The invention provides a flexible lithium secondary battery, comprising a flexible battery shell, a battery main body and an electrolyte, wherein the battery main body is arranged in the flexible battery shell and comprises one or more sequentially stacked electrode units; each electrode unit comprises a positive plate, a flexible diaphragm and a negative plate, the positive plate, the flexible diaphragm and the negative plate are sequentially stacked, the positive plate comprises a positive current collector and a plurality of positive active material layers arranged on the positive current collector in an array type, the negative plate comprises a negative current collector and a plurality of negative active material layers arranged on the negative current collector in the array type, the positive plate and the negative plate have correspondingly arranged array interstitial vacancies, the correspondingly arranged array interstitial vacancies are applied to bending of a flexible lithium secondary battery in a plane two-dimensional direction, and the width of each array interstitial vacancy is 5-50mm. The flexible lithium secondary battery has the advantages that the integral flexibility is excellent, the energy density is high, the battery thickness, volume and mass are small, and the battery is suitable for flexible electronic products. The invention further provides a preparation method of the flexible lithium secondary battery.