Ointment with skin whitening and repairing function

Abstract

The invention discloses an ointment with skin whitening and repairing functions. The ointment is prepared from the following raw materials in parts by weight: 20-30 parts of cooked rehmannia, 15-25 parts of astragalus, 18-22 parts of angelica, 10-20 parts of bupleurum, 15-25 parts of cyperus, 8-12 parts of citron, 15-25 parts of tuckahoe, 10-20 parts of coix seeds, 10-20 parts of labiatae, 8-15 parts of cimicifuga, 10-20 parts of cassia twig and 10-20 parts of platycodon. A preparation method and use of the ointment are also disclosed. The ointment is mainly used for replenishing qi and blood, and concurrently for soothing the liver, while strengthening the spleen and removing dampness, and can be used in combination with improving the middle qi to treat chloasma, and can more effectively solve the clinical symptoms of chloasma patients with qi and blood deficiency during pregnancy.

Description

Technical Field

[0001] The invention relates to the technical field of daily chemical products, in particular to an ointment with skin whitening and repairing functions, and specifically relates to the application of removing chloasma. Background Art

[0002] Chloasma is caused by a variety of factors, which leads to yellow-brown pigmentation spots on the face. It is not an independent disease, but a subtype of skin melanosis. Chinese medicine explains: Chloasma on the face is caused by poor liver and kidney function, which leads to qi deficiency and blood stasis, resulting in the inability to excrete toxins. Toxins in the body are deposited on the face, forming chloasma. Western medicine explains: Chloasma on the face is caused by hormone secretion disorders or obstacles in the body and a series of chain causes, such as high work and life pressure, poor sun protection, and the use of inferior cosmetics, which eventually lead to the accumulation of pigments on the face and the growth of chloasma.

[0003] Chloasma is related to the deficiency of Yin blood in the human body, especially the physiological characteristics of pregnant women, which cannot be separated from the sufficiency of Yin blood in the body. If Yin blood is insufficient, it may lead to this type of skin disease, so Chinese medicine has a theory that "women are based on blood". The main cause and pathogenesis of chloasma are related to the kidney, liver, spleen, Chong and Ren meridians of the human body. Chinese medicine will regulate the liver, spleen, kidney and Qi and blood according to the deficiency or insufficiency of these organs.

[0004] Modern medicine believes that chloasma produced during pregnancy is due to the blockage of microcirculation between tissue cells, cell dissolution and death, and increased melanin. The facial epidermis is the thinnest, with the most abundant capillaries, and is most prone to pigmentation. Pigmentation is mainly at the base of the epidermis, and the melanin granules increase significantly. More serious cases also have more melanin in the dermal melanophages. Compared with normal, melanin formation and the activity of melanin granules have different growth. Summary of the invention

[0005] The purpose of the present invention is to provide an ointment with skin whitening and repairing function and a preparation method and application thereof in view of the deficiencies of the prior art.

[0006] To achieve the above object, the technical solution adopted by the present invention is:

[0007] Disclosed is an ointment with skin whitening and repairing functions. The ointment is prepared from the following raw materials in parts by weight: 20-30 parts of cooked rehmannia, 15-25 parts of astragalus, 18-22 parts of angelica, 10-20 parts of bupleurum, 15-25 parts of cyperus, 8-12 parts of citron, 15-25 parts of tuckahoe, 10-20 parts of coix seeds, 10-20 parts of white hyacinth bean, 8-15 parts of cimicifuga, 10-20 parts of cassia twig, and 10-20 parts of platycodon.

[0008] The ointment is prepared from the following raw materials in parts by weight: 25 parts of cooked rehmannia, 20 parts of astragalus, 20 parts of angelica, 15 parts of bupleurum, 20 parts of cyperus, 10 parts of citron, 20 parts of tuckahoe, 15 parts of coix seeds, 15 parts of white labiatae, 12 parts of cimicifuga, 15 parts of cassia twig, and 15 parts of platycodon.

