Photoresponse microneedle system for promoting repair of diabetes infected wound and preparation method of photoresponse microneedle system

By preparing composite microneedles with photocatalytic function, and utilizing the photocatalytic reaction generated by nanoparticles under visible light and the photothermal effect generated under infrared light, the problem of difficult removal of biofilm in diabetic wounds in existing technologies has been solved, and a highly efficient wound healing effect has been achieved.

CN120860205APending Publication Date: 2025-10-31SOUTHWEST JIAOTONG UNIV
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Patent Information

Application Number
CN202511087563.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-08-05
Publication Date
2025-10-31

AI Technical Summary

Technical Problem

Existing methods for treating diabetic wound infections are insufficient to completely remove biofilms, leading to recurrent infections. Furthermore, long-term use of antibiotics may cause bacterial resistance. Surgical debridement causes pain and trauma to patients, and the efficacy and safety of anti-biofilm agents have not yet been verified.

Method used

We developed composite microneedles with photocatalytic function, which were prepared by casting with a specific mold. The nanoparticles were loaded onto the needle tip and used photocatalysis to generate H2, which oxidizes glucose to reduce the glucose level in the wound, producing a photothermal effect and a photocatalytic reaction, clearing the biofilm and promoting healing.

Benefits of technology

Under visible and infrared light irradiation, composite microneedles can effectively oxidize stress-induced biofilms, reduce glucose levels in diabetic wounds, generate H2 to kill bacteria, promote wound healing, and achieve cure of biofilm infections.

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Abstract

The invention belongs to the technical field of biomedical materials, and particularly relates to a composite microneedle for diabetes wound repair and application of the composite microneedle. According to the invention, a specific mold design is adopted, and the photocatalytic nanoparticles are accurately loaded on the tip part of the microneedle, so that the photocatalytic function application of the microneedle in the medical or biological field is realized. The preparation method has the advantages of being easy and convenient to operate, high in precision, good in repeatability and the like, and powerful support is provided for further development of the microneedle technology. In the process of promoting healing of diabetic wounds, the photocatalytic nanoparticles reduce the glucose level of the diabetic wounds under irradiation of visible light, generate H2 to eliminate inflammation, relieve oxidative stress and regulate and control polarization of macrophages at the same time, and then promote healing of the wounds. The photocatalytic composite microneedle is expected to become a novel multifunctional biological material for removing biofilms and promoting healing of diabetic wounds, and has a good application prospect in clinical treatment of the diabetic wounds.
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