A fully automatic hemorheology analyzer and its analysis method

Abstract

The application discloses a full-automatic hemorheology analyzer and an analysis method thereof, and belongs to the field of intelligent medical treatment. The pressure-time change curve collected in real time by the full-automatic hemorheology analyzer during blood flow is acquired, and corresponding flow velocity data is calculated; the whole blood viscosity, the plasma viscosity and the blood sedimentation basic index are calculated based on the pressure-flow velocity data, and a plurality of derivative indexes are generated through a preset conversion model; the plurality of derivative indexes are compared with a preset clinical reference range, the cause of blood viscosity abnormality is judged in combination with a multi-index combination logic, an auxiliary diagnosis conclusion for a target chronic disease and a physiological and pathological change distinguishing prompt are output; and a blood circulation improvement recipe scheme, a meridian metabolism regulation scheme and a full-nutrition guidance scheme are automatically generated according to the hemorheology detection result and the auxiliary diagnosis conclusion, and a comprehensive report sheet is integrated and output; and the problems of mechanical wear, low integration, weak index decoupling capability and lack of closed-loop management of a traditional hemorheology analyzer are solved.

Description

Technical Field

[0001] This application relates to the field of smart medical technology, and in particular to a fully automated blood rheology analyzer and its analysis method. Background Technology

[0002] Hemorheological testing is an important tool for assessing blood viscosity, erythrocyte deformability, and aggregation ability, and has significant clinical value for early screening, diagnosis, and monitoring of treatment efficacy for chronic diseases such as cardiovascular and cerebrovascular diseases. However, existing hemorheological analyzers and their analytical methods still have the following significant limitations in practical applications.

[0003] In terms of hardware structure, there are problems with mechanical wear and low integration. Traditional blood rheology analyzers mostly use capillary or cone-plate measurement principles, relying on mechanical rotors, pistons, and other moving parts to directly contact and drive blood flow. This mechanical contact not only easily cuts and damages red blood cells, leading to distorted measurement data, but also easily causes mechanical wear during long-term operation, resulting in high equipment failure rate, short service life, and high maintenance costs. In addition, the internal functional modules of existing equipment (such as sample introduction, detection, cleaning, and waste discharge) are scattered, with low system integration, making it difficult to achieve truly one-click, high-throughput, fully automated detection, and still requiring a lot of manual intervention.

[0004] In terms of data analysis and clinical application, there are problems with weak indicator decoupling ability and a lack of closed-loop management. Existing hemorheology detection systems typically only output basic physical indicators such as whole blood viscosity and plasma viscosity, lacking effective algorithms to eliminate interfering factors such as hematocrit. This makes it difficult to accurately isolate and quantify the rheological properties of red blood cells (such as deformability and aggregation) and abnormal plasma components, making it difficult for doctors to accurately determine the root cause of abnormal blood viscosity. At the same time, existing equipment has limited functionality, remaining at the "data measurement" level, lacking a logical model that deeply binds multidimensional hemorheological indicators with the auxiliary diagnosis of clinical chronic diseases (such as coronary heart disease and diabetes); moreover, it cannot automatically generate targeted comprehensive intervention guidance plans such as nutritional diet and meridian metabolism based on test results, making it difficult to meet the closed-loop needs of modern chronic disease early screening, monitoring, and full-cycle health management. Summary of the Invention

[0005] To address the deficiencies in the aforementioned background technology, this application provides a fully automated hemorheology analyzer and its analysis method.

[0006] This application is achieved through the following technical solution.

[0007] A fully automated blood rheology analyzer includes: a housing assembly and a base plate assembly;

[0008] The housing assembly includes a housing and an integrated unit; the integrated unit is fixed to the housing.

[0009] The large base plate assembly is fixed inside the housing assembly. The large base plate assembly includes a large base plate component and, fixed to the large base plate component, a liquid suction component, a vertical plate component, a mounting bracket component, a power supply component, a pump component, a pipe connector component, and a circuit interface component. The liquid suction component enables automatic rotation of the measuring disc orifice and linear movement of the suction needle (forward, backward, up, and down). The vertical plate component enables liquid pressure detection and liquid heating. The circuit board in the mounting bracket component controls the liquid flow direction and the movement of the suction needle and measuring disc. The power supply component supplies power to the internal circuitry and drives the motor. The pump component controls the liquid suction volume. The pipe connector component connects the internal and external pipes. The circuit interface component connects the internal and external circuits.

[0010] During operation, blood samples are introduced into the syringe and related fluid paths of the upright plate assembly through the aspiration component, forming a closed fluid path system. A specific initial pressure is applied to the sealed fluid path by the pump assembly, driving the blood to flow within the tube. During the flow, the circuit board controls the pressure to continuously decrease. Due to the continuous pressure change, the flow rate of the blood sample also changes accordingly. The pressure sensor in the upright plate assembly collects the pressure change curve over time during the pressure decrease process in real time and transmits it to the integrated machine, which calculates and outputs a comprehensive blood rheology analysis report.

[0011] Optionally, the liquid aspiration assembly includes: a mounting base plate, a slide rail column, a horizontal slide rail assembly, a vertical slide rail assembly, a cleaning tube, a cleaning tube fixing bend plate, a measuring plate assembly, a limit sensor, and a limit sensor fixing bend plate;

[0012] The slide rail column is fixed to the mounting base plate; the horizontal slide rail assembly is fixed to the slide rail column; the vertical slide rail assembly is fixed to the slider of the horizontal slide rail assembly; the cleaning pipe is fixed to the cleaning pipe fixing bend plate, and the cleaning pipe fixing bend plate is fixed to the horizontal slide rail assembly; the measuring disc assembly is fixed to the mounting base plate; the limit sensor is installed on the limit sensor fixing bend plate, and the limit sensor fixing bend plate is fixed to the mounting base plate.

[0013] Optionally, the upright plate assembly includes: a sample bottle bottom plate, a sample bottle upright plate, a syringe straight connector, a syringe syringe, a pressure sensor, a pressure sensor bent plate, a first two-way solenoid valve, a sample bottle, a thermistor pressure plate, a thermistor, a second two-way solenoid valve, a first three-way solenoid valve, a heating shaft, and a heating shaft fixing bent plate.

[0014] The sample bottle upright plate is fixed to the sample bottle bottom plate; the syringe straight connector is installed into the syringe barrel, and the flange fits; the syringe straight connector and the syringe barrel flange are installed into the rectangular hole of the sample bottle upright plate and fixed; the pressure sensor is fixed to the pressure sensor bent plate, and the pressure sensor bent plate is fixed to the sample bottle upright plate; the first two-way solenoid valve and the sample bottle are fixed to the sample bottle upright plate; the thermistor is installed into the heating shaft, the thermistor pressure plate is fixed on the heating shaft, the heating shaft is fixed to the heating shaft fixing bent plate, and the heating shaft fixing bent plate is fixed to the sample bottle upright plate; the second two-way solenoid valve and the first three-way solenoid valve are also fixed to the sample bottle upright plate.

[0015] Optionally, the fixing frame assembly includes: a fixing frame, a waste liquid bottle, a waste liquid bottle cap, a second three-way solenoid valve, a third three-way solenoid valve, a third two-way solenoid valve, a fourth three-way solenoid valve, a solenoid valve fixing bend plate, and a circuit board.

[0016] The waste liquid bottle cap is inserted into the waste liquid bottle, and the flange is fitted; the flange of the waste liquid bottle and the waste liquid bottle cap are inserted into the rectangular hole of the fixing frame for fixation; the second three-way solenoid valve and the third three-way solenoid valve are fixed on the solenoid valve fixing plate, and the solenoid valve fixing plate is fixed on the fixing frame; the third two-way solenoid valve and the fourth three-way solenoid valve are also fixed on the solenoid valve fixing plate; the circuit board is fixed on the fixing frame.

[0017] Optionally, the pump assembly includes a peristaltic pump assembly, a pump isolation cover, a diaphragm pump, a diaphragm pump mounting plate, and shock-absorbing screws;

[0018] One end of some of the shock-absorbing screws is fixed to the peristaltic pump assembly, and the other end is fixed to the base plate assembly with a nut; the diaphragm pump is fixed to the diaphragm pump mounting plate; one end of another set of shock-absorbing screws is fixed to the diaphragm pump mounting plate, and the other end is fixed to the base plate assembly with a nut; the pump isolation cover is fixed to the base plate assembly.

[0019] An analysis method based on the fully automated hemorheology analyzer, executed by an integrated machine, includes the following steps:

[0020] Acquire the pressure-time curves collected in real time by a fully automated blood rheology analyzer during blood flow and calculate the corresponding flow velocity data;

[0021] Based on pressure-flow rate data, the basic indicators of whole blood viscosity, plasma viscosity and erythrocyte sedimentation rate are calculated, and multiple derived indicators are generated through a preset conversion model. The multiple derived indicators include relative / reduced viscosity at each shear rate, erythrocyte aggregation / rigidity / deformation / electrophoresis index, blood yield stress and erythrocyte sedimentation rate equation K value.

