Application of microorganism-derived plasmalogen to treatment of colon cancer

A plasmalogen, microbial source technology, applied in the field of biomedicine and microorganisms, can solve the problems of colon cancer treatment limitations and other problems, achieve the effect of reducing the number and volume, and inhibiting proliferation

Active Publication Date: 2021-08-13
JIANGNAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a method for improving colon cancer, which solves the problem of treatment limitations of colon cancer

Method used

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  • Application of microorganism-derived plasmalogen to treatment of colon cancer
  • Application of microorganism-derived plasmalogen to treatment of colon cancer
  • Application of microorganism-derived plasmalogen to treatment of colon cancer

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Experimental program
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Embodiment 1

[0024] 1. Obtaining microbial source plasmalogens

[0025] The strains of microbial source plasmalogens are anaerobic microorganisms, including Lactobacillaceae, Bifidobacterium, Clostridium butyricum, Peptostreptococcus Kluyver and van Niel, Veillonella (Veillonella) and other plasmalogen-positive microorganisms (ie, microorganisms containing plasmalogen), a plasmalogen-positive microbial strain or a combination of microbial strains of plasmalogen-positive microorganisms;

[0026] 1) Culture Bifidobacterium longum (Bifidobacterium longum) and Clostridium butyricum (Clostridium butyricum) respectively, the inoculum amount is 0.1%, and culture them in MRS liquid medium for 24 hours, respectively collect Bifidobacterium longum and Clostridium butyricum The culture solution was centrifuged at 3500rpm / min and the cells were collected. The plasmalogen composition of the two microorganisms is shown in Table 1. The composition detection method adopts liquid chromatography-mass spect...

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Abstract

The invention discloses application of microorganism-derived plasmalogen to treatment of colon cancer, and belongs to the technical field of biological medicines and microorganisms, and aims to provide a method for improving the colon cancer. The invention provides application of microorganism-derived plasmalogen to preparation of a drug for treating colon cancer. The microorganism-derived plasmalogen is extracted from any one or more of anaerobic microbes such as lactobacillaceae, bifidobacterium, clostridium butyricum and peptostreptococcus kluyver and van niel in a mixed manner. The microorganism-derived plasmalogen can reduce the expression of colon cancer related cytokines from a molecular level, and inhibit proliferation of colon cancer cells and reduce the number and volume of colonic adenomas of a colon cancer patient, can be used as an effective nutrition strategy for preventing and treating the colon cancer, and provides a theoretical support for efficient utilization of the enteric microorganism-derived plasmalogen.

Description

technical field [0001] The invention relates to the application of a microbial source plasmalogen in the treatment of colon cancer, and belongs to the technical field of biomedicine and microorganisms. Background technique [0002] Colon cancer is an inherited disease that targets the tissues of the colon and is caused by mutations in specific genes that can give one cell an advantage over its neighbors. With enough mutations in certain genes, cells can become cancerous and divide uncontrollably, forming tumors. Colon cancer is now the second most common cause of cancer death in the world. Risk factors include: Family history. Inflammatory bowel disease, diabetes, low fiber and high fat diet, radiation therapy for cancer, hereditary colon cancer syndrome, etc. At present, its prevention and improvement methods are still limited, and it is the current research and industry trend to use less toxic and more natural methods, combined with current treatment methods, to treat c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/685A23K20/158A23L33/115A61P35/00
CPCA61K31/685A61P35/00A23L33/115A23K20/158A23V2002/00A23V2200/308A23V2250/18A23L33/12A61K35/742A61K35/744A61K35/745C12P7/6481C12N1/20
Inventor 刘元法刘炎峻徐勇将
Owner JIANGNAN UNIV
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