Sulphone compounds and methods of making and using same
By developing compounds that can inhibit MetAP2 activity, we have solved the problem of limited effectiveness of existing obesity treatments and achieved effective weight loss and improved treatment effects for obesity-related diseases.
CN102639494AInactive Publication Date: 2012-08-15ZAFGEN INC
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Patent Information
- Application Number
- CN201080055213.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2009-10-09
- Filing Date
- 2010-10-08
- Publication Date
- 2012-08-15
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
Technical Problem
Existing obesity treatments have limited effects and severe side effects, and there is a lack of effective drugs to regulate MetAP2 enzymatic activity to treat obesity-related diseases.
Method used
A compound has been developed for the treatment of obesity, type 2 diabetes and other obesity-related pathologies by inhibiting the enzymatic activity of MetAP2, including pharmaceutical compositions that improve insulin resistance, reduce hepatic lipids and cardiac burden.
Benefits of technology
Effectively reduce weight, increase fat oxidation, reduce food consumption, improve the treatment of obesity and related diseases, and reduce side effects.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention provides sulphone compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various sulphone compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
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