A composition with anesthetic effect and its application in preparing anesthetic drugs
By discovering that tetrahydrogenoline, alanine and dihydrocerene have anesthetic effects and using them to develop new anesthetic drugs, the problem of lack of anesthetic drug selection in the prior art has been solved, and shorter anesthetic recovery time and better anesthetic effect have been achieved.
Patent Information
- Application Number
- CN202410442879.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2024-04-12
- Publication Date
- 2025-03-14
- Estimated Expiration
- 2044-04-12
AI Technical Summary
The prior art has failed to find that compounds such as tetrahydrogenol, alanine and dihydrocerene have anesthetic effects, resulting in the lack of new anesthetic drug selection.
Through active screening, tetrahydrolin, alanine and dihydroceraminine were found to have anesthetic effects and used as active ingredients for the development of anesthetic drugs, including both singly and in combination.
New anesthetic drug selections have been achieved, and the use of these compounds alone or in combination can significantly shorten the recovery time of anesthesia and provide better anesthetic effects.
Abstract
Description
Technical Field
[0001] The present invention relates to the field of biomedical technology, and in particular to a composition with anesthetic effect and application thereof in preparing anesthetic drugs. Background Art
[0002] Anesthesia refers to the use of drugs or other methods to temporarily make the patient lose all or part of the sensation in order to achieve painless surgical treatment. Currently, commonly used anesthetics include opioids, cocaine, marijuana, synthetic anesthetics, etc. In the specific application process, anesthesiologists will choose different anesthesia plans according to the specific conditions of the patients; therefore, the development of more anesthetic drugs will help provide patients with more anesthesia options and achieve better anesthesia effects.
[0003] Tetrahydrochoerithrine, solanine, and dihydrochelerythrine are all common known compounds; however, the prior art does not report that they have anesthetic effects. Summary of the invention
[0004] In order to overcome at least one of the technical problems existing in the prior art, the present invention provides a compound having an anesthetic effect, a composition and use thereof in the preparation of an anesthetic drug.
[0005] The technical solution of the present invention is as follows:
[0006] The invention firstly provides an application of tetrahydroschistosamine in the preparation of anesthetic drugs.
[0007] The invention also provides an application of solanine in preparing anesthetic drugs.
[0008] The invention also provides an application of dihydrochelerythrine in the preparation of anesthetic drugs.
[0009] The inventors surprisingly found that three compounds, tetrahydrochondrine, solanine and dihydrochelerythrine, have anesthetic effects during the activity screening of a large number of conventional compounds. Therefore, using them as active ingredients for the development of anesthetic drugs has important application value.
[0010] The present invention also provides a composition, which comprises tetrahydrochoermine, solanine
[0011] And a combination of any two or more of dihydrochelerythrine.
[0012] Since tetrahydroschwannine, solanine and dihydrochelerythrine all have anesthetic effects individually, the composition obtained by combining any two or more components of tetrahydroschwannine, solanine and dihydrochelerythrine also has anesthetic effects.
[0013] Preferably, the composition comprises tetrahydrochoerithrine, solanine and dihydrochelerythrine.
[0014] Since tetrahydroschefflerine, solanine and dihydrochelerythrine all have anesthetic effects, the composition obtained by combining tetrahydroschefflerine, solanine and dihydrochelerythrine also has anesthetic effects.
[0015] Further preferably, the weight ratio of tetrahydroschwannine, solanine and dihydrochelerythrine in the composition is 1-10:1-10:1-10.
[0016] More preferably, the weight ratio of tetrahydroschwannine, solanine and dihydrochelerythrine in the composition is 2-4:4-6:1-3.
[0017] Most preferably, the weight ratio of tetrahydroschefflerine, solanine and dihydrochelerythrine in the composition is 3:5:2.
[0018] The inventors surprisingly found in further research that the composition obtained by combining tetrahydroschwansteine, solanine and dihydrochelerythrine has a much shorter anesthesia recovery time than tetrahydroschwansteine, solanine or dihydrochelerythrine alone. This may be because the combination of tetrahydroschwansteine, solanine and dihydrochelerythrine can synergistically shorten the anesthesia recovery time.
[0019] The present invention also provides an application of the above composition in preparing anesthetic drugs.
[0020] Beneficial effects: The present invention discovers for the first time that the known compounds tetrahydroschefflerine, solanine, dihydrochelerythrine and their compositions have anesthetic effects; and provides a new use of the known compounds tetrahydroschefflerine, solanine, dihydrochelerythrine and their compositions in the preparation of anesthetic drugs.
[0021] Since the known compounds tetrahydrochoerithrine, solanine, dihydrochelerythrine and their combinations all have anesthetic effects, using them as active ingredients in the preparation of anesthetic drugs has important application value. DETAILED DESCRIPTION
[0022] The present invention is further explained below in conjunction with specific examples, but the examples do not limit the present invention in any form.
[0023] Experimental Example 1
[0024] Male SD rats weighing 250±25g were selected and randomly divided into 7 experimental groups, with 12 rats in each group. The drugs to be tested were added to normal saline to prepare a normal saline injection solution with a drug mass percentage of 2%. Then, the rats in each group were injected with tail vein at a rate of 0.1ml / s. The injection was stopped after 1 hour of continuous administration. The onset time of anesthesia and the recovery time of anesthesia after stopping the administration were recorded. The time from the start of drug injection to the disappearance of the rat's front paw righting reflex was recorded as the onset time of anesthesia, and the time from the cessation of administration to the complete recovery of the rat's front paw righting reflex was recorded as the recovery time of anesthesia.
