A pharmaceutical composition for treating cirrhotic ascites and a preparation method and application thereof

By preparing an appropriate dosage form through water extraction and enzymatic hydrolysis of medicinal compositions such as Anemarrhena asphodeloides, the problem of inconvenient decoction in traditional Chinese medicine treatment of ascites due to liver cirrhosis has been solved. Combined with Western medicine methods, significant therapeutic effects and ease of use have been achieved, reducing the economic burden on patients.

CN118416159BActive Publication Date: 2025-11-28THE FIRST AFFILIATED HOSPITAL OF GUIZHOU UNIV OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Application Number
CN202410548093.5
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-05-06
Publication Date
2025-11-28
Estimated Expiration
2044-05-06

AI Technical Summary

Technical Problem

Current Western medicine treatments for ascites due to cirrhosis have unsatisfactory long-term effects and significant adverse reactions, while traditional Chinese medicine treatments present inconveniences in terms of decoction, carrying, and storage during long-term use.

Method used

The drug composition consists of six medicinal materials, including Anemarrhena asphodeloides, Dioscorea nipponica, Gynostemma pentaphyllum, Dioscorea opposita, Bidens pilosa, and Achyranthes bidentata. It is prepared into solid or liquid preparations through water extraction and enzymatic extraction. Combined with conventional Western medicine symptomatic treatment, it is made into granules, capsules, tablets, pills, mixtures or syrups for easy use by patients.

Benefits of technology

It significantly improves patients' clinical symptoms and enhances their quality of life, with an overall effective rate of 83.3%. The extraction rate of effective components is greatly improved, and it is low in cost, easy to use, highly safe, and reduces adverse reactions.

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Abstract

The present application relates to the technical field of medicine, in particular to a kind of drug composition for treating cirrhosis ascites and its preparation method and application.The drug composition is composed of Radix Dipsaci, Radix Ilicis Rotundae, Peristrophe roxburghiana, Radix Potentillae Chinensis, Bidens pilosa and Eupatorium fortunei;The preparation method is to weigh Radix Dipsaci, Radix Ilicis Rotundae, Peristrophe roxburghiana, Radix Potentillae Chinensis, Bidens pilosa and Eupatorium fortunei according to the prescription amount, extract by heating with water;After water extraction, the residue is added with water and cellulase, and then extracted under certain conditions;After boiling, filter to obtain enzymatic extract;Combine the water extract and enzymatic extract, and concentrate to thick paste;Add appropriate amount of excipients to the thick paste for batching, and then prepare into corresponding dosage form to obtain the product.The drug has the effects of clearing heat and resolving toxins, soothing liver and gallbladder, dispelling wind and relieving pain, and is used for treating damp-heat jaundice, abdominal pain and diarrhea, etc.The drug composition is prepared into appropriate dosage form by modern pharmaceutical preparation technology, and the effect is more significant and faster.
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