[0009] The ointment is prepared from the following raw materials in parts by weight: 20 parts of cooked rehmannia, 25 parts of astragalus, 18 parts of angelica, 20 parts of bupleurum, 15 parts of cyperus, 12 parts of citron, 15 parts of tuckahoe, 20 parts of coix seeds, 10 parts of white hyacinth bean, 15 parts of cimicifuga, 10 parts of cassia twig, and 20 parts of platycodon.

[0010] The ointment is prepared from the following raw materials in parts by weight: 30 parts of cooked rehmannia, 15 parts of astragalus, 22 parts of angelica, 10 parts of bupleurum, 25 parts of cyperus, 8 parts of citron, 25 parts of tuckahoe, 10 parts of coix seeds, 20 parts of white hyacinth bean, 8 parts of cimicifuga, 20 parts of cassia twig, and 10 parts of platycodon.

[0011] The ointment is prepared according to a conventional preparation method of traditional Chinese medicine.

[0012] The ointment is used in preparing cosmetics for treating chloasma.

[0013] The chloasma mentioned here refers to the chloasma produced during pregnancy, which is a symptom of qi and blood deficiency.

[0014] The ointment, the preparation method comprises the following steps:

[0015] (1) Take the raw materials: Rehmannia glutinosa, Astragalus membranaceus, Angelica sinensis, Bupleurum chinense, Cyperus rotundus, Citron, Poria cocos, Coix seeds, White Bean, Cimicifuga heracleifolia, Cinnamomum cassia twig, Platycodon grandiflorum, soak them in water for 1 hour, add 10 times the mass of water, boil for 1-2 hours, filter after boiling, and obtain a first filter residue and a first filtrate;

[0016] (2) adding 8 times the mass of water to the first filter residue, boiling for 1-2 hours, and filtering after completion to obtain a second filter residue and a second filtrate;

[0017] (3) combining the first filtrate and the second filtrate, concentrating to a density of 1.0-1.3, and standing at 2-8° C. for 40-60 hours to separate the layers, and the supernatant is the Chinese medicine extract;

[0018] (4) adding the Chinese medicine extract to the oil phase prepared from stearic acid, glyceryl monostearate, octadecyl alcohol and liquid paraffin, sterilizing and packaging to obtain the ointment.

[0019] Rehmannia glutinosa is the rhizome of Rehmannia glutinosa or Rehmannia glutinosa of the Scrophulariaceae family, which is processed, steamed and dried. It nourishes yin and replenishes blood. It is used to treat yin deficiency and blood deficiency, weakness of waist and knees, fatigue cough and bone steaming, spermatorrhea, metrorrhagia, irregular menstruation, thirst, frequent urination, deafness and blurred vision.

[0020] Astragalus is the root of Astragalus memeranaceus (Fisch.) Bge. Var. mongholicus (Bge.) Hsiao or A. membranaceus (Fisch.) Bge. of the genus Astragalus in the Leguminosae family. It has the effects of strengthening the spleen and replenishing the middle, raising yang and lifting the sunken, strengthening the body's defense system, promoting urination, and removing toxins and promoting tissue regeneration. It is mainly used to treat spleen qi deficiency syndrome, lung qi deficiency syndrome, qi deficiency and spontaneous sweating syndrome, qi and blood deficiency, sores that are difficult to heal or ulcers that are difficult to heal for a long time, etc.

[0021] Angelica sinensis is the dried root of Angelica sinensis (Oliv.) Diels, a plant of the Umbelliferae family. It is mainly produced in southeastern Gansu, with Minxian producing the most and producing the best quality, followed by Yunnan, Sichuan, Shaanxi, Hubei and other provinces, all of which are cultivated. It has the effects of nourishing blood and activating blood circulation, regulating menstruation and relieving pain, and moistening the intestines and relieving constipation. It is often used for blood deficiency and sallow complexion, dizziness and palpitations, irregular menstruation, amenorrhea and dysmenorrhea, asthenic abdominal pain, rheumatic arthralgia, injuries from falls, carbuncle, ulcers, and constipation caused by dry intestines. Wine Angelica sinensis activates blood circulation and regulates menstruation. It is used for amenorrhea and dysmenorrhea, rheumatic arthralgia, and injuries from falls.