[0025] The drug to be tested in experimental group 1 is tetrahydrocannabinol.
[0026] The drug to be tested in experimental group 2 was solanine.
[0027] The drug to be tested in experimental group 3 is dihydrochelerythrine.
[0028] The drug to be tested in Experimental Group 4 is a composition consisting of tetrahydrochoerithrine, solanine and dihydrochelerythrine in a weight ratio of 3:5:2.
[0029] The drug to be tested in Experimental Group 5 is a composition consisting of tetrahydrochoermine and solanine in a weight ratio of 3:5.
[0030] The drug to be tested in Experimental Group 6 is a composition consisting of tetrahydrochloasmaine and dihydrochelerythrine in a weight ratio of 3:2.
[0031] The drug to be tested in Experimental Group 7 is a composition consisting of solanine and dihydrochelerythrine in a weight ratio of 5:2.
[0032] Table 1. Anesthesia experimental effects of the compounds or compositions of the present invention
[0033] It can be seen from the experimental data in Table 1 that the anesthetic onset time of experimental groups 1 to 7 is less than 1 minute; this shows that tetrahydrochoerithrine, solanine, dihydrochelerythrine and their combination all have anesthetic effects.
[0034] It can also be seen from the experimental data in Table 1 that although the anesthesia onset time of experimental groups 1 to 7 is less than 1 minute, the difference in anesthesia recovery time of each group is huge; among them, the anesthesia recovery time of experimental group 4 is much shorter than that of experimental groups 1 to 3. This shows that the composition obtained by combining tetrahydroschwansteine, solanine and dihydrochelerythrine has a much shorter anesthesia recovery time than that of tetrahydroschwansteine, solanine or dihydrochelerythrine alone, and has a shorter anesthesia recovery time. The combination of tetrahydroschwansteine, solanine and dihydrochelerythrine can produce a synergistic effect of shortening the anesthesia recovery time.
[0035] It can also be seen from the experimental data in Table 1 that the anesthesia recovery time of experimental groups 5 to 7 was not significantly reduced compared with that of experimental groups 1 to 3; and its anesthesia recovery time was also significantly higher than that of experimental group 4. This shows that only the combination of tetrahydrodwarfine, solanine and dihydrochelerythrine can produce a composition with a significantly shorter anesthesia recovery time than that of individual tetrahydrodwarfine, solanine or dihydrochelerythrine; only the combination of tetrahydrodwarfine, solanine and dihydrochelerythrine can produce a significant synergistic effect of shortening the anesthesia recovery time; and the combination of any two of tetrahydrodwarfine, solanine and dihydrochelerythrine can not produce a composition with a significantly shorter anesthesia recovery time than that of individual tetrahydrodwarfine, solanine or dihydrochelerythrine; and the combination of any two of tetrahydrodwarfine, solanine and dihydrochelerythrine cannot produce a synergistic effect of shortening the anesthesia recovery time.
[0036] Example 1 Preparation of composition
[0037] The composition is obtained by mixing tetrahydrochoerithrine, solanine and dihydrochelerythrine in a weight ratio of 3:5:2 evenly.
[0038] Example 2 Preparation of composition
[0039] The composition is obtained by mixing tetrahydrochoermine and solanine in a weight ratio of 3:5 evenly.
[0040] Example 3 Preparation of composition
[0041] The composition is obtained by mixing tetrahydrochoerithrine and dihydrochelerythrine in a weight ratio of 3:2 evenly.
[0042] Example 4 Preparation of composition
[0043] The composition is obtained by mixing solanine and dihydrochelerythrine in a weight ratio of 5:2 evenly.
[0044] What is disclosed above is only a preferred embodiment of the present invention, which certainly cannot be used to limit the scope of rights of the present invention. A person skilled in the art can understand that all or part of the processes of the above embodiments and equivalent changes made according to the claims of the present invention still fall within the scope of the invention.
Claims
1. Application of tetrahydrocannabinol in the preparation of anesthetic drugs.
2. Application of solanine in the preparation of anesthetic drugs.
3. Application of dihydrochelerythrine in the preparation of anesthetic drugs.
4. A composition, characterized in that The composition comprises a combination of any two or more of tetrahydrochoerithrine, solanine and dihydrochelerythrine.
5. The composition according to claim 4, characterized in that The composition comprises tetrahydrochoerithrine, solanine and dihydrochelerythrine.
6. The composition according to claim 5, characterized in that The weight ratio of tetrahydrochoerithrine, solanine and dihydrochelerythrine in the composition is 1-10:1-10:1-10.
7. The composition according to claim 6, characterized in that The weight ratio of tetrahydrochoerithrine, solanine and dihydrochelerythrine in the composition is 2-4:4-6:1-3.
8. Use of the composition according to any one of claims 4 to 7 in the preparation of anesthetic drugs.
Citation Information
Patent Citations
New application of 8-methoxyl-dihydro chelerythrine for preparing drug for treating burn and scald inflammation
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Nitrosated and nitrosylated alpha -adrenergic receptor antagonist compounds, compositions and their uses
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