Therapeutic corneal contact lens with far infrared function

Abstract

The invention discloses a therapeutic corneal contact lens with a far infrared function, and belongs to the technical field of medical precision instruments. A far infrared nanometer material is embedded in a lens body of the contact lens. A far-infrared nano material layer is embedded between the two layers of lens bodies in contact with the palpebral conjunctiva and the bulbar conjunctiva; or the far-infrared nano material is dispersed in the lens body, so that far-infrared energy can be stably released, regeneration and repair of corneal epithelium tissues are actively promoted, physical protection is provided, and the problem of corneal epithelium repair of a patient suffering from xerophthalmia is effectively solved.

Description

Technical Field

[0001] This invention belongs to the field of medical precision instrument technology, and in particular relates to a therapeutic corneal contact lens with far-infrared function. Background Technology

[0002] Dry eye syndrome, a prevalent eye disease worldwide, is closely linked to changes in modern social structure. Accelerated population aging, widespread use of electronic video devices, and the increasing prominence of sleep disorders have collectively contributed to the continuous rise in its prevalence. Patients often suffer from multiple discomforts, including dry eyes, persistent burning sensation, photophobia, a foreign body sensation, severe pain, and visual impairment, significantly impacting their quality of life. Pathologically, dry eye patients experience significantly lower than normal tear secretion, leading to an abnormally high tear osmotic pressure, which in turn induces a cascade of ocular surface inflammation. This inflammatory environment continuously deteriorates the corneal epithelial microenvironment, greatly increasing the probability of corneal epithelial damage. Clinical observations show individual differences in the severity of ocular surface damage; mild cases present as superficial punctate keratitis, while severe cases can progress to corneal ulcers, corneal tissue dissolution, or even corneal perforation—serious complications that endanger vision. Without timely intervention, irreversible visual impairment can result.

[0003] Current clinical treatment strategies primarily rely on artificial tears, topical anti-inflammatory drugs, and the physical protection of conventional corneal bandage lenses. Artificial tears only temporarily relieve dry eye symptoms and cannot repair damaged corneal epithelium; while anti-inflammatory drugs can suppress the inflammatory response, they pose potential side effects with long-term use; and traditional corneal bandage lenses, as a physical barrier, can reduce secondary damage to the cornea from external stimuli, but lack the therapeutic function of actively promoting tissue regeneration. Far-infrared technology exhibits unique advantages in tissue repair. Its specific wavelengths of energy can penetrate biological tissues, effectively improving local microcirculation, enhancing tissue oxygenation, activating fibroblast proliferation, and promoting collagen synthesis through photobiological regulation, thereby significantly accelerating the healing process of various skin wounds. Clinical applications of this technology in areas such as skin trauma and diabetic foot ulcers have demonstrated its safety and reliability. However, integrating far-infrared functional safety into corneal contact lens materials faces multiple challenges: on the one hand, the eye tissue is highly sensitive, requiring functional materials to possess excellent biocompatibility and long-term stability; on the other hand, silicone hydrogel, as the mainstream lens substrate, has a compatibility conflict with the hydrophobic tendency of far-infrared functional nanoparticles, leading to the nanoparticles easily agglomerating or precipitating, making it difficult to achieve uniform and stable dispersion within the lens, severely restricting the realization of active therapeutic functions. Current technology has not yet developed a corneal bandage lens product that can provide both physical protection and continuously release therapeutic far-infrared energy. Summary of the Invention

[0004] The purpose of this invention is to provide a therapeutic corneal contact lens with far-infrared function, which can stably release far-infrared energy, actively promote corneal epithelial tissue regeneration and repair, and provide physical protection, effectively solving the corneal epithelial repair problem in patients with dry eye syndrome.

[0005] To achieve the above objectives, the present invention provides the following technical solution: In a first aspect, the present invention provides a therapeutic corneal contact lens with far-infrared function, wherein far-infrared nanomaterials are embedded in the lens body of the contact lens.

