37 results about "Azlocillin Sodium" patented technology

The invention provided a method for preparing high-purity Mezlocillin sodium, and a method for preparing the Mezlocillin sodium powder injection. The method includes (1) dissolving Mezlocillin sodiumcrude product in purified water, and adjusting the pH value to less than 7 with the pH regulator; (2) extracting with organic solvent, separating the organic phase, drying with desiccant, and vacuum recovering to dry to obtain the product; (3) dissolving the product with eluting agent of mixed solution of hydrocarbon solvent and chlorine-containing solvent, eluting with alumina as filler of medium-pressure chromatography column, and collecting the fraction in a sectional manner; (4) mixing fractions with the Mezlocillin acid content of no smaller than 80%, vacuum concentrating, dissolving into ethanol, and basifying with base to separate precipitate; and (5) re-crystallizing the precipitate with ethanol, and freeze drying to obtain the high-purity Mezlocillin sodium.

The invention provides a preparation method of azlocillin sodium and azlocillin sodium used for injection, and the azlocillin sodium and the azlocillin sodium used for injection which can be prepared by the method. The method comprises the steps of: in a new solution system, leading ampicillin trihydrate to have a reaction with 1- chloroformyl-2-imidazolone under the optimized temperature condition, and producing high-quality azlocillin acid with higher reaction efficiency and yield; and directly salifying, sterilizing and freeze-drying the prepared azlocillin acid, and obtaining the azlocillin sodium product used for injection.

The invention discloses an azlocillin sodium crystal preparation and a preparation method thereof. The preparation method comprises the following steps: step 1, dissolving a crude azlocillin sodium product in a mixed solvent of methanol and ethyl methyl ketone, adding active carbon for adsorption, carrying out filtering, cooling the obtained filtrate to allow a crystal to be precipitated, washing the crystal with a mixed solution of methanol and ethyl methyl ketone and carrying out pressure-reduced drying so as to obtain a primary refined azlocillin sodium product; and step 2, dissolving the primary refined azlocillin sodium product in a hot ethyl methyl ketone solution, carrying out press filtration with a high-efficiency filter, subjecting obtained mixed liquor to cooling, pressure reduction and concentration, then carrying out cooling to allow a crystal to be precipitated and subjecting the precipitated crystal to filtering and pressure-reduced drying so as to obtain the azlocillin sodium crystal preparation. The azlocillin sodium crystal preparation provided by the invention has the advantages of a small particle size, uniform particle size distribution, good fluidity, simple crystallization process, low residual quantity of the organic solvent, high stability, good security, small toxic and side effects, low proneness to allergy, etc.

The invention relates to a crystal form of azlocillin sodium and a preparation method thereof. The crystal form is characterized by TGA characteristic peaks in the diffraction angles 2 theta in the X-ray powder diffraction spectrum; the amoxicillin sodium solid is added into a good solvent at 20-30 DEG C, the axlocillin sodium is completely dissolved by stirring, and the concentration of the solution is 0.2-0.3 g / ml, the system temperature is reduced to 0-15 DEG C, a poor solvent is added, crystals are crystallised out, and stirring is continued for 2-10 hours, the crystal pulp is subjected to filtration, washing and drying to obtain the amoxicillin sodium crystal form product. The crystal form crystal is large in particle size and good in fluidity, and the decomposition temperature is 217 + / -1 DEG C, the solubility of the product is large, the solubility of the product is improved, and the absorption and utilization of the drug are facilitated.

The invention relates to a crystal form of azlocillin sodium and a crystallization preparing method thereof. An X-ray powder diffraction spectrum is used for carrying out representation at the diffraction angle 2<theta> degrees and the characteristic peak of TGA; under the temperature ranging from 25 DEG C to 35 DEG C, an azlocillin sodium solid is added into a good solvent, stirring is carried out to enable azlocillin sodium to be dissolved completely, and a solution with the concentration being 0.05-0.2 g / mL is prepared; under the condition of applying the ultrasonic wave effect, a poor solvent is added into the solution, and a crystal is separated out, wherein the use amount of the poor solvent is 3-5 times of the volume of the good solvent; then temperature is lowered to 0 DEG C-10 DEG C, and stirring continues to be carried out for 1-3 h; crystal slurry is filtered, washed and dried to obtain an azlocillin sodium crystal-form product. The decomposition temperature of the novel crystal form is 229+ / -1 DEG C, and it shows that the stability of the product is improved. Meanwhile, the crystal-form product is of a sphere shape, is large in grain size, has higher bulk density and better mobility, and is more beneficial for the follow-up formulation process, product storage and use.

The invention belongs to the technical field of medicines, and particularly relates to an azlocillin sodium compound. The structural formula of the azlocillin sodium compound is defined in the specification, and the X-ray powder diffraction spectrogram of the azlocillin sodium compound, which is obtained by measurement by using Cu-K alpha ray, is shown in the figure 1. The invention further provides a preparation method of the azlocillin sodium compound, a medicine composition containing the azlocillin sodium compound, and a preparation method of the medicine composition. The dosage forms of the azlocillin sodium compound are sterile powder injection and freeze-dried powder injection. The azlocillin sodium compound provided by the invention almost does not absorb moisture, is easy to store and has good storage stability and low impurity content; and therefore, medication safety is greatly improved.