[0022] Bupleurum is the dried root of the Umbelliferae plant Bupleurum or Angustifolia. It is dug in spring and autumn, the stems, leaves and mud are removed, and then dried. Bupleurum is a commonly used antipyretic. Also known as ground smoke, mountain vegetable, mushroom grass, and firewood, it is bitter and slightly cold in nature and enters the liver and gallbladder meridians. It has the effects of reconciling the exterior and interior, soothing the liver and raising yang. It is used for colds and fever, alternating colds and heat, malaria, liver depression and qi stagnation, chest and rib pain, rectal prolapse, uterine prolapse, and irregular menstruation.

[0023] Cyperus rotundus is the dried rhizome of Cyperus rotundus, a plant of the Cyperaceae family. It is collected in autumn, the hair is burned off, and it is placed in boiling water and boiled or steamed thoroughly before drying in the sun, or burned and then directly dried in the sun. It tastes pungent, slightly bitter, slightly sweet, and neutral. It enters the liver, spleen, and triple burner meridians. It soothes the liver and relieves depression, regulates qi and relieves fullness, regulates menstruation and relieves pain. It is used for liver depression and qi stagnation, chest and flank distension and pain, hernia pain, breast distension and pain, spleen and stomach qi stagnation, abdominal distension, distension and pain, irregular menstruation, amenorrhea and dysmenorrhea.

[0024] Buddha's hand is the dried fruit of Citrusmedica Lvar.sarcodac-tylis Swingle, a plant of the Rutaceae family. The fruit is harvested in autumn before or when it turns yellow, cut into thin slices, and dried in the sun or at low temperature. It tastes pungent, bitter, and sour, and is warm in nature. It enters the liver, spleen, stomach, and lung meridians. It soothes the liver and regulates qi, harmonizes the stomach and relieves pain, and dries dampness and resolves phlegm. It is used for liver and stomach qi stagnation, chest and flank distension and pain, fullness in the stomach, loss of appetite and vomiting, and cough with excessive phlegm.

[0025] Poria cocos is the dried sclerotium of the fungus Poria cocos (Schw.) Wolf of the Polyporaceae family. It is usually dug from July to September, and after removing the mud and sand, it is piled up to "sweate", spread out to dry on the surface, and then "sweated" again, and repeated several times until wrinkles appear and most of the internal moisture is lost, and then dried in the shade, which is called "Poria cocos pieces"; or fresh Poria cocos is cut according to different parts, dried in the shade, and respectively called "Poria cocos blocks" and "Poria cocos slices". It tastes sweet and light, and is neutral in nature. It enters the heart, lung, spleen, and kidney meridians. It can promote diuresis and eliminate dampness, strengthen the spleen, and calm the mind. It is used for edema and oliguria, phlegm and fluid, dizziness and palpitations, spleen deficiency and poor appetite, loose stools and diarrhea, restlessness, palpitations and insomnia.

[0026] Coix seeds are the dried mature kernels of Coix lacryma-jobi L. var. mayuen (Roman.) Stapf, a plant of the Gramineae family. The plants are harvested in autumn when the fruits are ripe, dried in the sun, the fruits are beaten, and dried again in the sun. The shells, yellow-brown seed coats and impurities are removed, and the kernels are collected. It tastes sweet and light, and is cool in nature. It enters the spleen, stomach, and lung meridians. It has the functions of promoting water and dampness, strengthening the spleen and stopping diarrhea, removing numbness, draining pus, and detoxifying and dispersing stagnation. It is used for edema, beriberi, dysuria, spleen deficiency diarrhea, dampness and numbness, lung abscess, intestinal abscess; warts, and cancer.

