Sustained-release agent containing antibiotic and uses thereof
A technology of antibiotics and sustained-release injections, applied in the field of medicine, can solve problems such as difficulty in obtaining effective bactericidal concentration, increased dosage and side effects, and achieve the effects of facilitating drug application, reducing the course of treatment, and overcoming limitations
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0111] Put 90, 90 and 80 mg of polyphenylpropane (p-carboxyphenylpropane (p-CPP): sebacic acid (SA) at 20:80) copolymers into (A), (B) and (C) three Add 100 milliliters of dichloromethane to each container, dissolve and mix well, add 10 mg carboxyphene penicillin, 10 mg flucloxacillin, and 20 mg mezlocillin respectively, and prepare 10% carboxylicin by spray drying after re-shaking. Thiophene penicillin, 10% flucloxacillin and 20% mezlocillin microspheres for injection. Then suspend the microspheres in physiological saline containing 15% mannitol to prepare the corresponding suspension-type sustained-release injection. The viscosity of the injection is 350cp-550cp (at 20°C-30°C). The drug release time of the slow-release injection in physiological saline in vitro is 6-12 days, and the drug release time in mice subcutaneous is about 14-22 days.
Embodiment 2
[0113] The method step of being processed into slow-release injection is identical with embodiment 1, but difference is that contained antibacterial active ingredient and weight percentage thereof are:
[0114] (1) 2-50% of penicillin, penicillin V, carboxyphene penicillin, procaine penicillin, nodosaur penicillin, carbapenem penicillin antibiotics, penicillin penicillin antibiotics, thiamycin, sulbenicillin, sulbenicillin sodium, furubicillin, ticarcillin, droperazine penicillin, oxypiperazine penicillin, mecillin, heptacillin, or heptacillin potassium;
[0115] (2) 2-50% of apacillin sodium, pimecillin, azlocillin, azlocillin sodium, apoxicillin, amcloxacillin sodium, azidecillin, flucloxacillin, flucloxacillin sodium, penicillin Alkanoic acid, varacillin sodium, oxacillin sodium, 1,3,4-thiadiazole carbapenem compound, methicillin or cloxacillin sodium;
[0116] (3) 2-50% oxacillin, oxacillin sodium, o-cloxacillin sodium, amoxicillin, piperacillin, piperacillin sodium, heba...
Embodiment 3
[0119] Put 70 mg of polylactic acid (PLGA, 75:25) with a peak molecular weight of 10,000 into three containers (A), (B) and (C) respectively, and then add 100 ml of dichloromethane to each, dissolve and mix well , add 30mg ampicillin, 30mg carbenicillin, 30mg mezlocillin into three containers respectively, shake again and prepare injection containing 30% ampicillin, 30% carbenicillin, 30% mezlocillin by spray drying method Use microspheres. The dried microspheres are suspended in physiological saline containing 1.5% sodium carboxymethylcellulose to prepare the corresponding suspension-type sustained-release injection. The viscosity of the injection is 400cp-600cp (at 20°C-30°C). The drug release time of the slow-release injection in physiological saline in vitro is 7-15 days, and the drug release time in mice subcutaneous is about 15-25 days.
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com