[0006] As one possible approach, a layer of far-infrared nanomaterials is embedded between the two layers of the endoscope that contact the palpebral conjunctiva and the bulbar conjunctiva; or, the far-infrared nanomaterials are dispersed within the endoscope. As one possible approach, the mirror body is made of silicon hydrogel, and the far-infrared nanomaterial is a ceramic nanomaterial containing germanium, titanium, and selenium. As one possible implementation, silicone hydrogels are formed by the polymerization reaction of the following components: Siloxane monomer: 30-70 parts; Hydrophilic monomer: 30-50 parts; Crosslinking agent: 0.2-1.0 parts; Initiator: 0.3-2 parts; Solvent: 10-40 parts; Additional materials: 5-20 portions; The siloxane monomer is a mixture of symmetrical monomethacryloxypropyl modified polydimethylsiloxane (MCS-M11) or asymmetric monomethacryloxypropyl-terminated polydimethylsiloxane (MCR-M11) with propylene-terminated ethylene oxide-dimethylsiloxane-ethylene oxide ABA block copolymer and (3-methacryloxy-2-hydroxypropoxy)propylbis(trimethylsiloxy)methylsilane (SIGMA); the crosslinking agent is one or more of trimethylolpropane trimethacrylate (TMPTMA), trimethylolpropane triacrylate (TMPTA), or ethoxylated trimethylolpropane triacrylate (TMP3EOTA); the auxiliary materials are biocompatibility agents and cosolvents; Therapeutic contact lenses are molded from materials containing the following components: Silicone hydrogel: 0.05-3 parts; Far-infrared nanomaterials: 97-99.95 parts. As one possible implementation, the mirror body is made of a curable silicone composition; Far-infrared nanomaterials are one or a combination of ceramic powder, bamboo charcoal powder, tourmaline powder, germanium powder, titanium powder, graphene powder, nano copper powder, cordierite powder, and mullite powder. In this process, far-infrared nanomaterials are adhered between two mirror layers by an adhesive; the adhesive is one or a combination of natural resins or artificial resins. As one possible approach, therapeutic contact lenses can emit far-infrared light in the 4–400 micrometer wavelength range. As one possible approach, the weight ratio of far-infrared nanomaterials to therapeutic corneal contact lenses is 0.05% to 3%. As one possible approach, a far-infrared nanomaterial layer is embedded between the two layers of the lens that contact the palpebral conjunctiva and the bulbar conjunctiva. In this case, the far-infrared nanomaterial layer is 0.1–0.4 mm thick. As one possible approach, therapeutic contact lenses have an oxygen permeability of 95–115, a refractive index of 1.385–1.396, and a light transmittance of 93.3%–97.4%. Compared with the prior art, the present invention has the following advantages: 1. This invention sandwiches a far-infrared functional material in the central layer of the corneal contact lens matrix. This functional material continuously releases far-infrared rays of a specific wavelength at room temperature, acting on the meibomian gland tissue to promote meibomian gland secretion and improve meibomian quality, thereby alleviating dry eye symptoms. On the other hand, the specific wavelength of far-infrared radiation can stimulate the function of limbal stem cells, thereby promoting the repair of corneal epithelial damage. It plays a positive role in the treatment of dry eye at both the symptom and sign levels.

[0007] 2. This invention utilizes a safe and efficient far-infrared functional material, through specific materials science and process engineering methods, to manufacture an active therapeutic corneal contact lens incorporating far-infrared functional material. This not only retains the protective function of traditional contact lenses but also transforms them into an "active therapeutic" medical device capable of continuously and stably emitting far-infrared rays with photobiological effects onto the damaged cornea, activating and accelerating the corneal epithelial regeneration process at the cellular metabolic level, thus providing a novel technical solution for resolving refractory corneal lesions.

[0008] 3. The active therapeutic corneal contact lens with far-infrared functional material provided by the present invention can actively promote healing, that is, the continuously emitted far-infrared rays directly act on the corneal wound, promote cell metabolism and epithelial creep, and shorten the healing time.

[0009] 4. The active therapeutic corneal contact lens with far-infrared functional material provided by the present invention can provide long-lasting analgesia, that is, the gentle thermal effect can relieve nerve ending stimulation and significantly reduce the patient's pain and foreign body sensation.

[0010] 5. The active therapeutic corneal contact lens with far-infrared functional material provided by the present invention has high oxygen permeability and protection. That is, based on silicone hydrogel material, it ensures sufficient oxygen supply to the cornea during wear, while providing excellent mechanical protection.

[0011] 6. The active therapeutic corneal contact lens with far-infrared functional material provided by the present invention is convenient to use, that is, the therapeutic function is integrated into the inside of the lens, and patients can receive 24-hour uninterrupted physical therapy while wearing it, which greatly improves compliance.

[0012] 7. The active therapeutic contact lens with far-infrared functional materials provided by this invention has a wide range of applications. On the one hand, it can be used to treat dry eye: to improve dry eye symptoms. For example, it is suitable for people with myopia who wear contact lenses to correct their vision, and people who use video terminals such as computers and mobile phones for long periods of time. On the other hand, it can also be used for corneal epithelial repair: to promote corneal epithelial repair. For example, it is suitable for people whose corneal epithelium is damaged due to dry eye. Attached Figure Description

[0013] The accompanying drawings, which are provided to further illustrate the invention and constitute a part of this invention, are illustrative embodiments of the invention and their descriptions are used to explain the invention and do not constitute an undue limitation of the invention.