[0022] By comparing multiple derived indicators with preset clinical reference ranges and combining the logic of multiple indicator combinations, the cause of abnormal blood viscosity is determined, and auxiliary diagnostic conclusions for the target chronic disease and suggestions for distinguishing between physiological and pathological changes are output.

[0023] Based on the results of blood rheology testing and auxiliary diagnostic conclusions, the system automatically generates a blood circulation improvement diet plan, a meridian metabolism regulation plan, and a comprehensive nutrition guidance plan, and integrates and outputs a comprehensive blood rheology analysis report.

[0024] Optionally, the step of acquiring the pressure-time curve collected in real time by the fully automated hemorheology analyzer during blood flow and calculating the corresponding flow velocity data specifically includes:

[0025] according to Real-time absolute pressure value collected by the pressure sensor Using formula Calculate the average blood flow velocity ;in express The volume of the sealed air column above the syringe barrel at any given time; This represents the cross-sectional area of ​​the syringe barrel; This represents the derivative of pressure with respect to time, i.e., the pressure decay rate.

[0026] Optionally, the calculation of basic indicators of whole blood viscosity, plasma viscosity, and erythrocyte sedimentation rate based on pressure-flow rate data specifically includes:

[0027] Using formula Calculate the shear stress on the blood ;in Indicates the inner radius of the syringe barrel; This indicates the pressure difference between the two ends of the syringe barrel; Indicates the effective length of the syringe barrel;

[0028] Using formula Calculate the shear rate of blood. ;in Indicates instantaneous volumetric flow rate;

[0029] Using formula Calculate the dynamic viscosity of blood ;

[0030] As the pressure continues to decrease, based on real-time calculations... and This generates a continuous viscosity-shear rate curve;

[0031] The viscosity values ​​of whole blood high / medium / low shear viscosity are obtained by extracting the average value of a specific shear rate point or interval from the viscosity-shear rate continuous curve.

[0032] Calculated from blood samples at arbitrary shear rates Value as plasma viscosity;

[0033] When a blood sample is at rest, the distance the red blood cell interface descends per unit time is measured as the erythrocyte sedimentation rate (ESR).

[0034] Optionally, the step of comparing multiple derived indicators with preset clinical reference ranges, combining multi-indicator combination logic to determine the cause of abnormal blood viscosity, and outputting auxiliary diagnostic conclusions for the target chronic disease and prompts for distinguishing between physiological and pathological changes specifically includes:

[0035] When whole blood low-shear viscosity and erythrocyte aggregation index are significantly elevated, it indicates the risk of microcirculatory perfusion disorder and can help predict coronary heart disease and ischemic stroke.

[0036] When whole blood high shear viscosity is abnormal and erythrocyte rigidity index is associated with metabolic indicators, it can aid in the diagnosis of diabetic microvascular complications.

[0037] When the viscosity of all shear rates in whole blood increases and is accompanied by abnormal red blood cell count, it may be a sign of polycythemia vera.

[0038] By establishing a time-series comparison model between individual baseline data and dynamic monitoring trends, physiological hemoconcentration and pathological hyperviscosity can be distinguished, which can be used to assist in early screening of chronic diseases, efficacy monitoring and intervention evaluation.

[0039] Optionally, the blood circulation improvement diet plan is generated based on matching 6 dietary assessment models and 4 nutritional guidance methods; the meridian metabolism conditioning plan is based on the theory of the twelve meridians in traditional Chinese medicine, and integrates current blood rheology detection results, environmental temperature and humidity data and the user's innate physical characteristics to calculate the meridian metabolism blockage index and output targeted conditioning strategies to reduce blood viscosity; the comprehensive nutrition guidance plan integrates dietary intervention and meridian conditioning suggestions to form a daily quantitative diet and a multi-dimensional health management path.

[0040] According to the specific embodiments provided in this application, the following technical effects are disclosed:

[0041] This application provides a fully automated blood rheology analyzer that employs third-generation pressure sensing technology. It drives blood flow by applying decreasing pressure to a closed fluid path via a pump assembly. No moving mechanical parts within the testing body (syringe barrel and related fluid paths) come into contact with the blood, achieving a zero-mechanical-wear design. This not only avoids damage to red blood cells from mechanical shear forces, significantly improving detection accuracy, but also significantly reduces equipment failure rate and extends service life. Furthermore, this application highly integrates the aspiration assembly, upright plate assembly, and pump valve control onto a large base plate assembly, resulting in a compact structure and enabling high-throughput, fully automated, one-button testing of 40 samples, significantly reducing manual operation costs and error risks. The analytical method provided in this application generates 14 derived indicators (such as relative / reduced viscosity, aggregation / rigidity / deformation index, etc.) through a preset conversion model, effectively eliminating interference from hematocrit and accurately focusing on the rheological properties of red blood cells and plasma components. Combined with multi-indicator combination logic, it can accurately determine the causes of abnormal blood viscosity, enabling auxiliary diagnosis of chronic diseases such as coronary heart disease and diabetes, and differentiation of physiological / pathological changes. Furthermore, this application establishes a closed loop of "detection-diagnosis-intervention," automatically generating blood circulation improvement diets, meridian metabolism regulation, and comprehensive nutrition guidance programs, providing multi-dimensional health management support for chronic diseases in middle-aged and elderly individuals throughout the entire process, and enhancing the clinical application value of the equipment. Attached Figure Description

[0042] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the embodiments will be briefly described below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0043] Figure 1 A schematic diagram of the overall appearance of a fully automated blood rheology analyzer;

[0044] Figure 2 This is a structural exploded diagram of a fully automated hemorheology analyzer.

[0045] Figure 3 This is an exploded view of the housing assembly 1.

[0046] Figure 4 This is an exploded view of the structure of the large base plate assembly 2;

[0047] Figure 5 This is an exploded view of the structure of the base plate assembly 11;

[0048] Figure 6 This is an exploded view of the liquid absorption assembly 12.

[0049] Figure 7This is an exploded view of the structure of the horizontal slide rail assembly 25;

[0050] Figure 8 This is an exploded view of the vertical slide rail assembly 26.

[0051] Figure 9 This is an exploded view of the structure of the measuring disk assembly 29;

[0052] Figure 10 This is an exploded view of the structure of the upright panel assembly 13;

[0053] Figure 11 This is an exploded view of the structure of the fixing frame assembly 14;

[0054] Figure 12 An exploded view of the power supply component 15;

[0055] Figure 13 This is an exploded view of the pump assembly 16.

[0056] Figure 14 This is an exploded view of the structure of the pipe fitting assembly 17.

[0057] Figure 15 This is an exploded view of the circuit interface component 18.

[0058] Figure 16 A schematic diagram of the overall operation process of a fully automated hemorheology analyzer;

[0059] Figure 17 This is a flowchart illustrating a fully automated hemorheological analysis method.

[0060] Figure 18 This is a schematic diagram of the human-computer interaction interface in one embodiment. Detailed Implementation

[0061] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0062] This application aims to address the problems of mechanical wear and low integration in traditional blood rheology analyzers, as well as the issues of weak indicator decoupling ability and lack of closed-loop management.

[0063] To make the above-mentioned objectives, features and advantages of this application more apparent and understandable, the application will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0064] In one exemplary embodiment, the overall appearance of the fully automated hemorheology analyzer of this application is as follows: Figure 1 As shown, where Figure 1 Part (a) shows a three-dimensional model of the fully automated blood rheology analyzer. Figure 1 Section (b) shows its three-dimensional line drawing. See further. Figure 2 The fully automated blood rheology analyzer can be divided into two main parts: the housing assembly 1 and the base plate assembly 2, which are connected and fixed by three sets of screws.

[0065] The disassembled structure of housing assembly 1 is as follows: Figure 3 As shown. See also Figure 3 The housing assembly 1 includes the housing 3, upper cover 4, small side door 5, side door cover 6, integrated unit 7, rear cover 8, rear small cover 9, and main switch 10. Specifically, the upper cover 4 is fixed to the housing 3 with Phillips head screws; removing it allows for troubleshooting of internal liquid aspiration components. The small side door 5 is fixed to the housing 3 with Phillips head screws; removing it allows for troubleshooting of liquid aspiration component sensor malfunctions. There are two side door covers 6, one on each side, fixed to the housing 3 with Phillips head screws; removing them allows for troubleshooting of internal malfunctions. The integrated unit 7 is fixed to the housing 3 with nuts and, in conjunction with software, is used to control the instrument's measurement process and calculate and output a comprehensive blood rheology analysis report. The rear cover 8 is fixed to the housing 3 with Phillips head screws; removing it allows for troubleshooting and repair of internal malfunctions. The rear small cover 9 is connected and fixed to the rear cover 8 by magnets; removing it allows for replacement of the internal peristaltic pump. The main switch 10 is fixed to the housing 3 with its own nut and is used to control the on and off of the all-in-one machine 7.

