Process for recovery of organic acids from aqueous solutions

An organic acid, aqueous solution technology, applied in the direction of organic chemistry, solution crystallization, chemical recovery, etc., can solve problems such as increasing the effect

Inactive Publication Date: 2003-07-02
EASTMAN CHEM CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

And when the above impurities are small for the desired organic acid, the above impurities may be concentrated in the process, further increasing their effect
[0023] From the above it is clear that current protonation methods are often ineffective for recovering the desired organic acids from solution
[0024] The second problem concerns the presence of other anions not associated with the desired organic acid
This method has a number of problems, such as the need for an additional crystallization step in order to isolate 2-keto-L-gulonic acid from an aqueous acidic medium followed by a conversion step such as esterification

Method used

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  • Process for recovery of organic acids from aqueous solutions
  • Process for recovery of organic acids from aqueous solutions
  • Process for recovery of organic acids from aqueous solutions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] After acidifying to pH about 2 with sulfuric acid, activated charcoal treatment and microfiltration to remove cells, carbon and other solids, 3031 grams of broth medium and the components listed in Table 1 were evaporated and crystallized at 10°C, and the broth was evaporated to The average concentration of soluble inorganics (K, Na and P) in the mother liquor or filtrate increased by a factor of 7.52 (relative to that in the starting material), and 2312.6 grams of distillate were recovered, vacuum filtered, washed with methanol, and after drying, 361.1 grams were recovered 86.6 wt% pure (anhydrous) KLG product, equivalent to recovery of 77.9% KLG. The components in the mother liquor are listed in Table 2. A comparison of the ratio of available protons to KLG was determined by charge balance in the stock (87.5%) versus in the mother liquor (60.9%), revealing that the protonation of the stock broth was not Sufficiently, even more protons are missing when KLG is crystalli...

Embodiment 2

[0107] Imitating the circulating mother liquor in the continuous crystallization process, 160 grams of the mother liquor from broth crystallization described in Example 1 was combined with 2441.2 grams of the same fresh raw material, and evaporated and crystallized at 10° C. The broth was evaporated until the average concentration of soluble inorganics (K, Na and P) in the mother liquor or filtrate increased by a factor of 6.00 (relative to that in the fresh material), 1772.2 g of distillate was recovered, vacuum filtered, washed with methanol, After drying, 185.23 grams of 85.9 wt% pure (anhydrous) KLG product was recovered, corresponding to a recovery of 41.8% KLG. The components in the mother liquor are listed in Table 2, revealing that the mother liquor of Example 1 was less protonated than the fresh feedstock (60.9% vs. 87.5%) and that the ratio of available protons to KLG was even lower than in the mother liquor. Low (43.5%) is not surprising, this insufficient protonati...

Embodiment 3

[0109] Acidification to pH about 2 using sulfuric acid, charcoal treatment and microfiltration to remove cells, carbon and other solids, contact with H-form cation exchange resin for further pretreatment and the same broth as fresh material in Examples 1 and 2, The broth components obtained are listed in Table 1, wherein 3000.5 grams carry out evaporative crystallization at 10 ℃, and the broth is evaporated to a factor of 4.90 (relative to that in the raw material) that the concentration of phosphorus in the mother liquor or filtrate increases, and 2240 grams of distillation are recovered. liquid, vacuum filtered, washed with methanol, and after drying, 215.0 g of 88.1 wt% pure (anhydrous) KLG product was recovered, corresponding to a recovery of 52.6% KLG. The composition of the mother liquor is listed in Table 2. Unlike Example 1, the ratio of available protons to KLG in the feedstock (112.1%) compared to that in the mother liquor (132.4%) reveals an excess of stock broth. P...

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Abstract

A process for recovering a desired organic acid from a solution includes the steps of: providing an aqueous solution including at least one desired organic acid or its acid anion; adjusting the proton concentration in the aqueous solution to a desired level, with the desired proton concentration being selected, at least in part, by the amount of available protons needed to associate with the acid anions of the desired organic acid(s) to be recovered and/or acid anions that are weaker than the desired organic acids; and recovering at least a portion of the at least one desired organic acid from the aqueous phase. The desired proton concentration can be based on the amount of available protons being greater than, less than or substantially equal, to the amount of protons needed to associate with the anion of the desired organic acid(s) and acid anions that are weaker than the desired organic acid(s).Specific examples of suitable organic acids include, but are not limited to, ascorbic, succinic, tartaric, glyconic, gulonic, citric, lactic, hialic, maleic, acetic, formic, gluconic pyruvic, propionic, butyric, itaconic acids and mixtures thereof. One embodiment of the present invention relates to the recovery of 2-keto-L-gulonic acid (KLG) from aqueous solutions such as fermentation baths.

Description

[0001] background of the invention thanks [0002] This invention was made with US Government support under Cooperative Research Agreement No. 70NANB5H1138 awarded by the Advanced Technology Program of the National Institute of Standards and Technology, and the US Government has certain rights in the invention. field of invention [0003] The present invention relates to an improved process for the recovery of organic acids from solution, particularly degradation-sensitive organic acids. background of the invention [0004] It is often desirable to recover organic acids from solutions, and in this regard, solutions containing organic acids can be produced from various chemical reactions and biological processes such as fermentation. [0005] A typical approach using acid recovery processing involves protonating the acid in the carboxylate or salt form to the desired pH. [0006] For example USP No. 4,191,841 teaches a process for the preparation of syrin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D9/02C07C51/43C07C51/47C07C59/215
CPCY10S435/896Y10S435/876C07C51/43Y10S435/803Y02P20/582C07C59/347
Inventor N·A·科林斯M·R·舍尔顿G·W·廷达尔S·T·佩里R·S·奥梅德拉C·W·辛克B·K·阿鲁穆加姆J·C·胡布斯
Owner EASTMAN CHEM CO
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