[0014] Figure 1 A schematic diagram of the overall structure of a therapeutic corneal contact lens with far-infrared function in use, provided in an embodiment of the present invention; Figure 2 A cross-sectional view of a therapeutic corneal contact lens with far-infrared function in use, provided in an embodiment of the present invention; Figure 3 This is a top view of a therapeutic corneal contact lens with far-infrared function in use, as provided in an embodiment of the present invention.

[0015] Figure label: 1-Mirror body, 2-Far-infrared nanomaterial layer, 3-Pupil area. Detailed Implementation

[0016] To facilitate a clear description of the technical solutions in the embodiments of the present invention, the terms "first" and "second" are used to distinguish identical or similar items with essentially the same function and effect. For example, the first threshold and the second threshold are merely used to distinguish different thresholds and do not limit their order. Those skilled in the art will understand that the terms "first" and "second" do not limit the quantity or execution order, and that the terms "first" and "second" are not necessarily different.

[0017] It should be noted that in this invention, the terms "exemplary" or "for example" are used to indicate examples, illustrations, or descriptions. Any embodiment or design described as "exemplary" or "for example" in this invention should not be construed as being more preferred or advantageous than other embodiments or designs. Specifically, the use of terms such as "exemplary" or "for example" is intended to present the relevant concepts in a concrete manner.

[0018] In this invention, "at least one" refers to one or more, and "more than one" refers to two or more. "And / or" describes the relationship between related objects, indicating that three relationships can exist. For example, A and / or B can represent: A alone, A and B simultaneously, or B alone, where A and B can be singular or plural. The character " / " generally indicates that the preceding and following related objects are in an "or" relationship. "At least one of the following" or similar expressions refer to any combination of these items, including any combination of single or plural items. For example, at least one of a, b, or c can represent: a, b, c, a combination of a and b, a combination of a and c, a combination of b and c, or a, b, and c, where a, b, and c can be single or multiple.

[0019] See Figures 1 to 3 This invention proposes a therapeutic corneal contact lens with far-infrared function, in which far-infrared nanomaterials are embedded in the lens body.

[0020] Among them, therapeutic corneal contact lenses with far-infrared functionality can be understood as corneal contact lenses that achieve active therapeutic effects by integrating far-infrared technology. Specifically, such contact lenses not only provide physical barrier protection but also promote ocular surface tissue repair through the release of far-infrared energy. For example, similar technical effects can be achieved by embedding micron-sized particles or coatings with far-infrared emitting capabilities into the lens body. Furthermore, the embedding of far-infrared nanomaterials can be achieved by pre-dispersing the nanomaterials in a liquid substrate before lens body molding, or by layering the material during lens body curing. The main purpose is to ensure that the far-infrared functional materials can be uniformly distributed within the lens body and maintain long-term stability.

[0021] The innovation of this invention lies in directly integrating far-infrared functional materials into the lens structure of the corneal contact lens, thus solving the problem in existing technologies that cannot simultaneously achieve physical protection and active therapeutic functions. In practical applications, traditional corneal contact lenses can only provide a physical barrier, while the introduction of far-infrared function can improve local microcirculation and activate tissue regeneration mechanisms, thereby meeting the need for both protective and repair functions in the treatment of ocular surface diseases such as dry eye.

[0022] The working principle of this invention is as follows: A therapeutic corneal contact lens with far-infrared function combines physical protection and active therapeutic functions by embedding far-infrared nanomaterials within the lens body 1. The lens body 1, as the basic structure, provides the necessary physical barrier, effectively isolating the ocular surface from secondary damage caused by external stimuli. Furthermore, the far-infrared nanomaterials are directly embedded inside the lens body. This embedding method ensures the uniform distribution and long-term stability of the nanomaterials within the lens body 1, avoiding functional failure due to aggregation or precipitation. Therefore, when wearing this corneal contact lens, the far-infrared nanomaterials continuously release far-infrared energy of a specific wavelength. This energy penetrates biological tissue, improving local microcirculation through photobiological regulation and activating fibroblast proliferation, thereby promoting the repair and regeneration of corneal epithelial tissue. Specifically, this design not only solves the problem of traditional corneal contact lenses only providing physical protection and lacking active therapeutic functions, but also overcomes the compatibility contradiction between the far-infrared functional material and the lens substrate, enabling the corneal contact lens to provide a physical barrier while exerting the therapeutic effect of far-infrared radiation, achieving a synergistic effect in promoting ocular surface repair. As a preferred embodiment, this technical solution provides a novel corneal contact lens solution that combines protection and treatment for patients with dry eye syndrome and other corneal injuries.

