield of asymmetric esters by combining the optimization of catalysts with the enhancement of hydrodynamic mass transfer.

This invention discloses a method for preparing chlorofibrate using sulfur hexafluoride (SF6). The method uses ethanol and p-chlorophenoxyisobutyric acid (p-chlorophenoxyisobutyric acid) as raw materials, with an alkaline substance as an additive. The reaction is carried out in a solvent under light irradiation in the presence of SF6 and a photocatalyst to obtain chlorofibrate. In this method, SF6 is activated under photocatalytic conditions, and the esterification reaction of p-chlorophenoxyisobutyric acid with SF6 decomposition products is achieved to obtain chlorofibrate. The SF6 decomposition products serve as a condensation reagent. This method effectively activates SF6, a greenhouse gas, and fully utilizes the SF6 decomposition products to achieve the esterification of p-chlorophenoxyisobutyric acid to obtain chlorofibrate, turning SF6 waste into a valuable resource. The raw materials required by this method are simple and readily available, the reaction conditions are simple, green, and energy-saving, and it has high application value.

The present invention provides a perfume composition containing a compound represented by the formula (1) as an active ingredient. (In formula (1), R1 represents a C2-4 linear or branched olefinic unsaturated hydrocarbon group, and R2 represents a C1-6 linear, branched, or cyclic alkyl group.)

This invention belongs to the field of organic synthesis technology and relates to a method for preparing the key chiral intermediate (S)-4-(2,4-difluorophenyl)-2-(hydroxymethyl)pent-4-en-1-yl isobutyrate of posaconazole. In an electrochemical cell, 1-[1-(bromomethyl)vinyl]-2,4-difluorobenzene and methyl 2-bromo-3-isobutyryloxypropionate are reacted in the presence of a chiral nickel catalyst, followed by reduction to obtain the target product. This invention achieves asymmetric coupling of allyl and alkyl radicals through an electrochemical redox process catalyzed by a chiral nickel catalyst, constructing the core carbon skeleton and chiral center in one step. This avoids the cumbersome operations of multi-step functional group transformation and protection, and the target product exhibits high enantioselectivity and high overall yield, significantly reducing production costs and making it suitable for industrial production.