The invention relates to a preparation method for continuously synthesizing an
empagliflozin intermediate by using a microchannel reactor, and belongs to the technical field of
medicine synthesis. The invention provides a preparation method for continuously synthesizing an
empagliflozin intermediate by using a microchannel reactor, which comprises the following steps: mixing a compound (3S)-3-[4-[(2-chloro-5-iodophenyl) methyl] phenoxy]
tetrahydrofuran in a formula IV with a
solvent to obtain a solution a, mixing a compound bis (
pinacol diboron) in a formula III with a
solvent to obtain a solution b, and continuously synthesizing the
empagliflozin intermediate by using a microchannel reactor. Mixing acetyl bromoglucose as shown in the formula II with a
solvent to obtain a solution c, adjusting the flow rate of a double-
plunger high-pressure constant-flow
infusion pump, cooling a coil reactor of
continuous flow equipment, feeding the pre-cooled solution a and the pre-cooled solution b into the coil reactor at the same time, carrying out a
coupling reaction to obtain a solution d, mixing the solution c and the solution d, feeding the mixture into a microchannel reactor, and carrying out a reaction to obtain a product. After the reaction,
quenching, extracting and purifying to obtain a compound empagliflozin intermediate shown in the formula I; the method has the advantages of high product yield, high purity and the like.