[0023] The present invention further proposes that a far-infrared nanomaterial layer 2 is embedded between the two layers of the lens body 1 that contact the palpebral conjunctiva and the bulbar conjunctiva (avoiding the pupil area 3); or, the far-infrared nanomaterial is dispersed in the lens body.

[0024] Specifically, the far-infrared nanomaterial layer 2 refers to an independent structural layer in which far-infrared nanomaterials are concentrated and distributed between the two lens layers 1 through a specific process. It can be formed by uniformly coating the far-infrared nanomaterials with an adhesive onto the surface of the lens 1, or by using a sandwich encapsulation technology to fix the far-infrared nanomaterials between the two lens layers 1. The purpose of this design is to ensure that far-infrared energy can accurately act on key areas of the ocular surface, while avoiding energy attenuation caused by disordered distribution of materials inside the lens.

[0025] In practical applications, dispersing far-infrared nanomaterials in the mirror body 1 can be understood as utilizing the polymerization properties of the mirror body 1 material to uniformly embed far-infrared nanoparticles into the matrix network during the mirror body 1 molding process. This dispersion strategy can be achieved through processes such as in-situ polymerization, solution mixing, or melt blending. Its purpose is to alleviate the contradiction between the hydrophilicity of silica hydrogels and the hydrophobicity of nanomaterials, and to prevent particle migration and precipitation.

[0026] In detail, both of the above technical approaches optimize material layout around the needs of ocular surface treatment. For the design of embedding a far-infrared nanomaterial layer 2 between the two lens layers 1, based on the anatomical characteristics of the ocular surface, the material is concentrated in the interface area where the lens directly contacts the palpebral and bulbar conjunctiva, allowing far-infrared energy to precisely radiate to the ocular surface tissues vulnerable to dry eye. The independent layer structure reduces direct conflict between nanoparticles and the hydrophilic matrix through physical isolation, inhibiting the aggregation tendency of hydrophobic materials caused by environmental changes, thereby maintaining uniform energy output. The method of dispersing far-infrared nanomaterials within the lens utilizes the lens's own structure to encapsulate and fix the nanoparticles, ensuring the continuous stability of far-infrared function throughout the lens's service life. These two solutions not only adapt to the process feasibility of different material systems but also ensure the effective regulation of the corneal epithelial microenvironment by far-infrared energy.

[0027] The above technical solution effectively overcomes the defect of easy aggregation and precipitation of far-infrared nanomaterials in the lens body 1, realizes the stable release and targeted effect of far-infrared function, and provides a reliable solution for solving the problem of tissue repair function deficiency in the treatment of dry eye syndrome.

[0028] The embodiments of the present invention further propose that the material of the mirror body 1 is silicon hydrogel, and the far-infrared nanomaterial is a ceramic nanomaterial containing germanium, titanium and selenium.

[0029] Specifically, silicone hydrogels refer to a type of polymeric material with a siloxane-based structure and hydrophilic properties. They can be achieved using a mixture of symmetrical monomethacryloxypropyl-modified polydimethylsiloxane or asymmetric monomethacryloxypropyl-terminated polydimethylsiloxane with specific block copolymers. This material selection aims to provide high oxygen permeability and good biocompatibility while meeting the basic wearing requirements of contact lenses. Far-infrared nanomaterials refer to ceramic nanoparticles composed of germanium, titanium, and selenium. Their hydrophobicity can be reduced by optimizing the elemental ratio and surface chemistry, thereby enhancing their dispersion stability in a hydrophilic matrix. The purpose of introducing this material is to resolve the compatibility conflict between hydrophilic substrates and hydrophobic functional materials, ensuring the uniform distribution and continuous release of far-infrared functionality.

[0030] In detail, the above technical solution specifically addresses the material compatibility issue by limiting the lens body 1 material to silicone hydrogel and the far-infrared nanomaterials to ceramic nanomaterials containing germanium, titanium, and selenium. Silicone hydrogel, a commonly used substrate for corneal contact lenses, meets basic wearing requirements due to its high oxygen permeability and biocompatibility; however, its hydrophilic properties can easily cause repulsion with hydrophobic nanomaterials. The selection of ceramic nanomaterials containing germanium, titanium, and selenium as the far-infrared functional material is based on the synergistic effect of these elements, which can significantly improve the interfacial stability of the material in a hydrophilic environment. This specific combination effectively inhibits the aggregation and precipitation of nanoparticles, thereby ensuring that the far-infrared function is uniformly distributed and continuously released within the lens body. Furthermore, the above technical solution is combined with techniques for embedding far-infrared nanomaterials, further enhancing the functionality and reliability of therapeutic corneal contact lenses and showcasing the ingenuity of the overall design.