[0066] The overall structure of the large base plate assembly 2 is as follows: Figure 4 As shown, Figure 4 Part (a) is its front view. Figure 4 Part (b) is its rear view. See also Figure 4The base plate assembly 2 specifically includes a base plate component 11, a liquid suction component 12, a vertical plate component 13, a mounting bracket component 14, a power supply component 15, a pump component 16, a pipeline connector component 17, and a circuit interface component 18. The liquid suction component 12 is fixed to the base plate component 11 with Phillips head screws, enabling automatic rotation of the measuring disc hole and linear movement of the suction needle (forward, backward, up, and down). The vertical plate component 13 is fixed to the support column of the base plate component 11 with three-piece screws, enabling liquid pressure detection and liquid heating. The mounting bracket component 14 is fixed to the base plate component 11 with Phillips head screws; its circuit board controls the liquid flow direction, suction needle, and measuring disc movement. The power supply component 15 is fixed to the base plate component 11 with Phillips head screws, supplying power to the internal circuitry and driving the motor. The pump component 16 is fixed to the base plate component 11 with Phillips head screws and nuts, controlling the liquid suction volume. Pipe connector assembly 17 is fixed to base plate assembly 11 with Phillips head screws for connecting internal and external pipes. Circuit interface assembly 18 is fixed to base plate assembly 11 with Phillips head screws for connecting internal and external circuits.

[0067] Specifically, the disassembled structure of the base plate assembly 11 is as follows: Figure 5 As shown. See also Figure 5 The base plate assembly 11 includes a synchronous pulley axle cover 19, pads 20, a base plate 21, and support columns 22. The synchronous pulley axle cover 19 is fixed to the base plate 21 with Phillips head screws. The pads 20 are screwed into the base plate 21 for fixation. The three support columns 22 are fixed to the base plate 21 with three-piece combination screws.

[0068] The overall structure of the liquid aspiration assembly 12 is as follows: Figure 6 As shown. See also Figure 6 The liquid aspiration assembly 12 specifically includes a mounting base plate 23, a slide rail column 24, a horizontal slide rail assembly 25, a vertical slide rail assembly 26, a cleaning tube 27, a cleaning tube fixing bend plate 28, a measuring disc assembly 29, a limit sensor 30, and a limit sensor fixing bend plate 31. The slide rail column 24 is fixed to the mounting base plate 23 with Phillips head screws. The horizontal slide rail 25 is fixed to the slide rail column 24 with Phillips head screws. The vertical slide rail 26 is fixed to the slider of the horizontal slide rail 25 with Phillips head screws. The cleaning tube 27 is fixed to the cleaning tube fixing bend plate 28 with a nut, and the cleaning tube fixing bend plate 28 is fixed to the horizontal slide rail 25 with Phillips head screws. The measuring disc assembly 29 is fixed to the mounting base plate 23 with Phillips head screws. The limit sensor 30 is fixed to the limit sensor fixing bend plate 31 with Phillips head screws, and the limit sensor fixing bend plate 31 is fixed to the mounting base plate 23 with Phillips head screws.

[0069] The exploded structure of the horizontal slide rail assembly 25 is as follows: Figure 7 As shown. See also Figure 7The horizontal slide rail assembly 25 specifically includes a first stepper motor 32, a first limit sensor bracket 33, a first limit sensor 34, a horizontal slide rail fixing plate 35, a first miniature slide rail 36, a first active synchronous pulley 37, a first synchronous belt 38, a first synchronous belt pressure plate 39, a first slider connecting block 40, a slider connecting plate 41, a first optical wheel shaft 42, a first driven synchronous pulley 43, and a first sensor moving curved plate 44. The first stepper motor 32 is fixed to the horizontal slide rail fixing plate 35 with Phillips head screws. The first limit sensor 34 is fixed to the first limit sensor bracket 33 with copper posts and Phillips head screws. The first limit sensor bracket 33 is then fixed to the horizontal slide rail fixing plate 35 with Phillips head screws to control the endpoint of the backward movement of the suction needle and to serve as the initial position for the forward movement, allowing the stepper motor 32 to start counting steps. Two sets of first miniature slide rails 36 are fixed to the horizontal slide rail fixing plate 35 with Phillips head screws. The first active synchronous pulley 37 is fitted onto the shaft of the first stepper motor 32 and secured with its own set screw. The first driven synchronous pulley 43 is first fitted into the first optical wheel shaft 42, and then the first optical wheel shaft 42 is screwed onto the transverse slide rail fixing plate 35. The two first slider connecting blocks 40 are fixed onto the slider of the first miniature slide rail 36 with Phillips head screws. The first synchronous belt 38 is fitted onto the first active synchronous pulley 37 and the first driven synchronous pulley 43, and secured onto the first slider connecting block 40 with the first synchronous belt pressure plate 39. The slider connecting plate 41 is fixed onto the two first slider connecting blocks 40 with Phillips head screws to ensure synchronous movement of the two sliders. The first sensor moving bending plate 44 is fixed onto the transverse slide rail fixing plate 35 with Phillips head screws. In this transverse slide rail assembly 25, the first stepper motor 32 drives the slider to move through the synchronous belt transmission mechanism to achieve the linear movement of the suction needle, ensuring that the suction needle is accurately aligned with the hole of the cleaning tube 27 and the measuring plate.

[0070] The exploded structure of the vertical slide rail assembly 26 is as follows: Figure 8 As shown. See also Figure 8The vertical slide rail assembly 26 specifically includes a vertical slide rail fixing plate 45, a second stepper motor 46, a second limit sensor 47, a second limit sensor bracket 48, a second sensor moving bend plate 49, a second miniature slide rail 50, a second slider connecting block 51, a second driven synchronous wheel 52, a second optical wheel shaft 53, a second synchronous belt pressure plate 54, a second synchronous belt 55, a needle support bar 56, a liquid level detection plate 57, a needle guide post 58, a suction needle 59, a needle clamping post 60, a needle clamping fixing nut 61, a needle clamping locking nut 62, a flushing head 63, a flushing head U-shaped fixing fork 64, a flushing head fixing cross plate 65, a second active synchronous wheel 66, and a flushing head hose fixing bend plate 67. The second stepper motor 46 is fixed to the vertical slide rail fixing plate 45 with Phillips head screws. The second limit sensor 47 is fixed to the second limit sensor bracket 48 using copper posts and Phillips head screws. The second limit sensor bracket 48 is then fixed to the vertical slide rail fixing plate 45 using Phillips head screws. This controls the endpoint of the upward movement of the suction needle 59 and serves as the initial position for the downward movement, allowing the second stepper motor 46 to begin counting steps. The miniature slide rail 50 is fixed to the vertical slide rail fixing plate 45 using Phillips head screws. The second slider connecting block 51 is fixed to the slider of the second miniature slide rail 50 using Phillips head screws. The second limit sensor bracket 49 is fixed to the second slider connecting block 51 using Phillips head screws. The second driven synchronous wheel 52 is first inserted into the second optical wheel shaft 53, and then the second optical wheel shaft 53 is screwed into the vertical slide rail fixing plate 45. The second driving synchronous wheel 66 is inserted into the shaft of the second stepper motor 46 and fixed using its own set screw. The second synchronous belt 55 is fitted onto the second driving synchronous pulley 66 and the second driven synchronous pulley 52, and is fixed to the second slider connecting block 51 by the second synchronous belt pressure plate 54. The needle support bar 56 is fixed to the second slider connecting block 51 with a cross-head screw. The liquid level detection plate 57 is fixed to the needle support bar 56 with a copper post and a cross-head screw, and is used to detect the liquid level in the test tube and control the distance the suction needle 59 continues to travel after touching the liquid surface. The guide post 58 is first fitted onto the tail of the suction needle 59, and then the needle clamping post 60 is fitted onto the suction needle 59, inserted into the elongated hole of the needle support bar 56, and the needle clamping fixing nut 61 and the needle clamping locking nut 62 are screwed in in sequence. The needle guide post 58 is fixed to the needle support bar 56 with a cross-head screw. The flushing head 63 is interference-fitted onto the flushing head U-shaped fixing fork 64, and the flushing head fixing horizontal plate 65 is fixed to the vertical slide rail fixing plate 45 with a cross-head screw. The flushing head 63 is fitted onto the suction needle 59, and then the flushing head U-shaped fixing fork 64 is fixed to the flushing head fixing plate 65 with Phillips head screws. The flushing head hose fixing bend 67 is fixed to the vertical slide rail fixing plate 45 with Phillips head screws to fix the direction and position of the suction needle hose. In this vertical slide rail assembly 26, the second stepper motor 46 drives the slider to move through the synchronous belt transmission mechanism to realize the vertical linear movement of the suction needle 59, ensuring that the suction needle 59 accurately extends into the cleaning tube 27 and the measuring plate hole to complete the suction.

