Sensor model supervisor for a closed-loop insulin infusion system

a closed-loop insulin infusion and sensor model technology, applied in the field of drug delivery systems, can solve the problems of less desirable use of traditional external infusion pumps and current pumps limited by the speed

Inactive Publication Date: 2014-03-06
MEDTRONIC MIMIMED INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0017]This summary is provided to introduce a selection of concepts in a simplified form that are further described below in the detailed description. This summary is not intended to identify key features or essential features of the claimed subject matter, nor is it intended to be used as an aid in determining the scope of the claimed subject matter.

Problems solved by technology

Although offering control, pump therapy can suffer from several complications that make use of traditional external infusion pumps less desirable for the user.
However, current pumps are still limited by the speed of the insulin they are using.

Method used

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  • Sensor model supervisor for a closed-loop insulin infusion system
  • Sensor model supervisor for a closed-loop insulin infusion system
  • Sensor model supervisor for a closed-loop insulin infusion system

Examples

Experimental program
Comparison scheme
Effect test

case a

[0433

[0434]If (tP is not in the time window (tR−tDiffmin:tR)), the following logic is checked.

If (CFmin ≦ CFR ≦ CFmax)  If (t−tRecent ≦ tR ≦ t)    If (tR−tDiffmax ≦ tP ≦ tR−tDiffmin)      If (CFmax ≦ CFP ≦ CFmax)        Calculate CFchange with CFR as the CFcurrent and        with CFP as the CFprevious in Equation 50 stated        above        If (CFchange ≦ CFchangeTh)          Enter Closed Loop        Else Cannot enter closed loop at that time      Else Cannot enter closed loop at that time    Else Cannot enter closed loop at that time  Else Cannot enter closed loop at that timeElse Cannot Enter Closed Loop

[0435]If any of the above conditions is not met, the system remains in the open-loop mode. Thus, in order to enter the closed-loop mode, new calibration(s) that satisfy all of the conditions in Case A (or Case B as described below) will be required.

case b

[0436

If (tP is in the time window (tR−tDiffmin : tR)),CFV = most recent CF value in the time window oftR−tDiffmax : tR−tDiffmintV = time when CFV was obtainedIf (CFmin ≦ CFR ≦ CFmax)  If there is a CFV available      Calculate CFchange with CFR as the CFcurrent and with      CFV as the CFprevious in Equation 50 stated above      If (CFV, CFR and all CF values between times tV and tR      lie in the range of (CFmin:CFmax) AND CFchange      between CFV and CFR is ≦ CFchangeTh)        Enter closed loop      Else Cannot enter closed loop at that time    Else Cannot enter closed loop at that time  Else Cannot enter closed loop at that timeElse Cannot Enter Closed Loop

[0437]If any of the above conditions is not met, the system remains in the open-loop mode. Thus, in order to enter the closed-loop mode, new calibration(s) that satisfy all of the conditions in Case A or Case B will be required.

[0438]In accordance with certain variations of the closed-loop initiation module 902, the system r...

case c

[0448

[0449]Case C corresponds to a scenario where the time of prior calibration is greater than 120 minutes before the most recent calibration. In addition, the recent calibration factor (CFR) and the prior calibration factor (CFP) are within limits as shown in the following logical expressions.

CFmin≦CFR≦CFmax  (eq A2)

CFmin≦CFP≦CFmax  (eq A3)

Here, CFR is the recent calibration factor value, CFP is the prior calibration value, CFmin is the minimum value for the calibration factor that is set as 2.5 mg / dL per nA, and CFmax is the maximum value for the calibration factor that is set as 6 mg / dL per nA.

[0450]For Case C, the time of recent calibration (tR) is within two hours of the start of closed-loop initiation as shown in the following logical expression.

t−tRecent≦tR≦t  (eq A4)

Here, tR is the time of recent calibration, t is the time when attempting to enter the closed-loop mode, and tRecent is the time window for the most recent calibration before attempting to start the closed-loop ...

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PUM

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Abstract

An electronic device includes a processor architecture and a memory element that stores instructions that, when executed by the processor architecture, perform a method of controlling an insulin infusion device for a user. The method operates the device in a closed-loop mode to deliver insulin to the user, obtains current insulin-delivered data and current glucose sensor data for the user, and processes historical insulin-delivered data and historical sensor data, to obtain predicted sensor glucose values for a historical time period. The method continues by calculating a difference between the current sensor glucose value and a predicted current sensor glucose value for the most recent sampling period. An alert is generated when the difference exceeds a threshold error amount.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of U.S. provisional patent application Ser. No. 61 / 694,950, filed Aug. 30, 2012 (titled “Closed Loop System”). This application also claims the benefit of U.S. provisional patent application Ser. No. 61 / 694,961, filed Aug. 30, 2012 (titled “Closed Loop Mobile System”). This application also claims the benefit of U.S. provisional patent application Ser. No. 61 / 812,874, filed Apr. 17, 2013 (titled “Closed Loop System”). The content of the provisional applications cited above is incorporated by reference herein.TECHNICAL FIELD[0002]Embodiments of the subject matter described herein relate generally to drug delivery systems and more specifically to systems for controlling the infusion rate of insulin based on state variable feedback.BACKGROUND[0003]The pancreas of a normal healthy person produces and releases insulin into the blood stream in response to elevated blood plasma glucose levels. Beta cells (β-ce...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61M5/172
CPCA61M5/1723A61B5/14503A61B5/14532A61B5/4839A61B5/746A61M5/172G06F19/3468G16H20/17G16H50/20G16H50/50A61M2230/201A61M2205/18A61M2205/582A61M2205/52A61M2205/502G16H40/40A61M2230/005G16H10/40
Inventor KEENAN, DESMOND BARRYMASTROTOTARO, JOHN J.GROSMAN, BENYAMINPARIKH, NEHA J.ROY, ANIRBAN
Owner MEDTRONIC MIMIMED INC
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