Traditional Chinese medicine compound composition for treating functional dyspepsia and preparation method and application thereof

Abstract

The invention discloses a traditional Chinese medicine compound composition for treating functional dyspepsia and a preparation method and application thereof. The traditional Chinese medicine compound composition is prepared from 5-20 parts of gordon euryale seeds, 6-12 parts of Chinese yams, 10-30 parts of astragalus membranaceus, 10-30 parts of roasted rhizoma atractylodis macrocephalae, 10-20 parts of smoked plums, 3-15 parts of pericarpium citri reticulatae viride, 10-40 parts of malt, 6-12 parts of roasted endothelium corneum gigeriae galli, 10-20 parts of honey-fried licorice roots and the like. The traditional Chinese medicine composition is prepared according to the theory of treatment based on syndrome differentiation, has the functions of strengthening the spleen and stomach, promotes digestion and absorption, and has an exact treatment effect on related symptoms caused by dyspepsia. Most medicinal materials are medicinal and edible, have small toxic and side effects and are safe and reliable to take.

Description

Technical Field

[0001] The invention relates to a Chinese medicinal compound, in particular to a Chinese medicinal compound composition for treating functional dyspepsia and a preparation method and application thereof. Background Art

[0002] Dyspepsia is a functional disease that excludes organic gastrointestinal lesions through biochemistry or imaging. It is divided into postprandial discomfort syndrome and upper abdominal pain syndrome. Most of them are characterized by early satiety, postprandial fullness, loss of appetite, and belching. Western medicine may cause drug dependence and some special side effects when treating functional dyspepsia. Traditional Chinese medicine can not only reduce the occurrence of adverse reactions, but also effectively relieve symptoms and improve the quality of life of patients, showing its unique characteristics and advantages.

[0003] Therefore, it is necessary to develop a safe and effective Chinese medicine composition under the guidance of traditional Chinese medicine theory. Summary of the invention

[0004] Purpose of the invention: The purpose of the present invention is to solve the deficiencies of the prior art and to provide a Chinese medicine compound composition with a scientific and reasonable ratio and significant therapeutic effect on functional dyspepsia, as well as a preparation method and application thereof.

[0005] Technical solution: In order to achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0006] A Chinese medicinal compound composition for treating functional dyspepsia comprises the following raw materials in parts by weight: 5-20 parts of Euryale ferox, 6-12 parts of Chinese yam, 10-30 parts of Astragalus, 10-30 parts of stir-fried Atractylodes macrocephala, 10-20 parts of Prunus mume, 3-15 parts of Citrus aurantium, 10-40 parts of malt, 6-12 parts of stir-fried chicken gizzard lining, and 10-20 parts of roasted Licorice root.

[0007] As a preferred embodiment, the above-mentioned Chinese medicine compound composition for treating functional dyspepsia is prepared from the following raw materials in parts by weight:

[0008] 10-15 parts of Euryale ferox, 6-10 parts of yam, 10-15 parts of astragalus, 10-15 parts of stir-fried Atractylodes macrocephala, 6-15 parts of black plum, 5-15 parts of green tangerine peel, 30-40 parts of malt, 6-10 parts of stir-fried chicken gizzard lining, 6-10 parts of stir-fried Citrus aurantium, 6-8 parts of Magnolia officinalis, 1-2 parts of hawthorn, and 3-4 parts of roasted licorice.

[0009] As a preferred embodiment, the above-mentioned Chinese medicine compound composition for treating functional dyspepsia is characterized in that it is made of the following raw materials in parts by weight:

[0010] 10 parts of Euryale ferox, 6 parts of Chinese yam, 10 parts of Astragalus, 10 parts of stir-fried Atractylodes macrocephala, 12 parts of Prunus mume, 15 parts of Citrus aurantium, 30 parts of malt, 10 parts of chicken gizzard lining, 6 parts of stir-fried Citrus aurantium, 6 parts of Magnolia officinalis, 2 parts of Hawthorn, 10 parts of roasted Licorice root.

[0011] The present invention can prepare the extract of the Chinese medicine compound composition and a pharmaceutically acceptable carrier into a medicine in the form of a mixture, an ointment, an oral liquid, a granule, a capsule, a tablet, a powder injection, a dripping pill or an injection liquid;

[0012] A method for preparing a drug for treating functional dyspepsia comprises the following steps:

[0013] Take Euryale ferox, yam, astragalus, stir-fried Atractylodes macrocephala, ebony, green peel, malt, chicken gizzard lining, stir-fried Citrus aurantium, Magnolia officinalis, hawthorn, and roasted Licorice root according to the weight proportions described in any one of claims 1 to 3, add 8 to 20 times the weight of the medicinal materials in water and boil or reflux with ethanol or continuously reflux and extract for 1 to 3 times, each time for 0.5 to 1.5 hours, combine the extracts, concentrate to obtain an extract, and set aside.