[0071] The exploded structure of the measuring disc assembly 29 is as follows: Figure 9 As shown. See also Figure 9 The measuring disc assembly 29 specifically includes a third driving synchronous pulley 68, a third synchronous belt 69, a third driven synchronous pulley 70, bearings 71, bearing sleeves 72, bearing covers 73, a rotating baffle 74, a lower test tube tray 75, a middle test tube tray 76, an upper test tube tray 77, a film 78, a decorative cover 79, a rotating shaft 80, and a third stepper motor 81. Two bearings 71 are respectively installed inside the bearing sleeves 72. The upper bearing is fixed to the bearing cover 73 with Phillips head screws, and the lower bearing is fixed to the mounting base plate 23. The lower test tube tray 75 and the middle test tube tray 76 are connected and fixed with brass posts and Phillips head screws, and then the lower test tube tray 75 is fixed to the middle flange of the rotating shaft 80 with Phillips head screws. The rotating baffle 74 is fixed to the rotating shaft 80 with Phillips head screws, and the rotating shaft 80 is assembled onto the bearing sleeve 72 through the bearings 71. The third synchronous belt 69 is fitted onto the third driving synchronous pulley 68 and the third driven synchronous pulley 70. Then, the third driven synchronous pulley 70 and the third driving synchronous pulley 68 are respectively fitted onto the third stepper motor 81 and the rotating shaft 80, and secured with their own set screws. The upper test tube tray 77 is aligned with the holes of the middle test tube tray 76 and the lower test tube tray 75, and secured to the rotating shaft 80 with Phillips head screws. The adhesive film 78 is attached to the upper test tube tray 77. The decorative cover 79 is screwed into the rotating shaft 80. In this measuring tray assembly 29, the third stepper motor 81 drives the rotating shaft to rotate via a synchronous belt drive mechanism, synchronizing the rotation of the measuring tray (test tube tray), for the automatic collection and injection of multiple blood samples.

[0072] In one exemplary embodiment, the first stepper motor 32, the second stepper motor 46, and the third stepper motor 81 are all 42-stepper motors.

[0073] The exploded structure of the upright panel assembly 13 is as follows: Figure 10 As shown. See also Figure 10The upright plate assembly 13 specifically includes a sample vial base plate 82, a sample vial upright plate 83, a syringe straight connector 84, a syringe barrel 85, a pressure sensor 86, a pressure sensor bend plate 87, a first two-way solenoid valve 88, a sample vial 89, a thermistor pressure plate 90, a thermistor 91, a second two-way solenoid valve 92, a first three-way solenoid valve 93, a heating shaft 94, and a heating shaft fixing bend plate 95. The sample vial upright plate 83 is fixed to the sample vial base plate 82 with three-piece combination screws. The syringe straight connector 84 is inserted into the syringe barrel 85, with the flange fitting, and fixed with self-tapping screws. Then, the syringe straight connector 84 and the flange of the syringe barrel 85 are inserted into the rectangular hole of the sample vial upright plate 83 and fixed with two cable ties. The pressure sensor 86 is fixed to the pressure sensor bend plate 87 with copper posts and Phillips head screws, and the pressure sensor bend plate 87 is fixed to the sample vial upright plate 83 with Phillips head screws. The first two-way solenoid valve 88 is fixed to the sample bottle upright plate 83 with Phillips head screws. The sample bottle 89 is fixed to the sample bottle upright plate 83 with Phillips head screws. The thermistor 91 is installed inside the heating shaft 94, and then the thermistor pressing plate 90 is fixed to the heating shaft 94 with Phillips head screws to fix the thermistor 91. The heating shaft 94 is fixed to the heating shaft fixing bend plate 95 with Phillips head screws, and the heating shaft fixing bend plate 95 is fixed to the sample bottle upright plate 83 with Phillips head screws. The second two-way solenoid valve 92 and the first three-way solenoid valve 93 are fixed to the sample bottle upright plate 83 with Phillips head screws.

[0074] The disassembled structure of the fixing bracket assembly 14 is as follows: Figure 11 As shown. See also Figure 11 The mounting bracket assembly 14 specifically includes a mounting bracket 96, a waste liquid bottle 97, a waste liquid bottle cap 98, a second three-way solenoid valve 99, a third three-way solenoid valve 100, a third two-way solenoid valve 101, a fourth three-way solenoid valve 102, a solenoid valve fixing plate 103, and a circuit board 104. The waste liquid bottle cap 98 is inserted into the waste liquid bottle 97, with the flange fitting, and secured with self-tapping screws. Then, the flanges of the waste liquid bottle 97 and the waste liquid bottle cap 98 are inserted into the rectangular holes of the mounting bracket 96 and secured with two cable ties. The second three-way solenoid valve 99 and the third three-way solenoid valve 100 are fixed to the solenoid valve fixing plate 103 with Phillips head screws. The third two-way solenoid valve 101 and the fourth three-way solenoid valve 102 are fixed to another solenoid valve fixing plate 103 with Phillips head screws. Both solenoid valve fixing plates 103 are then fixed to the mounting bracket 96 with Phillips head screws. The circuit board 104 is fixed to the mounting bracket 96 by nylon posts and Phillips head screws. In this mounting bracket assembly 14, a solenoid valve is used to control the flow of liquid; a waste liquid bottle 97 is used to store the waste liquid after instrument testing and cleaning for discharge outside the instrument; the circuit board 104 is connected to the integrated machine 7 to control the internal motor and solenoid valve of the instrument, so that the circuit and pipeline can perform various actions to complete the test.

[0075] The exploded structure of power supply component 15 is as follows: Figure 12 As shown. See also Figure 12 The power supply assembly 15 specifically includes a power mounting plate 105, motor drivers 106, an all-in-one adapter 107, an adapter cover 108, a switching power supply 109, and a switching power supply mounting plate 110. Five motor drivers 106 are fixed to the power mounting plate 105 with Phillips head screws, driving each stepper motor. The all-in-one adapter 107 is installed inside the adapter cover 108, which is fixed to the power mounting plate 105 with Phillips head screws. The switching power supply 109 is fixed to the switching power supply mounting plate 110 with Phillips head screws, and then the switching power supply mounting plate 110 is fixed to the power mounting plate 105 with Phillips head screws, providing power to the internal hardware of the instrument.

[0076] The exploded structure of pump assembly 16 is as follows: Figure 13 As shown. See also Figure 13 The pump assembly 16 specifically includes a peristaltic pump assembly 111, a pump isolation cover 112, a diaphragm pump 113, a diaphragm pump mounting plate 114, and multiple shock-absorbing screws 115. One end of some of the shock-absorbing screws 115 is fixed to the peristaltic pump assembly 111 with a Phillips head screw, and the other end is fixed to the base plate 21 with a nut. The diaphragm pump 113 is fixed to the diaphragm pump mounting plate 114 with a Phillips head screw. Similarly, one end of another set of shock-absorbing screws 115 is fixed to the diaphragm pump mounting plate 114 with a Phillips head screw, and the other end is fixed to the base plate 21 with a nut. The pump isolation cover 112 is fixed to the base plate 21 with a Phillips head screw. In the pump assembly 16, the peristaltic pump assembly 111 is used for precise control of the fluid flow rate for detection and cleaning; the diaphragm pump 113 is used to control the flow rate of waste liquid discharged from the instrument.

[0077] The exploded structure of the pipe fitting assembly 17 is as follows: Figure 14 As shown. See also Figure 14 The pipeline connector assembly 17 specifically includes a connector plate 116, a waste liquid connector 117, a cleaning fluid connector 118, and an air connector 119. The waste liquid connector 117 is used to discharge internally generated waste liquid from the instrument. The cleaning fluid is drawn into the internal pipelines via the peristaltic pump 111 through the flushing head connector 118, completing the cleaning of the internal pipelines. The air connector 119 connects external air to the internal hydraulic pipelines, maintaining consistent internal and external air pressure and ensuring smooth liquid flow within the pipelines. The waste liquid connector 117, cleaning fluid connector 118, and air connector 119 are fixed to the connector plate 116 with their own nuts. The connector plate 116 is fixed to the base plate 21.