[0031] The above technical solution not only resolves the compatibility conflict between hydrophilic substrates and hydrophobic functional materials, but also achieves stable distribution and continuous release of far-infrared function in the lens body, providing a better technical path for therapeutic corneal contact lenses.

[0032] This invention further proposes that the silicone hydrogel is formed by the polymerization reaction of the following components: siloxane monomer: 30-70 parts; hydrophilic monomer: 30-50 parts; crosslinking agent: 0.2-1.0 parts; initiator: 0.3-2 parts; solvent: 10-40 parts; auxiliary materials: 5-20 parts. The siloxane monomer is a mixture of symmetrical monomethacryloxypropyl modified polydimethylsiloxane MCS-M11 or asymmetric monomethacryloxypropyl-terminated polydimethylsiloxane MCR-M11 with propylene-terminated ethylene oxide-dimethylsiloxane-ethylene oxide ABA block copolymer and (3-methacryloxy-2-hydroxypropoxy)propylbis(trimethylsiloxy)methylsilane SIGMA; the crosslinking agent is one or more of trimethylolpropane trimethacrylate (TMPTMA), trimethylolpropane triacrylate (TMPTA), or ethoxylated trimethylolpropane triacrylate (TMP3EOTA); the auxiliary materials are biocompatibility agents and cosolvents. Therapeutic corneal contact lenses are molded from the following components: silicone hydrogel: 0.05-3 parts; far-infrared nanomaterials: 97-99.95 parts.

[0033] In practical applications, siloxane monomers are key components used to construct the hydrophobic regions of silicone hydrogels. These can be achieved using symmetrical monomethacryloyloxypropyl-modified polydimethylsiloxane MCS-M11 or a mixture of asymmetrical monomethacryloyloxypropyl-terminated polydimethylsiloxane MCR-M11 with ABA block copolymers and SIGMA. The aim is to regulate the molecular structure of the hydrophobic regions to achieve a complementary match with the surface properties of far-infrared nanomaterials, thereby inhibiting the aggregation tendency of nanoparticles. Hydrophilic monomers, on the other hand, are functional monomers used to maintain the compatibility of the lens with tear fluid. These can be achieved using combinations of monomers with different hydrophilic groups. The purpose is to balance the hydrophilicity and mechanical strength of the lens, avoiding mechanical property degradation due to excessive hydrophilicity. Specifically, the crosslinking agent is a key component used to construct the polymer network. It can be achieved using one or more combinations of trimethylolpropane trimethacrylate (TMPTMA), trimethylolpropane triacrylate (TMPTA), or ethoxylated trimethylolpropane triacrylate (TMP3EOTA). Its purpose is to form a moderately crosslinked network structure to anchor the nanomaterials and maintain elasticity to adapt to corneal movement. Furthermore, the biocompatibility agent in the auxiliary materials can be a polysaccharide or protein compound, aimed at enhancing the affinity of the material to the ocular surface tissue; the solubilizer can be a low-molecular-weight alcohol or ether compound, aimed at reducing interfacial tension to enhance dispersion stability.

[0034] Specifically, the above scheme achieves uniform and stable dispersion of far-infrared nanomaterials in a silica hydrogel matrix through systematic optimization of the proportions and selection of each component. The specific type and proportion range of siloxane monomers can finely control the structure of hydrophobic regions, matching the surface properties of the far-infrared nanomaterials and effectively inhibiting aggregation. The appropriate proportion of hydrophilic monomers maintains compatibility between the lens and tear film while providing a stable hydrophilic microenvironment, preventing nanomaterial precipitation. The selection and precise dosage of crosslinking agents construct a moderately crosslinked polymerization network, both anchoring the nanomaterials to prevent migration and maintaining sufficient elasticity to adapt to corneal movement. The appropriate addition of initiators ensures the sufficiency and uniformity of the polymerization reaction, forming a dense and defect-free matrix structure. The optimized solvent ratio improves the fluidity of the reaction system, promoting thorough mixing of components before polymerization. The biocompatibility and cosolvent in the auxiliary materials enhance the affinity between the material and ocular surface tissues and the interface modification effect, respectively. During the molding stage, a specific ratio of silicone hydrogel to far-infrared nanomaterials achieves a balance between the high-performance material loading capacity and the matrix fixation capacity, allowing the nanomaterials to be firmly integrated into the mirror body and ensuring the continuous and stable release of far-infrared energy.

[0035] The above technical solution solves the problem of dispersion stability of far-infrared nanomaterials in a silicone hydrogel matrix, ensuring the functional reliability and biosafety of therapeutic contact lenses in ocular applications. Furthermore, this solution, combined with the overall design of the aforementioned therapeutic contact lenses with far-infrared functionality, further enhances the overall performance of the lens, including biocompatibility, mechanical strength, and the stability of the far-infrared function, thereby significantly improving the treatment outcomes for patients with dry eye syndrome.