[0014] (2) The extract obtained in step (1) is prepared with a pharmaceutically acceptable carrier into a drug in the form of a mixture, ointment, oral liquid, granule, capsule, tablet, powder injection, pill or injection liquid; when the extracts of the raw materials of the Chinese medicine compound provided by the present invention are made into an oral liquid, the extracts of the raw materials are dissolved in distilled water, filtered, and the pH value is adjusted to prepare an oral liquid.

[0015] When the extracts of the raw materials of the traditional Chinese medicine compound provided by the present invention are made into tablets, the extracts of the raw materials and lactose or corn starch are evenly mixed, granulated, and then compressed into tablets.

[0016] When the extract of the traditional Chinese medicine compound provided by the invention is made into capsules, the extracts of various raw materials and the carrier lactose or corn starch are evenly mixed, granulated, and then filled into capsules to make capsules.

[0017] When the extracts of various raw materials of the traditional Chinese medicine compound provided by the invention are made into granules, the extracts of various raw materials and diluent lactose or corn starch are evenly mixed, granulated, and dried to make granules.

[0018] When the extracts of various raw materials of the traditional Chinese medicine compound provided by the invention are made into powder injection, the extracts of various raw materials are freeze-dried and sterilized to make the powder injection.

[0019] Beneficial effects: The Chinese medicine compound is screened according to the theory of traditional Chinese medicine, and the proportion of each component is scientific and reasonable. Animal experiments show that the Chinese medicine compound of the present invention can effectively improve the physical conditions of rats with functional dyspepsia, such as eating, stool frequency and shape; it can improve the gastric emptying rate of rats with dyspepsia, regulate the gastrointestinal motility of rats, and thus play a definite therapeutic role on the related symptoms caused by dyspepsia. Moreover, most of the medicinal materials can be used as both medicine and food, with little toxic and side effects, and the medication is safe and reliable. DETAILED DESCRIPTION

[0020] The present invention is further explained below in conjunction with specific examples. It should be understood that these examples are only used to illustrate the present invention and are not used to limit the scope of the present invention. After reading the present invention, various equivalent modifications of the present invention by those skilled in the art all fall within the scope defined by the claims attached to this application.

[0021] Example 1

[0022] 1. A Chinese medicinal compound composition for treating functional dyspepsia, which is made of the following raw materials by weight: 15 parts of Euryale ferox, 10 parts of yam, 15 parts of astragalus, 15 parts of stir-fried Atractylodes macrocephala, 15 parts of black plum, 15 parts of green peel, 40 parts of malt, 10 parts of stir-fried chicken gizzard lining, 10 parts of stir-fried Citrus aurantium, 8 parts of Magnolia officinalis, 2 parts of hawthorn, and 4 parts of roasted liquorice.

[0023] 2. The method for preparing the Chinese medicine compound composition for treating functional dyspepsia of the present invention comprises the following steps:

[0024] (1) Take 15 parts of Euryale ferox, 10 parts of Chinese yam, 15 parts of Astragalus, 15 parts of stir-fried Atractylodes macrocephala, 15 parts of Prunus mume, 15 parts of Citrus aurantium, 40 parts of malt, 10 parts of stir-fried Chicken gizzard lining, 10 parts of stir-fried Citrus aurantium, 8 parts of Magnolia officinalis, 2 parts of Crataegus pinnatifida, and 4 parts of roasted Licorice root by weight, add 12 times the weight of the medicinal materials of water, decoct and extract for 3 times, the first time for 1 hour, the second time for 0.5 hours, combine the extracts, concentrate to obtain an extract, and set aside;

[0025] (2) Take the extract obtained in step (1), add the diluent lactose, mix evenly, granulate, dry, and prepare granules.

[0026] Example 2

[0027] 1. A Chinese medicinal compound composition for treating functional dyspepsia, which is made of the following raw materials by weight: 10 parts of Euryale ferox, 6 parts of yam, 10 parts of astragalus, 10 parts of stir-fried Atractylodes macrocephala, 6 parts of black plum, 5 parts of green peel, 30 parts of malt, 6 parts of stir-fried chicken gizzard lining, 6 parts of stir-fried Citrus aurantium, 6 parts of Magnolia officinalis, 1 part of hawthorn, and 3 parts of roasted liquorice.

[0028] 2. The method for preparing the functional dyspepsia Chinese medicine compound composition of the present invention comprises the following steps:

[0029] (1) Take 6g of Euryale ferox, 10g of Chinese yam, 15g of Radix Astragali, 15g of stir-fried Atractylodes macrocephala, 6g of Prunus mume, 5g of Citrus aurantium, 6g of Malt, 3g of stir-fried Gallus gallus, 6g of Citron, 10g of stir-fried Citrus aurantium, 10g of Magnolia officinalis flower, 2g of Crataegus pinnatifida, and 5g of Radix Glycyrrhizae uralensis by weight. Add 12 times the weight of the medicinal materials and boil and extract twice, each time for 1 hour, combine the extracts, concentrate to obtain an extract, and set aside;

[0030] (2) The extract obtained in step (1) is mixed evenly with carrier corn starch, granulated, and then filled into capsules to prepare capsules.

