Method for synthetizing Tebipenem intermediate
Through the innovative chemical reaction of ethanolamine and allylamine, the synthesis process of tebipenem intermediate is simplified, solving the problems of complex and low yield of existing methods, achieving high yield and adaptability to industrial production.
Patent Information
- Application Number
- CN201410532384.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2014-10-11
- Publication Date
- 2016-04-13
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
The existing chemical synthesis methods of tebipenem intermediates are complex, have numerous steps, are difficult to operate, have low reaction yields, and are expensive reagents, making them unsuitable for industrial production.
Using ethanolamine and allylamine as raw materials, 1-(4,5-dihydrothiazol-2-yl) is formed through a series of innovative chemical reaction steps, including addition, cyclization, ring opening, hydrolysis and C-N coupling. Azetidine-3-thiol hydrochloride simplifies the process and improves the yield.
The process is simplified, the steps are reduced, the reaction yield is improved, the operation is simple, the reagents are cheap and easy to obtain, it is suitable for industrial production, and the yield is higher than the traditional method.