[0036] The present invention further proposes the above-mentioned therapeutic corneal contact lens, wherein the material of the lens body 1 is a curable organosilicon composition; the far-infrared nanomaterial is one or a combination of ceramic powder, bamboo charcoal powder, tourmaline powder, germanium powder, titanium powder, graphene powder, nano copper powder, cordierite powder, and mullite powder; wherein the far-infrared nanomaterial is adhered between the two lens bodies by an adhesive; the adhesive is one or a combination of natural resin or artificial resin.

[0037] In practical applications, curable silicone compositions refer to silicone-based materials with specific chemical structures and curing properties. These can be achieved using polysiloxane prepolymers containing active functional groups in conjunction with appropriate curing agent systems. The purpose of this material system selection is to overcome the compatibility conflict between traditional hydrophilic materials and far-infrared nanomaterials, ensuring the stable integration of nanoparticles during material molding. Far-infrared nanomaterials refer to functional microparticles with specific far-infrared emission capabilities. These can be surface-modified ceramic powders, bamboo charcoal powders, etc., to enhance interfacial adhesion with the silicone substrate. Adhesives are polymeric materials with excellent biocompatibility and bonding strength. These can be systems such as epoxy resins and acrylate resins, aiming to firmly fix the far-infrared nanomaterials between the mirror layers and prevent functional failure during use.

[0038] Specifically, this technical solution effectively solves the problem of dispersion stability of far-infrared nanomaterials in the lens body 1 by using a curable organosilicon composition with more suitable hydrophobic properties as the lens body 1 material. The specified far-infrared nanomaterial types all possess good far-infrared emission capabilities and suitable surface properties, enabling them to form a stable composite system with the organosilicon substrate. By placing the far-infrared nanomaterials between the two lens body layers 1 and fixing them with an adhesive, this design not only avoids the aggregation problem that may be caused by the direct dispersion of nanomaterials within a single material, but also ensures the structural integrity of the therapeutic functional layer. The selection of the adhesive fully considers the special requirements of the ocular environment; its excellent biocompatibility and erosion resistance maintain the long-term stability of the nanomaterial layer. Based on the above design, this solution successfully achieves the safe integration of far-infrared function with the corneal contact lens material system, providing physical protection while continuously releasing therapeutic far-infrared energy, significantly improving the product's therapeutic effect.

[0039] The present invention further proposes that therapeutic corneal contact lenses can emit far-infrared rays in the 4-400 micrometer wavelength range.

[0040] Specifically, the 4–400 micrometer band refers to the effective energy range determined based on the penetration characteristics of far-infrared rays in biological tissues and the mechanism of photobiological effects. In practical applications, the selection of this band range can be achieved using biological adaptation analysis methods supported by experimental data. The aim is to ensure that far-infrared energy can safely penetrate the tear film and corneal surface, and can also specifically improve local microcirculation and enhance tissue oxygenation levels.

[0041] In detail, the aforementioned technical solution effectively solves the problem of matching treatment energy with the characteristics of ocular tissue by limiting the far-infrared emission band to 4–400 micrometers. Based on this, the band design avoids the risk of thermal damage that may be caused by short-wave infrared radiation, while ensuring moderate energy depth to act on the corneal epithelial microenvironment. The energy in this specific band can activate fibroblast activity and collagen synthesis, thereby achieving continuous repair of ocular surface damage. Furthermore, when far-infrared nanomaterials are embedded in the lens body, this band control further enhances the active treatment capability of the contact lens and avoids the uncertainties brought about by non-therapeutic bands through precise energy distribution, organically unifying physical protection and biostimulation effects. This design not only improves the stability of treatment effects but also significantly reduces potential safety risks.

[0042] The embodiments of the present invention further propose that the weight ratio of far-infrared nanomaterials to therapeutic corneal contact lenses is 0.05% to 3%.

[0043] In practical applications, far-infrared nanomaterials refer to nanoscale particles that emit far-infrared rays. These can be achieved using ceramic nanomaterials containing germanium, titanium, and selenium, or by using one or a combination of materials such as ceramic powder, bamboo charcoal powder, tourmaline powder, germanium powder, titanium powder, graphene powder, nano-copper powder, cordierite powder, and mullite powder. The purpose of setting this ratio range is to balance the dispersion stability of the nanomaterials within the mirror with the effectiveness of the far-infrared function.

