A monoclonal antibody against rabies virus N protein, a detection reagent and its application
By screening high-affinity monoclonal antibodies through genetic engineering and hybridoma cell technology, the problems of insufficient specificity and sensitivity in rabies virus detection in existing technologies have been solved, and efficient rabies virus detection has been achieved.
CN120818048BActive Publication Date: 2025-12-02北京纳百生物科技有限公司
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Patent Information
- Application Number
- CN202511326776.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2025-09-17
- Publication Date
- 2025-12-02
- Estimated Expiration
- 2045-09-17
AI Technical Summary
Technical Problem
Existing technologies struggle to provide highly specific and sensitive monoclonal antibodies for rapid rabies virus detection, resulting in poor detection outcomes.
Method used
Using genetic engineering and hybridoma cell technology, a monoclonal antibody with high affinity and detection sensitivity for the rabies virus N protein was screened and prepared into a detection reagent, including the monoclonal antibody, nucleic acid molecule, expression vector, host cell, and test strip.
Benefits of technology
This method achieves highly specific and sensitive detection of rabies virus N protein, and is suitable for the development of colloidal gold test strips and fluorescent immunoassay strips, thus improving the accuracy and efficiency of detection.
✦ Generated by Eureka AI based on patent content.
Abstract
This invention discloses a monoclonal antibody against rabies virus N protein, a detection reagent, and their applications. The monoclonal antibody against rabies virus N protein includes a heavy chain variable region and a light chain variable region; the amino acid sequence of the heavy chain variable region is shown in SEQ ID No. 1; the amino acid sequence of the light chain variable region is shown in SEQ ID No. 2. This invention provides a monoclonal antibody with high affinity and detection sensitivity against rabies virus N protein, laying the foundation for the research and development and promotion of colloidal gold test strips and fluorescent immunoassay strips.
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