A synthesis process of 25-hydroxycholesterol

By using phytosterol as raw material in the 25-hydroxycholesterol preparation process, combining ozonation, extension of side chains, reduction and recrystallization, and by precise control of reaction conditions and the use of continuous flow technology, the problems of multiple by-product generation, complex steps and environmental pollution in the existing technology are solved, and an efficient, economical and environmentally friendly 25-hydroxycholesterol preparation process is achieved.

CN119775336APending Publication Date: 2025-04-08YAOPU SHANGHAI PHARMA TECH CO LTD
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Patent Information

Application Number
CN202411991219.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-31
Publication Date
2025-04-08

AI Technical Summary

Technical Problem

The existing 25-hydroxycholesterol preparation technology has problems such as many by-product generation, complex steps, harsh operating conditions and possible pollution to the environment, making it difficult to meet the needs of efficient, economical and environmentally friendly industrial applications.

Method used

25-hydroxycholesterol is prepared by using phytosterol as raw material by ozonation, extension of side chains, reduction and recrystallization. By precisely controlling the reaction conditions, using continuous flow technology and nitrogen replacement, the reaction selectivity is improved, the generation of by-products is reduced, and the product purity is improved through multiple recrystallization.

Benefits of technology

It significantly improves the yield and purity of 25-hydroxycholesterol, simplifies the operation process, reduces the generation of by-products, improves the economic and environmental friendliness of the process, and is suitable for industrial scale production.

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Abstract

The present invention relates to a synthesis process of 25-hydroxycholesterol, and belongs to the technical field of drug preparation. The present invention uses phytosterol as a raw material, and prepares the target product 25-hydroxycholesterol by steps such as ozonation, side chain extension, reduction and recrystallization. During the reaction process, the reaction conditions are precisely controlled to improve the selectivity of the reaction and reduce by-products; the efficient use of ozone is achieved by continuous flow technology, while the by-product generation of peroxide is reduced; the design of combining nitrogen replacement and sodium borohydride reduction is used to avoid excessive oxidation and by-product generation; and the yield and purity of the product are significantly improved by multiple recrystallizations and post-treatments.
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