[0078] The exploded structure of circuit interface component 18 is as follows: Figure 15 As shown. See also Figure 15The circuit interface assembly 18 specifically includes a three-in-one switch 120, a grounding post 121, a serial port connector 122, an interface board 123, a USB interface 124, and a network port 125. The three-in-one switch 120 is fixed to the interface board 123 with Phillips head screws and controls the power switch. The grounding post 121 is fixed to the interface board 123 with its own nut to ensure leakage grounding protection for the instrument. The serial port connector 122 is fixed to the interface board 123 with imperial copper posts and nuts to enable communication with the circuit board 104. The network port 125 is fixed to the interface board 123 with Phillips head screws to enable network connection. The USB interface 124 is fixed to the interface board 123 with Phillips head screws to enable data transmission between the instrument's external and internal systems.

[0079] In this fully automated hemorheology analyzer, the aspiration assembly structure achieves high-precision three-dimensional linear motion of the aspiration needle through the precise coordination of the horizontal and vertical slide rail components and the stepper motor synchronous belt drive mechanism. Combined with the limit sensor and liquid level detection plate, it ensures accurate alignment of the aspiration needle with the cleaning tube and the measuring disc hole, and enables adaptive liquid level detection, significantly improving the reliability of automatic sample introduction and anti-vacuuming. The vertical plate assembly structure clearly defines the specific mechanical assembly and sealing relationships of the syringe barrel, pressure sensor, heating shaft, and various solenoid valves, ensuring the stability of the sealed detection chamber and precise control of the constant temperature environment (37℃), providing a reliable hardware foundation for high-sensitivity, interference-free pressure attenuation data acquisition. The mounting frame assembly structure, through the rational layout of multiple sets of two-way / three-way solenoid valves and waste liquid bottles, optimizes the liquid path switching logic and waste liquid collection path, improving the thoroughness of pipeline cleaning, the accuracy of liquid path flow switching, and the smoothness of waste liquid discharge.

[0080] This application's fully automated blood rheology analyzer abandons the mechanical rotation measurement method of traditional capillary or cone-plate viscometers. It employs third-generation pressure sensing technology, enabling dynamic detection of blood viscosity with continuously changing shear rate during blood sample flow, providing data that more closely reflects the actual blood flow state in the human body. Furthermore, it utilizes a zero-mechanical-wear design, reducing component wear and extending service life while avoiding interference from mechanical wear on detection accuracy. Its core principle is "simulating the real blood flow environment in the human body," mainly including the following aspects.

[0081] Simulated blood flow scenario: A small amount of blood sample is introduced into the "sealed detection tube" (composed of syringe 85 and related fluid circuits) inside the instrument to form a closed fluid circuit system.

[0082] Pressure-driven and deceleration: A specific initial pressure is applied to the sealed fluid circuit via a pump and valve system, driving the blood to flow within the tube. During the flow, the system controls the pressure to continuously decrease.

[0083] Velocity-pressure dynamic correlation: Due to continuous pressure changes, the flow velocity of the blood sample also changes. This dynamic change covers 1-200 s. -1 Its wide shear rate range perfectly simulates the real hydrodynamic state of blood in the human body, from arteries to veins.

[0084] Data Acquisition and Viscosity Measurement: The built-in high-precision pressure sensor 86 collects complete data sets in real time during the pressure reduction process. The all-in-one machine 7 analyzes the blood flow velocity corresponding to different pressure values ​​and uses fluid dynamics algorithms to directly calculate whole blood viscosity (high / medium / low shear), plasma viscosity, and erythrocyte sedimentation rate, and converts them into multiple derived indicators.

[0085] Technical advantages: No mechanical moving parts in the entire detection fluid path come into contact with the blood, achieving zero mechanical wear. This avoids measurement errors caused by the traditional rotor cutting red blood cells and significantly reduces the failure rate.

[0086] The overall operation process of the fully automated hemorheology analyzer in this application is as follows: Figure 16 As shown. In actual one-button fully automatic testing, the mechanical components on the large base plate assembly 2, under the scheduling of the circuit board 104, cooperate precisely in the following timing stages.

[0087] Phase 1: Sample loading and automatic addressing (measurement tray and aspiration needle 59 working together).

[0088] Measuring disc rotation positioning: The operator places the test tube containing the blood sample into the three-layer test tube tray (upper / middle / lower layers, a total of 40 holes) of the measuring disc assembly 29. The second stepper motor 81 starts, driving the rotating shaft 80 and the entire measuring disc to rotate through the third synchronous belt 69 transmission mechanism, accurately rotating the target sample tube to the sampling position.

[0089] The three-dimensional motion process of the aspiration needle 59 is as follows.

[0090] Forward and backward movement (Y-axis): The first stepper motor 32 in the horizontal slide rail assembly 25 drives the slider to move on the first micro slide rail 36 through the first synchronous belt 38, pushing the vertical slide rail assembly 26 forward as a whole, so that the aspiration needle 59 is aligned with the sample tube.

[0091] Up and down movement (Z-axis): The second stepper motor 46 inside the vertical slide rail assembly 26 is started, driving the suction needle 59 to descend vertically.

[0092] Liquid level detection to prevent cavitation: During the descent of the aspiration needle 59, the liquid level detection plate 57 monitors in real time. When the tip of the aspiration needle touches the blood surface and a change in capacitance / resistance occurs, the current position is immediately recorded, and the aspiration needle 59 is controlled to continue descending a preset safe distance before stopping, ensuring accurate liquid aspiration without clogging the needle tip.

[0093] Phase 2: Sample aspiration and liquid transfer (pump and valve coordination).

[0094] Precise aspiration: After the aspiration needle 59 is in place, the peristaltic pump assembly 111 starts, precisely controlling the negative pressure of the fluid path, and aspirating a blood sample of a set volume (such as 20μl of peripheral blood or venous blood) into the internal fluid path through the aspiration needle.

[0095] Liquid circuit switching: At this time, the first two-way solenoid valve 88, the second two-way solenoid valve 92 and the first three-way solenoid valve 93 in the upright plate assembly 13 open and close according to the preset program, guiding the blood sample into the core detection chamber composed of the syringe barrel 85 and related liquid circuits, while removing air bubbles in the pipeline.

[0096] Phase 3: Constant temperature environment and core testing (coordination of vertical panel assembly 13 and sensor).

[0097] Constant temperature simulation: Before and during the test, the heating shaft 94 is powered on and heats up. Its internal thermistor 91 provides real-time temperature feedback to the integrated machine 7, ensuring that the test liquid path is always kept at a constant temperature close to the human body temperature (usually 37°C), eliminating the influence of temperature on blood viscosity.

[0098] Dynamic pressure acquisition: Pressure is applied to the sample inside the syringe barrel 85 to drive its flow. The pressure sensor 86 (fixed by the pressure sensor bend 87) records the complete curve data set of pressure decay over time / flow rate in real time at an extremely high sampling frequency, and transmits it to the integrated machine 7 for viscosity calculation.

[0099] Phase 4: Fully automated cleaning and waste liquid treatment (self-cleaning mechanism).

[0100] External cleaning: After the test is completed, the horizontal and vertical slide rails move the suction needle 59 above the cleaning tube 27. The rinsing head 63 sprays cleaning fluid to rinse the outer wall of the suction needle and prevent cross-contamination.

[0101] Internal pipeline cleaning: The integrated machine 7 switches three-way solenoid valves 99, 100, and 102, and the peristaltic pump 111 draws in pure water or special cleaning fluid from the cleaning fluid connector 118 to perform high-pressure flushing of the sealing detection tube and internal liquid circuit.

[0102] Waste liquid discharge: The waste liquid generated during cleaning and the blood samples after testing are forced into the waste liquid bottle 97 through the waste liquid connector 117 under the negative pressure suction of the diaphragm pump 113, awaiting manual disposal. The shock-absorbing screw 115 at the bottom of the diaphragm pump effectively reduces vibration and noise during discharge.

[0103] Phase 5: Data processing and multi-dimensional report output (electrical control and software systems).

[0104] Quality control and calculation: The software system inside the all-in-one machine 7 uses quality control materials to automatically correct test parameters and calculate multiple core indicators.

[0105] Solution generation: The system not only outputs clinical auxiliary diagnostic conclusions (such as risk warnings for coronary heart disease and diabetes), but also automatically generates daily recommended diets for improving blood circulation, metabolic conditioning plans based on the twelve meridians of traditional Chinese medicine, and comprehensive nutrition guidance plans based on algorithms. Finally, it outputs an A4 comprehensive report through a printer.