[0027] White lentil is the white seed of lentil of the legume family. Pick the mature pods around the beginning of winter, dry them, beat out the seeds, and then dry them completely. Functions and indications: invigorate the spleen and harmonize the middle, eliminate heat and dampness. Treat vomiting and diarrhea due to heat and dampness, vomiting and regurgitation due to spleen deficiency, long-term diarrhea due to poor appetite, thirst due to water retention, leucorrhea, and malnutrition in children. ① "Bie Lu": Mainly harmonize the middle and lower qi. ② "Yao Xing Lun": Mainly detoxify all plant poisons, chew raw and decoct in decoction. ③ Meng Shen: Treat cholera vomiting and diarrhea, grind it, and take it with vinegar. ④ "Rihuazi Bencao": Nourish the five internal organs. ⑤ "Bencao Tujing": Mainly promote wind and qi, leucorrhea in women, kill alcohol poisoning, and also resolve pufferfish poisoning. ⑥ "Yunnan Bencao": Treat spleen and stomach weakness, nausea and cold vomiting, long-term diarrhea, food accumulation and lumps, and malnutrition in children. ⑦ "Pinhui Jingyao": Eliminate heat and harmonize the middle. ⑧ "Compendium of Materia Medica": Stops diarrhea, relieves heat, warms the spleen and stomach, removes dampness and heat, and stops thirst. ⑨ "Hui Yue Yi Jing": When used raw, it clears heat and nourishes the stomach, and when fried, it strengthens the spleen and stops diarrhea.

[0028] Cimicifuga heracleifolia, also known as Longan root, Zhouma, and Cave Tooth root, is the rhizome of Cimicifuga datriloba, Xing'an Cimicifuga, or Cimicifuga, a plant of the Ranunculaceae family and the Cimicifuga genus. It is a perennial herb, 1 to 2 meters high. The rhizome is irregularly blocky, multi-branched, nodular, with hole-like stem scars, dark brown on the surface, and many thin fibrous roots. The stem is erect and has sparse soft hairs. The leaves are alternate, and the basal leaves and lower stem leaves are two to three pinnate compound leaves; the leaflets are long ovate or lanceolate, with coarse serrations on the edges, the leaf surface is green, the back of the leaf is gray-green, and both sides are covered with short soft hairs. Flowers are small, yellow-white, arranged in panicles up to 112.5px long, growing at the top of branches; sepals are 5, with hairy edges; stamens are 2, with 2 lobes at the tip; stamens are numerous; fruits are borne in September, fruits are densely covered with short soft hairs, oblong and slightly flat, and are best dug in autumn, sand is removed, and the fibrous roots are dried in the sun, then the fibrous roots are burned or removed, and dried for later use. Grown in grass on hillsides, forest edges, mountain roadsides, and bushes. Mainly produced in Liaoning, Jilin, Heilongjiang, Hebei, Shanxi, Shaanxi, Sichuan, Qinghai and other provinces. Pungent, sweet, slightly cold. Enters the lung, spleen, large intestine, and stomach meridians. Releases and clears rashes, clears away heat and detoxifies, and raises yang and lifts the sunken. Epidemic diseases, headaches, colds and fever, sore throats, mouth sores, macules that do not penetrate; sinking of the middle qi, chronic diarrhea and dysentery, rectal prolapse, metrorrhagia and leucorrhea in women, uterine prolapse; carbuncle, swelling, and sores.

[0029] Cassia twig belongs to the family Lauraceae, Cinnamales, and is a medium-sized tree. It is an annual with cylindrical branches, broadly ovate bud scales at the top, and alternate green leaves, oblong to nearly lanceolate. The flowers are white, about 4.5mm long. The fruits are oval, black-purple when ripe, and hairless. The flowering period is from June to August, and the fruiting period is from October to December. It is mainly produced in Guangxi, Guangdong, Yunnan, and other places. Cut the young branches in spring and summer, dry them in the sun or in the shade, and cut them into thin slices or small pieces for use. It is pungent, sweet, and warm. It enters the heart, lung, and bladder meridians. It has the effects of sweating and relieving muscles, warming and unblocking meridians, helping yang and transforming qi, and calming and descending qi. It is often used for colds caused by wind and cold, cold pain in the abdomen, amenorrhea caused by blood cold, joint pain, phlegm and fluid retention, edema, palpitations, etc.