[0044] Specifically, by controlling the weight ratio of far-infrared nanomaterials to the lens body between 0.05% and 3%, aggregation caused by an excessively high ratio can be effectively avoided, thus maintaining the physical integrity and biocompatibility of the lens. Simultaneously, this ratio range ensures the continuous release of far-infrared function during long-term wear, providing reliable support for corneal epithelial repair. Based on optimized material interface compatibility, this ratio range not only ensures the stability of key lens performance such as oxygen permeability and light transmittance but also achieves effective photobiological modulation of ocular surface tissues. Furthermore, this ratio range also applies when the far-infrared nanomaterial layer is embedded between two layers of the lens body contacting the palpebral conjunctiva and bulbar conjunctiva, ensuring the uniformity and stability of the far-infrared nanomaterial layer and further improving treatment efficacy.

[0045] The above technical solution resolves the inherent contradiction between the hydrophilic properties of the silicone hydrogel substrate and the hydrophobic tendency of the far-infrared nanomaterials, achieving uniform and stable dispersion of nanomaterials in the lens body, and providing corneal contact lens products that combine physical protection and continuous far-infrared therapy for patients with dry eye syndrome.

[0046] The present invention further proposes that a far-infrared nanomaterial layer 2 is embedded between the two layers of the lens that contact the palpebral conjunctiva and the bulbar conjunctiva. In this case, the far-infrared nanomaterial layer is 0.1 to 0.4 mm thick.

[0047] Specifically, the far-infrared nanomaterial layer 2 refers to a functional interlayer containing far-infrared functional nanoparticles formed between the two lens layers 1. This can be achieved by uniformly dispersing far-infrared nanomaterials in an adhesive to form a coating, which is then fixed between the two lens layers 1 using a hot-pressing or photocuring process. The purpose of introducing this feature is to ensure that far-infrared energy can act on the ocular surface tissue in a stable and controllable manner, while avoiding aggregation or precipitation problems caused by improper layer thickness.

[0048] In detail, this technical solution achieves effective integration and optimization of far-infrared functionality by setting a far-infrared nanomaterial layer 2 of a specific thickness range between two lens layers 1. The thickness range of 0.1–0.4 mm is precisely designed to ensure sufficient nanomaterial density to maintain effective emission of therapeutic far-infrared rays, while avoiding excessive thickness that could obstruct oxygen permeation, thus protecting corneal health. Furthermore, this thickness range, through control of the spatial distribution density of nanoparticles, significantly reduces the risk of aggregation and precipitation, ensuring the stability of far-infrared functionality during long-term use without affecting the lens's biocompatibility and wearing comfort. Based on this design, the far-infrared nanomaterial layer can directly act on the ocular surface tissue, optimizing the photobiological modulation effect on microcirculation and tissue repair, thereby effectively solving the problems of uneven nanomaterial distribution and insufficient functional stability.

[0049] The above technical solution not only achieves stable release of far-infrared therapy function, but also takes into account the oxygen permeability and wearing comfort of the lens, providing an innovative solution for dry eye patients that combines physical protection and active treatment functions.

[0050] The embodiments of the present invention further propose that the oxygen permeability of the therapeutic corneal contact lens is 95-115; the refractive index is 1.385-1.396; and the light transmittance is 93.3%-97.4%.

[0051] Specifically, oxygen permeability refers to the lens material's ability to allow oxygen to pass through, which can be achieved by selecting highly breathable silicone hydrogel materials. Refractive index refers to the lens material's ability to refract light, which can be achieved by adjusting the composition ratio of the lens material, such as optimizing the ratio of siloxane monomers to hydrophilic monomers. Light transmittance refers to the lens's ability to allow light to pass through, which can be achieved by controlling the particle size and dispersion uniformity of far-infrared nanomaterials. Precise control of these parameters aims to ensure that, even after integrating far-infrared nanomaterials, the lens maintains a balance between corneal health and visual function.

[0052] In detail, the key performance parameters in the aforementioned therapeutic corneal contact lenses are closely related and work together. The oxygen permeability range is set at 95–115, ensuring sufficient oxygen supply to the corneal tissue and avoiding the risk of hypoxia caused by the addition of far-infrared nanomaterials, thus supporting the stability of the corneal epithelial microenvironment. The refractive index is set at 1.385–1.396, a value that matches the physiological optical characteristics of the human eye, ensuring that the vision correction effect is not interfered with after the introduction of far-infrared nanomaterials, providing a clear visual experience. The light transmittance range is set at 93.3%–97.4%, a high value range that effectively suppresses light scattering phenomena that may be caused by far-infrared nanomaterials, maintaining efficient light transmission through the lens, preventing visual blurring, and ensuring comfort in daily use. The synergistic control of these parameters solves the performance fluctuation problem caused by material compatibility in the integration of far-infrared functions, allowing the therapeutic lens to provide active treatment without sacrificing basic optical and physiological performance.

