69results about How to "Synthetic process safety" patented technology

The invention discloses an oil-based polyamide assistant emulsifier for drilling fluids, and a preparation method thereof. The oil-based polyamide assistant emulsifier is prepared through a dehydration polycondensation reaction of diacid anhydrides, polyalkenepolyamine and aliphatic acid, wherein a molar ratio of the diacid anhydrides to polyalkenepolyamine to aliphatic acid is 1:1:1.4-4. The emulsifier is a macromolecular polymer surfactant, per unit mass of the emulsifier contains more lipophilic and hydrophilic groups, and the emulsifying efficiency is high; hydrophilic groups in the molecular structure is an amido structure, so the emulsifier has good high-temperature resistance; and the emulsifier and a wetting agent have synergism, so the wetting reversal of solid phase surface is facilitated.

The invention discloses a preparation method of a polyamine inhibitor for drilling fluid. The method comprises the following steps: an amine compound of low molecular weight and heterocyclic compounds are reacted in a setting condition for synthesis, and the amine compound is one of triethylene tetramine, trimethylethylamine hydroxide, N-methylethylamine, and trimethylhexamethylenediamine; the heterocyclic compound is 1,2-epoxypropane or 2,3-epoxybutane or 1,3-epoxybutane; the setting condition is as follows: alkali metal is used as a catalyst, and the reaction temperature is 80-100 DEG C; charging mol ratio between the amine compound and the heterocyclic compound is 1:2.5; the mass ratio between the amine compound and the alkali metal catalyst is 1200:1. The inhibitor has high inhibition capability for shale, and has good compatibleness to other common drilling fluid additives; the inhibitor is nontoxic and environmentally friendly.

The invention discloses a preparation method of alkali metal intercalated transition metal disulfide, which is characterized by taking the disulfide as the intercalated subject and borohydride as the intercalated object and intercalating the alkali metal ions among the lamellae of the transition metal disulfide inorganic materials through hybridization reaction to prepare the compound of the alkali metal ion intercalated disulfide. Compared with the prior art, the method has safe and simple synthesis process, is convenient to operate, expands the interlamellar spacing of the disulfide, provides cheap and easily-obtained raw materials for synthesis of functional intercalated composite materials and has broad application prospect.

A synthetic technology of graphite oxide comprises the following steps: placing graphite powder, concentrated sulfuric acid, a persulfate and an oxide in a reaction container according to a ratio of the graphite powder to the concentrated sulfuric acid to the persulfate to the oxide of 5-30g:50-300ml:5-30g:3-30g, stir-mixing, carrying out ultrasonic treatment for 3-25min, stirring in a 20-200DEG C water or oil bath for 2-24h, allowing to stand for 1-16h, filtering, drying, adding the concentrated sulfuric acid having an amount 2-7 times higher than the previous amount of the concentrated sulfuric acid, carrying out the ultrasonic treatment for 3-150min, slowly adding potassium permanganate having an amount 1-7 times higher than the addition amount of the graphite powder, continuously stirring for 2-24h, adding deionized water having an amount equal to the secondary addition amount of the concentrated sulfuric acid under an ice bath cooling condition, stirring for 5-h, adding hydrogen peroxide while stirring until no bubbles appear to obtain a graphite oxide solution, filtering the graphite oxide solution, and drying to obtain the graphite oxide. The synthetic technology has the advantages of no pollution, high raw material utilization rate, simple preparation process, high oxide insertion degree, and easy operation.

The invention discloses a processing method for synthesizing lithium iron phosphate materials. The method comprises the following steps: (1), preparing nanometer lithium iron phosphate primary particles to obtain nanometer precursor particles LFP of a lithium iron phosphate precursor; (2), drying and carbon coating, and sufficiently grinding and stirring the precursor and carbon soot evenly; and (3) sintering lithium iron phosphate to obtain lithium iron phosphate cathode material. According to the invention, the nanometer primary particles can be obtained by using a coprecipitation method, isophoron is used as abstersion which has the advantages of high boiling point and strong dissolubility, reaction temperature in wet synthesis can be increased greatly, and the purity of LFP products can be improved. The synthetic method has the advantages that raw materials are rich, the price is low, the synthesis process is simple, easy, safe and reliable, the production cost is low, the yield is high, environment pollutions are avoided, and the products have better electrochemical performance.