[0030] Platycodon grandiflorus (Jacq.) A.Dc. is a plant of the Campanulaceae family. It is excavated in spring and autumn, washed, the fibrous roots are removed, the skin is peeled while fresh or not, and dried. It grows on mountain grass slopes, forest edges, or is cultivated. It is distributed in various regions of the country. It has the effects of clearing the lungs, relieving sore throat, removing phlegm, and expelling pus. It is used for cough with phlegm, chest tightness, sore throat, hoarseness, and vomiting pus due to lung abscess.

[0031] The advantages of the present invention are:

[0032] 1. According to traditional Chinese medicine theory, the causes of chloasma during pregnancy are: first, liver qi stagnation, which leads to blood stasis on the face; second, spleen and stomach weakness, qi and blood cannot nourish the face, damp heat rises on the face to form spots; third, kidney yang is insufficient, yang is dispersed, and blood stasis forms chloasma on the face. After pregnancy, the placenta secretes more androgens, so symmetrical chloasma often appears on the cheeks of pregnant women, but after giving birth, when androgen secretion returns to normal, most people's spots will naturally decrease or disappear. Traditional Chinese medicine often treats by soothing the liver and clearing away dampness and heat, but good results are not achieved. The present invention believes that chloasma is closely related to the liver, spleen, and kidney, but the main pathogenesis is that qi and blood cannot be nourished on the face, especially during pregnancy, qi and blood nourish the uterus, so other internal organs are deficient in qi and blood, which easily causes chloasma. Pregnant women seen in clinical practice often start 2-5 months after pregnancy, symmetrically occur on the face, especially in the cheeks, forehead, nose, lips and chin, etc.; skin lesions are light brown to dark brown, light black patches, varying in size, with pale complexion, dizziness, fatigue, pale lips and claws, pale tongue, and weak pulse. Women's menstruation, pregnancy, childbirth, breastfeeding, etc. often consume more blood, causing qi and blood deficiency, blood deficiency cannot be nourished, blood weakness cannot be hua flesh, qi deficiency cannot circulate blood, then blood stagnation. The present invention focuses on replenishing qi and blood, and concurrently soothes the liver to treat chloasma, while strengthening the spleen and eliminating dampness, and cooperating with improving the middle qi, which can more effectively solve the clinical symptoms of chloasma patients due to qi and blood deficiency, and has the function of whitening and repairing the skin.

[0033] 2. The present invention optimizes each raw material and its weight ratio to achieve the best clinical efficacy. Research results show that this ratio can improve the clinical symptoms of patients with qi and blood deficiency chloasma and has the function of skin whitening and repairing.

[0034] 3. The raw materials of the present invention conform to the principle of "monarch, minister, assistant and messenger" compatibility: Qi and blood nourish the uterus during pregnancy, so other organs are deficient in qi and blood, and qi and blood cannot be nourished on the face. When women are pregnant, their mood is always up and down, and they are prone to liver qi stagnation. The present invention uses Rehmannia glutinosa, Astragalus membranaceus, and Angelica sinensis to replenish qi and blood, Bupleurum chinense, Cyperus rotundus, and Citrus citron to soothe the liver, which are monarch drugs. At the same time, women experience stagnation of water and dampness in the body during pregnancy, so Poria cocos, Coix seeds, and White Lablab are used to strengthen the spleen and eliminate dampness, which are minister drugs; threatened abortion caused by deficiency of both qi and blood during pregnancy, so Cimicifuga heracleifolia, Cinnamon twig, and Platycodon grandiflorum are used to enhance the middle qi, which are assistant drugs. The present invention has a rigorous prescription, a wide range of applications, and has the functions of treating chloasma due to deficiency of qi and blood and whitening and repairing skin. DETAILED DESCRIPTION

[0035] The present invention will be further described below in conjunction with specific embodiments. It should be understood that these embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that after reading the content of the present invention, those skilled in the art can make various changes or modifications to the present invention, but these equivalent forms fall within the scope limited by the appended claims of the application equally.

