Traditional Chinese medicine composition as well as preparation method and application thereof

By combining traditional Chinese medicines such as cinnamon twig, poria cocos, peony bark, peach kernel, white peony root, dipsacus root, processed epimedium, and sparganium rhizome, and preparing granules and other dosage forms, the problem of unclear effects of existing traditional Chinese medicines in treating bladder outlet obstruction has been solved. This has achieved significant reduction in prostate index and sex hormone levels, and improved the therapeutic effect of bladder outlet obstruction.

CN122097522APending Publication Date: 2026-05-29JIANGSU KANION PHARMA CO LTD
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Patent Information

Application Number
CN202411737080.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-11-29
Publication Date
2026-05-29

AI Technical Summary

Technical Problem

The existing Chinese medicine drugs have unclear mechanisms of action in treating benign prostatic hyperplasia (BPH), making them difficult to effectively target prostatic hyperplasia caused by multiple etiologies. Furthermore, minimally invasive surgery and Western medicine treatments carry the risk of complications.

Method used

A traditional Chinese medicine composition is provided, consisting of cinnamon twig, poria cocos, peony bark, peach kernel, white peony root, dipsacus root, processed epimedium, and sparganium rhizome. It is prepared into dosage forms such as granules and capsules through compounding and extraction, and is used to treat benign prostatic hyperplasia, with synergistic therapeutic effects.

Benefits of technology

This traditional Chinese medicine composition significantly reduces the prostate index in model mice and rats, alleviates interstitial edema, lowers serum sex hormone levels, and improves bladder outlet obstruction and prostatic hyperplasia. It has a significant therapeutic effect on benign prostatic hyperplasia and is superior to the use of Guizhi Fuling capsules alone or the combination of Chuanduan + Zhiyinyanghuo + Sanleng.

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Abstract

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition and preparation and application thereof. The composition provided by the invention comprises cassia twig, poria cocos, moutan bark, peach kernel, white paeony root, dipsacus root, roasted herba epimedii and rhizoma sparganii. According to the composition, the prostate index and the thickness of prostate epithelium of a benign prostatic hyperplasia model rat can be obviously reduced, and interstitial edema can be relieved; the composition provided by the invention can obviously reduce the contents of dihydrotestosterone, estradiol, testosterone, gonadotropin releasing hormone and rat luteinizing hormone in model mouse prostate serum, and increase the content of follicle stimulating hormone. The results show that the traditional Chinese medicine composition can inhibit sex hormone disorder and has the effect of treating benign prostatic hyperplasia.
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