The invention belongs to the technical field of mouse
neuroscience research, and relates to a multi-
modal mouse
virtual reality and nerve recording integrated
system based on
skull anchoring, which comprises a
skull anchoring basic support, a binocular miniature VR display module, a multi-
modal fixed expansion frame and a behavior and power supply platform. According to the invention, the
skull screw is used as a unique space reference, accurate limiting of the head is realized through rapid
butt joint of the MMA and the external fixing rod, and rapid plugging and coordinate
multiplexing of equipment for two-
photon imaging, optical genetic stimulation and the like are realized in combination with an M2 anchoring hole preset in the MMA; the total
mass of the whole
machine is strictly controlled within 3.2 g; the optical
system provides panoramic visual stimulation with a
horizontal field angle of 140 degrees, completely covers a key
binocular vision area on the top of the mouse head, and supports high-order cognitive task paradigms such as complex ecological
visual navigation,
spatial memory and social interaction.