[0036] Example 1

[0037] Take 25g of Rehmannia glutinosa, 20g of Astragalus, 20g of Angelica sinensis, 15g of Bupleurum, 20g of Cyperus rotundus, 10g of Citron, 20g of Poria, 15g of Coix seeds, 15g of White Lentil, 12g of Cimicifuga heracleifolia, 15g of Cinnamon twig, and 15g of Platycodon grandiflorum.

[0038] The preparation method comprises the following steps:

[0039] (1) Take the raw materials: Rehmannia glutinosa, Astragalus membranaceus, Angelica sinensis, Bupleurum chinense, Cyperus rotundus, Citron, Poria cocos, Coix seeds, White Bean, Cimicifuga heracleifolia, Cinnamomum cassia twig, Platycodon grandiflorum, soak them in water for 1 hour, add 10 times the weight of water, boil for 1 hour, filter after boiling, and obtain a first filter residue and a first filtrate;

[0040] (2) adding 8 times the mass of water to the first filter residue, boiling for 2 h, and filtering after completion to obtain a second filter residue and a second filtrate;

[0041] (3) combining the first filtrate and the second filtrate, concentrating the mixture to a density of 1.0, and standing the mixture at 8° C. for 40 h to separate the layers. The supernatant is the Chinese medicine extract;

[0042] (4) adding the Chinese medicine extract to the oil phase prepared from stearic acid, glyceryl monostearate, octadecyl alcohol and liquid paraffin, sterilizing and packaging to obtain the ointment.

[0043] Example 2

[0044] Take 20g of Rehmannia glutinosa, 25g of Astragalus, 18g of Angelica sinensis, 20g of Bupleurum, 15g of Cyperus rotundus, 12g of Citron, 15g of Poria, 20g of Coix seeds, 10g of White Lentil, 15g of Cimicifuga heracleifolia, 10g of Cinnamon twig, and 20g of Platycodon grandiflorum.

[0045] The preparation method comprises the following steps:

[0046] (1) Take the raw materials: Rehmannia glutinosa, Astragalus membranaceus, Angelica sinensis, Bupleurum chinense, Cyperus rotundus, Citron, Poria cocos, Coix seeds, White Bean, Cimicifuga heracleifolia, Cinnamomum cassia twig, Platycodon grandiflorum, soak them in water for 1 hour, add 10 times the weight of water, boil for 2 hours, filter after boiling, and obtain a first filter residue and a first filtrate;

[0047] (2) adding 8 times the mass of water to the first filter residue, boiling for 1 hour, and filtering after completion to obtain a second filter residue and a second filtrate;

[0048] (3) combining the first filtrate and the second filtrate, concentrating the mixture to a density of 1.3, and standing the mixture at 2° C. for 60 h to separate the layers. The supernatant is the Chinese medicine extract;

[0049] (4) adding the Chinese medicine extract to the oil phase prepared from stearic acid, glyceryl monostearate, octadecyl alcohol and liquid paraffin, sterilizing and packaging to obtain the ointment.

[0050] Example 3

[0051] Take 30g of Rehmannia glutinosa, 15g of Astragalus, 22g of Angelica sinensis, 10g of Bupleurum, 25g of Cyperus rotundus, 8g of Citron, 25g of Poria, 10g of Coix seeds, 20g of White Lentil, 8g of Cimicifuga heracleifolia, 20g of Cinnamomum cassia twig, and 10g of Platycodon grandiflorum.