[0053] The above technical solution not only solves the problem of potential performance degradation caused by adding far-infrared nanomaterials, but also achieves good wearing safety and visual quality while providing therapeutic functions. This design fully considers the high sensitivity of eye tissues, ensuring the stability and reliability of the lens during long-term use.

[0054] Although the invention has been described herein in conjunction with various embodiments, those skilled in the art will understand and implement other variations of the disclosed embodiments by reviewing the accompanying drawings, disclosure, and other materials. In this specification, the word "comprising" does not exclude other components or steps, and "a" or "an" does not exclude multiple components. A single processor or other unit can implement several functions listed in the specification. While certain measures are described in different embodiments, this does not mean that these measures cannot be combined to produce good results.

[0055] Although the invention has been described in conjunction with specific features and embodiments, it is obvious that various modifications and combinations can be made therein without departing from the spirit and scope of the invention. Accordingly, this specification and drawings are merely illustrative of the invention and are considered to cover any and all modifications, variations, combinations, or equivalents within the scope of the invention. Clearly, those skilled in the art can make various alterations and modifications to the invention without departing from its spirit and scope. Thus, if such modifications and modifications fall within the scope of the invention and its equivalents, the invention is also intended to include such modifications and modifications.

Claims

1. A therapeutic corneal contact lens with far-infrared function, characterized in that, Far-infrared nanomaterials are embedded in the body of the contact lens.

2. The therapeutic corneal contact lens with far-infrared function according to claim 1, characterized in that, A layer of far-infrared nanomaterials is embedded between the two layers of the endoscope that contact the palpebral conjunctiva and the bulbar conjunctiva; or, far-infrared nanomaterials are dispersed in the endoscope.

3. The therapeutic corneal contact lens with far-infrared function according to claim 1, characterized in that, The mirror body is made of silicone hydrogel, and the far-infrared nanomaterials are ceramic nanomaterials containing germanium, titanium, and selenium.

4. The therapeutic corneal contact lens with far-infrared function according to claim 3, characterized in that, Silicone hydrogels are formed by the polymerization reaction of the following components: Siloxane monomer: 30-70 parts; Hydrophilic monomer: 30-50 parts; Crosslinking agent: 0.2-1.0 parts; Initiator: 0.3-2 parts; Solvent: 10-40 parts; Additional materials: 5-20 portions; The siloxane monomer is a mixture of symmetrical monomethacryloxypropyl modified polydimethylsiloxane (MCS-M11) or asymmetric monomethacryloxypropyl-terminated polydimethylsiloxane (MCR-M11) with propylene-terminated ethylene oxide-dimethylsiloxane-ethylene oxide ABA block copolymer and (3-methacryloxy-2-hydroxypropoxy)propylbis(trimethylsiloxy)methylsilane (SIGMA); the crosslinking agent is one or more of trimethylolpropane trimethacrylate (TMPTMA), trimethylolpropane triacrylate (TMPTA), or ethoxylated trimethylolpropane triacrylate (TMP3EOTA); the auxiliary materials are biocompatibility agents and cosolvents. Therapeutic contact lenses are molded from materials containing the following components: Silicone hydrogel: 0.05-3 parts; Far-infrared nanomaterials: 97-99.95 parts.

5. The therapeutic corneal contact lens with far-infrared function according to claim 1, characterized in that, The mirror body is made of a curable silicone composition; Far-infrared nanomaterials are one or a combination of ceramic powder, tourmaline powder, germanium powder, titanium powder, graphene powder, nano copper powder, cordierite powder, and mullite powder. In this process, far-infrared nanomaterials are adhered between two mirror layers by an adhesive; the adhesive is one or a combination of natural resins or artificial resins.

6. The therapeutic corneal contact lens with far-infrared function according to claim 1, characterized in that, Therapeutic contact lenses can emit far-infrared rays in the 4–400 micrometer wavelength range.

7. The therapeutic corneal contact lens with far-infrared function according to claim 1, characterized in that, The weight ratio of far-infrared nanomaterials to therapeutic corneal contact lenses is 0.05% to 3%.

8. The therapeutic corneal contact lens with far-infrared function according to claim 1, characterized in that, A far-infrared nanomaterial layer is embedded between the two layers of the lens that contact the palpebral conjunctiva and the bulbar conjunctiva. At this time, the far-infrared nanomaterial layer is 0.1-0.4 mm thick.

9. The therapeutic corneal contact lens with far-infrared function according to claim 1, characterized in that, The oxygen permeability of therapeutic contact lenses is 95–115; the refractive index is 1.385–1.396; and the light transmittance is 93.3%–97.4%.

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