[0106] This fully automated blood rheology analyzer integrates a three-dimensional aspiration mechanism (horizontal / vertical slide rails), a 40-position rotary sample introduction mechanism (measuring plate), and a pressure sensing detection chamber (vertical plate assembly) onto a large base plate assembly, achieving a high-throughput detection of 40 samples / hour with a compact structure and high integration. Through a combination of a peristaltic pump (for fine sample introduction / cleaning), a diaphragm pump (for powerful waste removal), and multiple sets of solenoid valves (for fluid path logic switching), it achieves non-destructive transfer of micro-samples (20μl) and thorough self-cleaning of the tubing, improving the precision of fluid path control. Through closed-loop temperature control using a heating shaft and a thermistor, combined with pressure-decreasing fluid dynamics detection, it perfectly replicates the real rheological environment of human blood in blood vessels in its mechanical structure, improving the biomimeticity of the detection environment and ensuring the clinical accuracy of derived indicators (such as erythrocyte deformability / aggregation index).

[0107] Based on the aforementioned fully automated hemorheology analyzer, this application also provides a fully automated hemorheology analysis method, executed by the integrated machine 7, such as... Figure 17 As shown, it includes the following steps S1 to S4.

[0108] S1. Obtain the pressure-time curve collected in real time by the fully automated hemorheology analyzer during blood flow and calculate the corresponding flow velocity data.

[0109] This application's pressure-sensing blood rheometer is based on "simulating the human blood flow environment" and achieves blood viscosity detection through the following process: 1) Simulating blood flow scenario: placing a blood sample in a sealed detection tube, which can simulate the blood flow environment in the human body; 2) Pressure-driven flow: applying a specific pressure to the sealed detection tube to drive the blood sample to flow in the tube, and the pressure will continuously decrease during the flow; 3) Velocity-pressure correlation: due to the continuous change in pressure, the flow velocity of the blood sample changes as the pressure decreases; 4) Data acquisition and calculation: collecting a complete set of data on pressure changes, analyzing the blood flow velocity corresponding to different pressures, and finally calculating the blood viscosity value under different pressures.

[0110] In the fully automated hemorheology analyzer of this application, the syringe straight connector 84 is inserted into the syringe barrel 85, and the flanges fit together. These two components, when tightly assembled, together form a sealed cylindrical chamber. During actual testing, the blood sample is drawn into the lower half of this chamber, while a sealed air column remains in the upper half. When the blood flows out under gravity or external air pressure, the upper air column expands, causing a pressure drop. This chamber, formed by the "syringe + straight connector," is the "sealed detection tube" used for fluid dynamics calculations in the algorithm.

[0111] During testing, the integrated machine 7 controls the measuring disk assembly to rotate to the sampling position via the circuit board, driving the aspiration needle to draw up a blood sample and inject it into the sealed detection tube. A preset initial pressure is applied to the sealed detection tube and the pressure is continuously reduced. During the blood flow, pressure change data and corresponding flow rate data are collected in real time to obtain the dynamic characteristics of blood viscosity under continuous shear rate.

[0112] In the fully automated hemorheology analyzer of this application, the test body has no moving parts and zero mechanical wear. This means that there is no rotor or piston moving inside the sealed detection capillary (simplified as syringe barrel 85). Its actual working process is as follows: After the sample is drawn into the sealed detection capillary, a sealed air column (volume set to...) remains above the capillary. The system applies initial pressure to the air column via an external air source. This drives blood to flow out from the thin tube at the bottom. As blood flows out, the volume of the sealed air column above expands, causing its pressure to rise. The pressure decreases continuously. Pressure sensor 86 acquires the pressure-time curve in real time at an extremely high sampling frequency (e.g., 1000Hz). .

[0113] According to the ideal gas law (isothermal process) Based on the constant (=) and the fluid continuity equation, the instantaneous volumetric flow rate can be derived. Relationship with pressure decay rate:

[0114] (1);

[0115] in express The volume (m³) of the sealed air column above the capillary tube (simplified as syringe syringe 85) at all times. 3 The value can be calculated from the initial volume and the volume of liquid that has flowed out. express The real-time absolute pressure value (Pa) collected by the pressure sensor 86. The derivative of pressure with respect to time, i.e., the pressure decay rate, is calculated by differentiating or finitely analyzing the collected pressure-time curve.

[0116] Due to the average blood flow rate ,therefore:

[0117] (2);

[0118] in, This represents the instantaneous average flow velocity (m / s) of blood within the sealed detection capillary. The cross-sectional area (m²) of the capillary tube used for sealing testing 2 ), where is a known hardware constant.

[0119] In this application, blood flow velocity Instead of direct measurement using a physical flow velocity sensor, the velocity is indirectly and precisely calculated using a "pressure decay method" combined with the closed gas law. Specifically, this application utilizes the ideal gas law and the fluid continuity equation to indirectly and precisely calculate the instantaneous blood flow velocity by collecting the pressure decay rate of a closed air column. This algorithm avoids introducing a physical flow velocity sensor into the fluid path, further simplifying the hardware structure and completely eliminating the risk of measurement errors caused by sensor contamination.

[0120] S2. Calculate the basic indicators of whole blood viscosity, plasma viscosity and erythrocyte sedimentation rate based on pressure-flow rate data, and generate multiple derived indicators through a preset conversion model.

[0121] The fully automated hemorheology analyzer described in this application can cover multiple core indicators such as blood viscosity, red blood cell function, and plasma characteristics through "direct testing + conversion calculation," providing precise data support for the diagnosis and treatment of chronic diseases in middle-aged and elderly people.

[0122] Specifically, this application uses the Hagen-Poiseuille law to convert the real-time calculated "flow velocity" and the "pressure" collected by the sensor into "shear rate" and "shear stress", and then obtains the viscosity.

[0123] Among them, shear stress It is generated by the pressure difference that drives blood flow, and its calculation formula is as follows:

[0124] (3);

[0125] in, This represents the shear stress (Pa) experienced by the blood. This indicates the inner radius (m) of the sealing test tube. This represents the pressure difference (Pa) across the capillary tube used for sealing detection, which in this system is approximately equal to the gauge pressure measured by the sensor. . This represents the effective length (m) of the sealed detection tube, which is approximately the length of 85mm syringe barrel.

[0126] shear rate It reflects the velocity gradient of blood flow, and its calculation formula is as follows:

[0127] (4);

[0128] in, The shear rate of blood (s) −1 ); Instantaneous volumetric flow rate (m³) 3 / s).

[0129] Based on the definition of viscosity (the ratio of shear stress to shear rate), the formula for calculating blood viscosity is as follows:

[0130] (5);

[0131] in, The dynamic viscosity of blood (Pa·s or mPa·s).

[0132] The extraction methods for high / medium / low shear viscosity and plasma viscosity are as follows.

[0133] Whole blood high / medium / low shear viscosity: shear rate during a continuous decrease in pressure. It is continuously changing (covering 1~200s) −1 The all-in-one machine 7 will calculate in real time. and The system generates a continuous viscosity-shear rate curve. Using an algorithm, it extracts the viscosity value at a specific shear rate point (or the average value of an interval) from this curve, which can then be used as the high / medium / low shear viscosity of whole blood. For example, extracting... =200s −1 Near values ​​are considered high shear viscosity. =50s −1 As the mid-shear viscosity =1s −1 Or 10s −1 As a low-shear viscosity.

[0134] Plasma viscosity: Plasma is a Newtonian fluid, and its viscosity does not change with shear rate. The system directly takes blood samples at any shear rate (usually 100 s). −1 Or 120s −1 ) calculated under Value, as plasma viscosity.

[0135] Erythrocyte sedimentation rate (ESR): ESR measurement typically does not rely on pressure decay. The instrument usually has an independent photoelectric monitoring channel (or a high-precision liquid level tracking algorithm) that monitors the distance (mm / h) the red blood cell interface descends per unit time (1 hour) when the blood sample is at rest. This application does not improve the ESR measurement method, therefore it will not be described further.

[0136] This application, based on the Hagen-Poiseuille law, converts pressure and flow velocity into shear stress and shear rate, achieving a range of 1-200 s. -1 Continuous and dynamic blood viscosity detection over a wide shear rate range allows the test data to perfectly match the actual hemodynamic state of the human body, thus improving the reference value of clinical data.

[0137] The integrated machine 7 can directly detect whole blood viscosity (high / medium / low shear, reflecting erythrocyte deformability and aggregation), plasma viscosity (related to plasma components), and erythrocyte sedimentation rate (ESR). Further calculations can yield multiple derivative indicators, including relative / reduced viscosity at various shear rates (eliminating hematocrit interference and focusing on the rheological properties of erythrocytes themselves), erythrocyte aggregation / rigidity / deformation / electrophoresis index, blood yield stress, and the K-value of the ESR equation, comprehensively capturing key information on blood viscosity, erythrocyte function, and flow resistance.