[0052] The preparation method comprises the following steps:

[0053] (1) Take the raw materials: Rehmannia glutinosa, Astragalus membranaceus, Angelica sinensis, Bupleurum chinense, Cyperus rotundus, Citron, Poria cocos, Coix seeds, White Bean, Cimicifuga heracleifolia, Cinnamomum cassia twig, Platycodon grandiflorum, soak them in water for 1 hour, add 10 times the weight of water, boil for 2 hours, filter after boiling, and obtain a first filter residue and a first filtrate;

[0054] (2) adding 8 times the mass of water to the first filter residue, boiling for 1 hour, and filtering after completion to obtain a second filter residue and a second filtrate;

[0055] (3) combining the first filtrate and the second filtrate, concentrating to a density of 1.2, and standing at 5° C. for 50 hours to separate the layers, and the supernatant is the Chinese medicine extract;

[0056] (4) adding the Chinese medicine extract to the oil phase prepared from stearic acid, glyceryl monostearate, octadecyl alcohol and liquid paraffin, sterilizing and packaging to obtain the ointment.

[0057] Example 4

[0058] Clinical observation data sample preparation: clinical trial samples were prepared according to the above Example 1, with a specification of 10 g / vial.

[0059] General information: All 50 patients were outpatients from May 2021 to August 2022. Symptoms of chloasma during pregnancy were met, with chloasma occurring symmetrically on the face, especially on the cheeks, forehead, nose, lips and chin; the lesions were light brown to dark brown, light black patches of varying sizes, accompanied by pale complexion, dizziness, fatigue, pale lips and nails, pale tongue, and weak pulse. No infection, no allergy to this drug, no mental abnormality. Other skin diseases and allergic diseases were excluded. Those who had not used similar drugs before treatment and were not undergoing other similar drug trials.

[0060] Exclusion criteria: 1. Do not meet the diagnosis and inclusion criteria for chloasma; 2. Have concurrent infection, allergy to this drug, or mental disorder. 3. According to the researcher's judgment, have other medical histories that reduce the possibility of inclusion or complicate inclusion, such as frequent changes in work environment, which may easily lead to loss of follow-up; or are participating in other drug clinical studies.

[0061] Treatment of chloasma patients: Apply the ointment of the present invention to the face with a sterile cotton swab, twice a day, 30 minutes each time, stop using other skin care products and drugs with special therapeutic effects during the treatment, and one month is a course of treatment. Advise the patient to keep a good mood during the treatment, avoid excessive worry and overwork, and try to avoid sunlight exposure, eat less soy sauce, pickles, cigarettes, alcohol, coffee and other pigmented foods, and avoid spicy foods.

[0062] Efficacy observation: The efficacy standard refers to the "Guidelines for Clinical Research of New Chinese Medicines". Basically cured: ① The area of ​​the spots subsided by more than 90% as seen by the naked eye, the color basically disappeared, and no obvious spots were visible to the naked eye at a distance of 1 meter. ② The decline index calculated by the scoring method after treatment was ≥0.8. Significantly effective: ① The area of ​​the spots subsided by more than 60% as seen by the naked eye, and the color became significantly lighter. ② The decline index calculated by the scoring method after treatment was ≥0.5. Improved: ① The area of ​​the spots subsided by more than 30% as seen by the naked eye, and the color became lighter. ② The decline index calculated by the scoring method after treatment was ≥0.3. Ineffective: ① The area of ​​the spots subsided by less than 30% as seen by the naked eye, and the color change was not obvious. ② The decline index calculated by the scoring method after treatment was ≥0.

[0063] Calculation formula (nimodipine method): [(score before treatment-score after treatment) / score before treatment]×100%.

[0064] Treatment results: All 50 cases were re-examined immediately after one course of treatment. Results: 12 cases were cured, 17 cases were markedly effective, 18 cases were effective, 3 cases were ineffective, and the total effective rate was 96%.

[0065] Typical case 1: Zhang, female, 28 years old, was clinically diagnosed with chloasma during pregnancy. She applied the ointment of the present invention on her face with a sterile cotton swab, 4 times a day, 50 minutes each time in the morning and evening. During the treatment, she stopped using other skin care products and drugs with special therapeutic effects. After three months, the color of the chloasma faded and the patient was cured, with skin whitening and repairing function.