[0031] Example 3

[0032] 1. A Chinese medicinal compound composition for treating functional dyspepsia, which is made of the following raw materials by weight: 10 parts of Euryale ferox, 6 parts of yam, 10 parts of astragalus, 10 parts of stir-fried Atractylodes macrocephala, 12 parts of black plum, 15 parts of green peel, 30 parts of malt, 10 parts of chicken gizzard lining, 6 parts of stir-fried Citrus aurantium, 6 parts of Magnolia officinalis, 2 parts of hawthorn, and 10 parts of roasted liquorice.

[0033] 2. The method for preparing the Chinese medicine compound composition for treating functional dyspepsia of the present invention comprises the following steps:

[0034] 3. (1) Take 10 parts of Euryale ferox, 6 parts of Chinese yam, 10 parts of Astragalus, 10 parts of stir-fried Atractylodes macrocephala, 12 parts of Prunus mume, 15 parts of Citrus aurantium, 30 parts of malt, 10 parts of Gallus galli, 6 parts of stir-fried Citrus aurantium, 6 parts of Magnolia officinalis, 2 parts of Crataegus pinnatifida, and 10 parts of roasted Licorice root by weight. Add 10 times the weight of the medicinal materials in water and boil for 3 times, each time for 1 hour, combine the extracts, concentrate to obtain an extract, and set aside;

[0035] (2) Take the extract obtained in step (1), add diluent lactose and lubricant magnesium stearate, mix well, granulate, and then press into tablets.

[0036] The extract of the Chinese medicinal composition of Example 1 of the present invention was added to rat feed at 5%, and it was found that the rats' food intake increased by about 21% and the number of bowel movements increased compared with the rat group without the Chinese medicinal composition extract. After one week, the weight of the rats added with the Chinese medicinal composition extract increased by 8.5% on average compared with the control group. This shows that the Chinese medicinal composition of the present invention has a good effect of assisting the treatment of indigestion.

[0037] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicinal compound composition for treating functional dyspepsia, characterized in that: The invention comprises the following raw materials in parts by weight: 5-20 parts of Euryale ferox, 6-12 parts of Chinese yam, 10-30 parts of Radix Astragali, 10-30 parts of stir-fried Atractylodes macrocephala, 10-20 parts of Prunus mume, 3-15 parts of Citrus aurantium, 10-40 parts of malt, 6-12 parts of stir-fried chicken gizzard lining and 10-20 parts of roasted Licorice root.

2. The Chinese medicinal compound composition for treating functional dyspepsia according to claim 1, characterized in that: The invention is prepared from the following raw materials in parts by weight: 10-15 parts of gorgon fruit, 6-10 parts of yam, 10-15 parts of astragalus, 10-15 parts of stir-fried atractylodes, 6-15 parts of ebony, 5-15 parts of green peel, 30-40 parts of malt, 6-10 parts of stir-fried chicken gizzard lining, 6-10 parts of stir-fried immature bitter orange, 6-8 parts of magnolia bark, 1-2 parts of hawthorn and 3-4 parts of roasted liquorice.

3. The Chinese medicinal compound composition for treating functional dyspepsia according to claim 2, characterized in that: The medicine is prepared from the following raw materials in parts by weight: 10 parts of Euryale ferox, 6 parts of yam, 10 parts of astragalus, 10 parts of stir-fried Atractylodes macrocephala, 12 parts of black plum, 15 parts of green peel, 30 parts of malt, 10 parts of chicken gizzard lining, 6 parts of stir-fried Citrus aurantium, 6 parts of Magnolia officinalis, 2 parts of hawthorn and 10 parts of roasted liquorice.

4. A Chinese medicinal compound composition for treating functional dyspepsia, characterized in that: The extract of the Chinese medicine compound composition according to any one of claims 1 to 3 and a pharmaceutically acceptable carrier are prepared into a medicine in the form of a mixture, ointment, oral liquid, granule, capsule, tablet, powder injection, pill or injection solution.

5. The method for preparing the drug for treating functional dyspepsia according to claim 4, characterized in that: The following steps are involved: (1) Take Euryale ferox, Chinese yam, Astragalus membranaceus, stir-fried Atractylodes macrocephala, Prunus mume, Citrus aurantium, malt, chicken gizzard lining, stir-fried Citrus aurantium, Magnolia officinalis, Crataegus pinnatifida, and Radix Glycyrrhizae according to the weight proportions of any one of claims 1 to 3, add 8 to 20 times the weight of the medicinal materials in water and boil or reflux extract with ethanol for 1 to 3 times, each time for 0.5 to 1.5 hours, combine the extracts, concentrate to obtain an extract, and set aside.

6. (2) The extract obtained in step (1) is mixed with a pharmaceutically acceptable carrier to prepare a drug in the form of a mixture, ointment, oral solution, granules, capsule, tablet, powder injection, pill or injection solution; Use of the Chinese medicine compound composition according to any one of claims 1 to 3 in the preparation of a drug for treating functional dyspepsia.