[0138] The essence of these various derived indicators is to eliminate the interference of hematocrit (HCT, the volume ratio of red blood cells in blood), thereby purely reflecting the deformability, aggregation capacity, or plasma composition of red blood cells themselves. Calculating these indicators requires the introduction of external input parameters or instrument-estimated hematocrit (HCT). The following is a detailed introduction to the specific conversion methods for each derived indicator.

[0139] relative viscosity The viscosity is divided into three categories: high, medium, and low shear rates, reflecting the ratio of whole blood viscosity to plasma viscosity. The following formula is used for calculation:

[0140] (6);

[0141] in Indicates the first Relative viscosity at shear rate (dimensionless). Indicates the first Whole blood viscosity (mPa·s) at shear rate. This represents plasma viscosity (mPa·s).

[0142] Reduced viscosity It is also divided into three parameters: high, medium, and low shear rate, which are the core indicators of this application. They eliminate the influence of hematocrit (HCT) concentration and purely reflect the rheological properties of erythrocytes themselves. The calculation formula is as follows:

[0143] (7);

[0144] in Indicates the first Reduced viscosity (mPa·s) at shear rate. This indicates the hematocrit (expressed as a decimal, such as 0.45).

[0145] This application utilizes pressure sensing technology to achieve fully automated, safe, and rapid blood viscosity detection. Based on the test results, it generates a comprehensive nutritional guidance plan, which can ensure blood health while achieving comprehensive prevention and control of cardiovascular and cerebrovascular diseases.

[0146] Erythrocyte aggregation index This reflects the tendency of erythrocytes to overlap and aggregate at low shear rates (highly correlated with low shear viscosity), and the calculation formula is as follows:

[0147] (8);

[0148] in, This indicates the low-shear viscosity of whole blood. This indicates the high shear viscosity of whole blood.

[0149] Red blood cell rigidity index This reflects the deformability of red blood cells under high shear rates. The greater the rigidity, the worse the deformability. The calculation formula is as follows:

[0150] (9);

[0151] in, This indicates the high-shear viscosity of whole blood.

[0152] Red blood cell deformability index It directly reflects the deformability of red blood cells under shear force, and the calculation formula is as follows:

[0153] (10);

[0154] Among them, the red blood cell deformability index The lower the value, the stiffer the red blood cells are and the worse their deformability.

[0155] Red blood cell electrophoretic index Reflecting the electrical charge state of red blood cell surfaces, the lower the charge, the easier it is for cells to aggregate. This can be estimated using parameters such as erythrocyte sedimentation rate (ESR) and hematocrit.

[0156] (11);

[0157] in, This refers to the erythrocyte sedimentation rate (ESR). This is hematocrit.

[0158] Blood yield stress This represents the minimum shear stress required for blood to begin flowing. Below this stress, blood behaves as an elastic solid. It is obtained by nonlinearly fitting data at low shear rates using the Casson equation:

[0159] (12);

[0160] in, This represents the measured shear stress. The yield stress (Pa) is the fitting parameter. The limiting viscosity (fitting parameter) is the viscosity at infinite shear rate. Let be the shear rate.

[0161] The erythrocyte sedimentation rate (ESR) is greatly affected by the hematocrit (HCT) (the lower the hematocrit, the faster the ESR). The K-value of the ESR equation is used to eliminate the interference of HCT on the ESR and truly reflect the aggregation of red blood cells. The calculation formula is as follows:

[0162] (13);

[0163] in, The measured erythrocyte sedimentation rate (mm / h) is given. K represents the erythrocyte sedimentation rate (ESR) equation value. A larger K value indicates stronger erythrocyte aggregation. Since the denominator in the formula is negative, the absolute value is usually taken in actual calculations.

[0164] This application generates multiple derived indicators (such as relative / reduced viscosity, aggregation / rigidity / deformation index, etc.) through a preset conversion model (6)~(13), effectively eliminating the interference of hematocrit and accurately focusing on the rheological properties of erythrocytes and plasma components. The conversion model eliminates the interference of hematocrit through reduced viscosity calculation to focus on the rheological properties of erythrocytes, associates abnormal plasma protein components with plasma viscosity, and distinguishes between abnormal erythrocyte count and abnormal erythrocyte characteristics through the ratio logic of erythrocyte deformability index and aggregation index.

[0165] S3. Compare multiple derived indicators with preset clinical reference ranges, combine multi-indicator combination logic to determine the cause of abnormal blood viscosity, and output auxiliary diagnostic conclusions for the target chronic disease and suggestions for distinguishing between physiological and pathological changes.

[0166] In clinical practice, a combination of indicators can be used to accurately determine the cause of abnormal blood viscosity (such as abnormal red blood cell count / characteristics, abnormal plasma components), assisting in the diagnosis of chronic diseases such as coronary heart disease, diabetes, and polycythemia vera. At the same time, it can distinguish between physiological and pathological changes, and help with early screening, monitoring, and intervention assessment of chronic diseases.

[0167] The clinical auxiliary diagnostic process includes: when whole blood low shear viscosity and erythrocyte aggregation index are significantly elevated, it indicates a risk of microcirculatory perfusion disorders and helps in the early warning of coronary heart disease and ischemic stroke; when whole blood high shear viscosity and erythrocyte rigidity index are abnormal and associated with metabolic indicators, it helps in the diagnosis of diabetic microvascular complications; when the viscosity of all shear rates of whole blood is elevated and accompanied by abnormal erythrocyte count indicators, it helps in the diagnosis of polycythemia vera; by establishing a time-series comparison model of individual baseline data and dynamic monitoring trends, physiological hemoconcentration and pathological hyperviscosity state can be distinguished, which can be used to assist in early screening of chronic diseases, efficacy monitoring and intervention evaluation.

[0168] This application establishes a clear mapping relationship between abstract rheological indicators and specific clinical pathological features of chronic diseases (such as microcirculation perfusion disorders and increased erythrocyte rigidity), thereby improving the sensitivity and specificity of early screening for chronic diseases (such as ischemic stroke and diabetic microvascular complications) and providing clinicians with intuitive and scientific decision-making assistance.

[0169] S4. Based on the blood rheology test results and auxiliary diagnostic conclusions, automatically generate a blood circulation improvement diet plan, a meridian metabolism regulation plan, and a complete nutrition guidance plan, and integrate and output a comprehensive blood rheology analysis report.

[0170] The blood circulation improvement diet plan is generated based on six dietary assessment models and four nutritional guidance methods. The software system on the all-in-one machine 7 inputs the user's physiological and hemorheological indicators into the six assessment models, calculates a comprehensive risk score, triggers corresponding nutritional guidance strategies, and finally matches ingredients from the database.

[0171] The specific method for generating a diet plan to improve blood circulation is as follows.

[0172] Data acquisition and preprocessing: Acquire user data such as age, gender, BMI, blood lipids, blood glucose, blood pressure, and uric acid, as well as core data such as whole blood low-shear viscosity and erythrocyte aggregation index obtained from blood rheology detection.

[0173] Six dietary assessment models were run to calculate the risk score for dyslipidemia. Blood glucose abnormality risk score Blood pressure abnormality risk score High uric acid risk score Microcirculation Disorder Risk Score and oxidative stress risk score .

[0174] Match 4 nutritional guidance methods: Based on the score combination, match the following guidance methods: ① Low-fat, low-sodium (for , ); ② Low sugar and high fiber (for ); ③ Antioxidant / blood-activating and stasis-removing (targeting , ); ④ High-quality protein / low-purine (for ).

[0175] Generate quantitative recipes: Based on the matched nutritional guidance, set the target intake of daily macronutrients (carbohydrates, protein, and fat), and search the preset "food and medicine homology" and healthy food database for ingredients that meet the constraints to generate quantitative recipes that include the weight of breakfast, lunch, and dinner.

[0176] Among them, the risk score of dyslipidemia The comprehensive assessment of the degree of exceedance of total cholesterol, triglycerides, low-density lipoprotein (LDL) (positive indicator), and high-density lipoprotein (HDL) (negative indicator) is calculated using the following formula:

[0177] (14);

[0178] in, , , , These represent the measured values ​​of total cholesterol, triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol, respectively. This is the deviation function for the corresponding indicator. , , , These represent the weighting coefficients of each indicator (set by the system's built-in clinical nutrition guidelines, such as...). (The weight is usually the highest). Linkage strategy: when... When the threshold is exceeded, a "low-fat, low-cholesterol" nutrition guidance method will be applied.

[0179] Blood glucose abnormality risk score Used to assess the level of fasting blood glucose and glycated hemoglobin, reflecting short-term and long-term glucose metabolism risk, the calculation formula is as follows:

[0180] (15);

[0181] in, This is the measured value of fasting blood glucose. This represents the measured value of glycated hemoglobin. and For weighting coefficients. Linkage strategy: When When the threshold is exceeded, the "low sugar, high dietary fiber" nutritional guidance method will be matched.