[0066] Typical case 2: Hong, female, 25 years old, was clinically diagnosed with chloasma during pregnancy. She applied the ointment of the present invention on her face with a sterile cotton swab, 3 times a day, 60 minutes each time in the morning and evening. During the treatment, she stopped using other skin care products and drugs with special therapeutic effects. After two months, the color of the chloasma became lighter and the patient was cured, with skin whitening and repairing function.

[0067] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. An ointment with skin whitening and repairing function, characterized in that: The ointment is prepared by adding stearic acid, monostearate glyceryl, octadecyl alcohol, liquid paraffin and water to the following raw materials in parts by weight: 20-30 parts of Rehmannia glutinosa, 15-25 parts of Astragalus, 18-22 parts of Angelica sinensis, 10-20 parts of Bupleurum, 15-25 parts of Cyperus rotundus, 8-12 parts of Citron, 15-25 parts of Poria, 10-20 parts of Coix seeds, 10-20 parts of Lablab lentil, 8-15 parts of Cimicifuga heracleifolia, 10-20 parts of Cinnamomum cassia twig and 10-20 parts of Platycodon grandiflorum. The preparation method comprises the following steps: (1) Take the raw materials: Radix Rehmanniae Preparata, Radix Astragali, Radix Angelicae Sinensis, Radix Bupleuri, Rhizoma Cyperi, Citron, Poria, Semen Coicis, Radix Hyacinthiae, Rhizoma Cimicifugae, Rhizoma Cimicifugae, and Radix Platycodonis, soak them in water for 1 hour, add 10 times the mass of water, boil for 1-2 hours, filter after boiling, and obtain the first residue and the first filtrate; (2) adding 8 times the mass of water to the first filter residue, boiling for 1-2 hours, and filtering after completion to obtain a second filter residue and a second filtrate; (3) Combine the first filtrate and the second filtrate, concentrate to a density of 1.0-1.3, and let stand at 2-8°C for 40-60 hours to separate the layers. The supernatant is the Chinese medicine extract; (4) Adding the Chinese medicine extract to the oil phase prepared from stearic acid, glyceryl monostearate, octadecyl alcohol and liquid paraffin, sterilizing, and packaging to obtain the ointment.

2. The ointment according to claim 1, characterized in that The ointment is prepared from the following raw materials in parts by weight: 25 parts of cooked rehmannia, 20 parts of astragalus, 20 parts of angelica, 15 parts of bupleurum, 20 parts of cyperus, 10 parts of citron, 20 parts of tuckahoe, 15 parts of coix seeds, 15 parts of white labiatae, 12 parts of cimicifuga, 15 parts of cassia twig, and 15 parts of platycodon.

3. The ointment according to claim 1, characterized in that The ointment is prepared from the following raw materials in parts by weight: 20 parts of cooked rehmannia, 25 parts of astragalus, 18 parts of angelica, 20 parts of bupleurum, 15 parts of cyperus, 12 parts of citron, 15 parts of tuckahoe, 20 parts of coix seeds, 10 parts of white hyacinth bean, 15 parts of cimicifuga, 10 parts of cassia twig, and 20 parts of platycodon.

4. The ointment according to claim 1, characterized in that The ointment is prepared from the following raw materials in parts by weight: 30 parts of cooked rehmannia, 15 parts of astragalus, 22 parts of angelica, 10 parts of bupleurum, 25 parts of cyperus, 8 parts of citron, 25 parts of tuckahoe, 10 parts of coix seeds, 20 parts of white hyacinth bean, 8 parts of cimicifuga, 20 parts of cassia twig, and 10 parts of platycodon.

5. Use of the ointment according to any one of claims 1 to 4 in preparing cosmetics for treating chloasma.

6. The use according to claim 5, characterized in that: Chloasma is the yellow spots that occur during pregnancy, which is a symptom of Qi and blood deficiency.