The invention discloses an amide compound and medical application thereof as an STING inhibitor, and particularly relates to a compound shown as a formula I or a formula II or pharmaceutically acceptable salt or ester or solvate thereof, which can be used for preparing the STING inhibitor or medicine for inhibiting STING signal path activation and preparing medicine for preventing or treating STING mediated diseases.

The invention discloses a water-based polyurethane emulsion for heat-resistant transfer coatings and a preparation method thereof. The key points of the technical scheme are: the material composition comprising the following components by weight: 6-14% of oligomer polyol, 10-14.2% of diisocyanate , hydrophilic chain extender 1.2-1.6%, cross-linking agent 1.5-3%, acetone 16-18%, NMP 2-4%, amine chain extender 4.0-4.5%, catalyst 0.006-0.010%, ice pure water 43.69- 51.49%, neutralizer 0.8-1.2%. The present invention uses the main raw materials such as oligomer polyol, diisocyanate, hydrophilic chain extender, crosslinking agent and amine chain extender, and uses the two-step method of prepolymer method without increasing the cost of raw materials. A water-based polyurethane emulsion for a temperature-resistant transfer coating with good transferability and good temperature resistance is provided.

This invention discloses an antioxidant of p-methylphenol-dicyclopentadiene-styrene resin. The resin is white or yellowish powder, with an average molecular weight of 650-850, a melting point of 100-115 deg.C, an ash content of 0.05%, and an average particle size of 10-30 mum. The resin is soluble in aromatic solvents such as styrene, acetone and alcohols, while insoluble in water and fatty solvents. The resin can be used as a high-efficiency antioxidant in rubber products and polymers such as SBR and carboxylated SBR latex, ABS, NBR, BR, SBS, SIS and their derivatives. The resin can also be used in stability protection in the manufacture of the above rubber products and polymers.

The invention discloses a preparation method of vonoprazan fumarate. The preparation method includes: S1, dissolving 5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde (I) in organic solvent, mixing with methylamine alcohol solution for 6-8h to generate imine, reducing with metal borohydride for 1-2h, and performing post-treatment to obtain a compound according to a formula II; S2, dissolving the compound prepared in the step S1 according to the formula II, in organic solvent, performing ice bathing and mixing with Boc anhydride to allow reaction for 1-2h, and performing post-treatment to obtain a compound according to a formula III; S3, dissolving the compound prepared in the step S2 according to the formula III, in organic solvent, adding sodium hydride and crown ether, adding 3-pyridine sulfuryl chloride, mixing for reaction for 1-2h, and performing post-treatment to obtain a compound according to a formula IV; S4, reacting the compound prepared in the step S3 according to the formula IV, in trifluoroacetic acid and methylene dichloride solution to obtain a compound according to a formula V; and S5, dissolving the compound prepared in the step S4 according to the formula V, in organic solvent to be salified with fumaric acid, thereby obtaining the vonoprazan fumarate (VI). The preparation method has few side reactions and high intermediate purity and allows simple post-treatment.

The invention relates to the field of medicinal chemistry, and discloses a biphenyl derivative with PD-1 / PD-L1 inhibitory activity as well as a preparation method and application thereof. The invention further discloses a composition containing the biphenyl derivative with the PD-1 / PD-L1 inhibitory activity or the pharmaceutically acceptable salt of the biphenyl derivative and a pharmaceutically acceptable carrier of the biphenyl derivative, and an application of the composition in preparation of a PD-1 / PD-L1 inhibitor. The compound can be used for treating tumors.

The invention discloses a modified fatty acid type primary emulsion for high-temperature-resistant oil based drilling fluid and a preparation method of the modified fatty acid type primary emulsion. The modified fatty acid type primary emulsion for the high-temperature-resistant oil based drilling fluid consists of the following components: dicarboxylic anhydride, fatty acid and epoxy chloropropane, wherein the mass ratio of dicarboxylic anhydride to fatty acid is 1:20-1:30, and the mass of the epoxy chloropropane accounts for 15-25% of the mass of the fatty acid. The modified fatty acid type primary emulsion disclosed by the invention is obtained by modifying the fatty acid, has stronger emulsifying capacity and high temperature resistance, and has an effect of reducing the high-temperature high-pressure filtration losses of the oil based drilling fluid at the same time.