[0182] Blood pressure risk is typically determined by the most significant deviation between systolic and diastolic blood pressure; therefore, a strategy of taking the largest value or a weighted fusion is employed. Blood Pressure Abnormality Risk Score The calculation formula is:

[0183] (16);

[0184] in, This is the measured value of systolic blood pressure (high pressure). This is the measured value of diastolic blood pressure (low pressure). , These are weighting coefficients. Linkage strategy: When the threshold is exceeded, the "low sodium, high potassium" nutrition guidance method will be matched.

[0185] Assessing blood uric acid levels requires automatically applying different reference thresholds based on the user's gender (typically >420 μmol / L for men and >360 μmol / L for women), and generating a high uric acid risk score. The calculation formula is:

[0186] (17);

[0187] in, This represents the measured value of blood uric acid. This is a dynamically applied upper limit for normal uric acid levels based on the user's gender. Linkage strategy: When... When the threshold is exceeded, the "low-purine high-quality protein" nutritional guidance method will be matched.

[0188] Microcirculation Disorder Risk Score The formula is calculated based on the hemorheological low-shear viscosity and aggregation index:

[0189] (18);

[0190] in, This is for the actual measurement of whole blood low-shear viscosity. This represents the upper limit of the reference range for low-shear viscosity of whole blood. This is for the actual measurement of the erythrocyte aggregation index. This represents the upper limit of the reference range for the erythrocyte aggregation index. , This is a weighting coefficient, set by the system default or the doctor, e.g., 0.5 for both. Linked strategy: Microcirculation disorder risk score. The higher the level, the more likely it is to match the nutritional guidance of "③ Antioxidant / Blood Circulation Improvement".

[0191] Oxidative stress lacks a single direct indicator in routine physical examinations. This system provides an indirect, comprehensive assessment using inflammatory factors (homocysteine, high-sensitivity C-reactive protein) combined with age-related aging factors. Oxidative stress risk score. The calculation formula is:

[0192] (19);

[0193] in, This represents the measured value of homocysteine ​​(a marker of oxidative damage to the vascular endothelium). This represents the measured value of high-sensitivity C-reactive protein (a marker of systemic micro-inflammation / oxidative stress). This is the user's actual age. The baseline age set for the system (e.g., 80 years old) is used to calculate the basic oxidation risk associated with age. , and For weighting coefficients. Linkage strategy: When When the threshold is exceeded, the nutritional guidance mode of "rich in antioxidants (such as vitamin C / E, anthocyanins)" will be matched.

[0194] The above scores ~ The core logic of the calculation is as follows: obtain the user's routine biochemical / physiological indicators, calculate the degree to which they deviate from the normal reference range (deviation degree), and convert them into a quantified risk score (e.g., 0-100 points) through a weighted algorithm. The system automatically triggers corresponding nutritional guidance strategies based on the score.

[0195] Before calculating each score, the all-in-one machine 7 first normalizes the input physiological indicators.

[0196] For indicators where "higher is more dangerous" (such as blood sugar, blood pressure, uric acid, etc.), the deviation of the indicator is:

[0197] (20);

[0198] For indicators where "lower is more dangerous" (such as high-density lipoprotein), the deviation of the indicator is:

[0199] (twenty one);

[0200] in These are the actual measured values ​​of the indicators. This represents the normal upper or lower limit for this indicator.

[0201] The objective function constrained by the comprehensive nutritional intervention (used for recipe generation) is:

[0202] (twenty two);

[0203] in For the recipe The actual calculated content of each nutrient The first set according to the matched nutritional guidance method Target limits for various nutrients (such as low sodium guidelines) ≤2000mg). This refers to the number of different types of nutrients (such as protein, fat, sodium, purines, etc.). This indicates taking the minimum value.

[0204] The meridian metabolism regulation program is based on the theory of the twelve meridians in traditional Chinese medicine. It integrates current blood rheology test results, environmental temperature and humidity data, and the user's innate physical characteristics to calculate the meridian metabolism blockage index and output targeted regulation strategies to reduce blood viscosity.

[0205] Specifically, this application maps hemorheological indicators from modern medicine to the syndromes of "blood stasis / qi deficiency / phlegm turbidity" in traditional Chinese medicine. Combining environmental factors (external pathogens) and physical constitution (internal factors), it calculates the "blockage index" of each of the twelve meridians and outputs conditioning strategies based on the "meridian flow" theory. The specific process is as follows.

[0206] Indicator-Meridian Mapping: Mapping abnormal blood rheology indicators to specific meridians. For example, high whole blood high shear viscosity / high erythrocyte rigidity index (reflecting thick blood and arteriosclerosis) is mapped to "blood stasis in the Heart / Liver Meridian"; high plasma viscosity (reflecting high blood lipids / blood sugar and internal phlegm) is mapped to "phlegm turbidity in the Spleen Meridian".

[0207] Environment and constitution correction: Obtain current environmental temperature and humidity data to calculate the "external pathogen index"; obtain the user's innate constitution (such as Qi deficiency constitution, blood stasis constitution) to calculate the "internal susceptibility coefficient".

[0208] Calculate the meridian blockage index: Based on the above three dimensions, calculate the blockage index for each of the twelve meridians. Metabolic blockage index of meridians Calculation formula:

[0209] (twenty three);

[0210] in, For the first The first hemorheological abnormality index for the first The pathological mapping weights of each meridian are preset by the TCM expert knowledge base. For example, the weight of the red blood cell rigidity index for the Heart Meridian is 0.8, and for the Spleen Meridian it is 0.2. For the first The degree of abnormality of each hemorheological parameter (the percentage of the measured value deviating from the reference value). This represents the number of abnormal hemorheological indicators. This is an environmental severity index, for example, when the temperature is below 15℃ and the humidity is above 70%. An increase in the value indicates that "cold and dampness stagnation" is aggravating meridian blockage. For users' innate physical condition to the first The susceptibility coefficient of a meridian, such as for users with "blood stasis constitution," their heart meridian and liver meridian... The value is 1.2, while the value for other meridians is 1.0. and The coefficients for adjusting environmental and physical conditions (e.g., both are taken as 0.5). For the first The metabolic blockage index of a meridian. ∈{1,2...12} corresponds to the twelve meridians, and the larger the value, the more severe the blockage.

[0211] Output conditioning strategies: Select the top N meridians with the highest blockage index, combine them with the "current meridian" of the current time, and output conditioning strategies such as acupoint massage, meridian tapping, or specific tea drinks (such as hawthorn and cassia seed tea to clear the liver meridian).

[0212] The comprehensive nutrition guidance program integrates dietary intervention and meridian regulation suggestions to form a daily quantitative diet and a multidimensional health management pathway.

[0213] Specifically, this application integrates spatial nutritional intake (recipe) with temporal meridian regulation (meridian flow) to generate a dynamic health management path with a timeline. The specific methods and steps are as follows.

[0214] Construct a timeline model: Divide the 24 hours of a day into 12 two-hour periods, corresponding to the "dominant" time of the twelve meridians (such as the gallbladder meridian being dominant at midnight and the liver meridian being dominant at 1-3 am).

[0215] Generate multi-dimensional intervention nodes:

[0216] Dietary nodes: The generated quantitative diet is allocated to specific time points in the morning, noon, and evening;

[0217] Meridian nodes: Insert meridian conditioning tasks one hour before or during the calculated "auspicious time" of the meridian with high blockage index (e.g., if the liver meridian has a high blockage index, arrange "pushing the liver meridian" or drinking liver-soothing tea before the Chou hour).

[0218] Path conflict detection and optimization: If the diet node conflicts with the meridian node (such as not eating before bed), fine-tuning is performed according to priority (usually meridian regulation has a higher priority than snacks).

[0219] Output dynamic path: Generate a daily check-in path that includes time, task type (diet / exercise / physiotherapy), and specific content to be performed, and supports dynamic adjustment based on user feedback.

[0220] Among them, the time matching priority function of multidimensional health management path :

[0221] (twenty four);

[0222] in, For a moment The need for dietary interventions, such as at mealtimes, A sudden increase. For time matching functions; when time... In the first When the meridian is in its ruling time (or 1 hour before its ruling time), =1, otherwise =0. Indicates at time Intervention is carried out only on the meridian with the largest "product of blockage index and time matching degree" among all meridians. , Weighting coefficients for diet and meridian therapy; such as =0.4, =0.6, highlighting the importance of meridian unblocking in the treatment of chronic diseases. For at any time The system assigns priority scores to health intervention tasks and generates timeline tasks based on these scores, from highest to lowest.

[0223] Through the calculation of the meridian metabolic blockage index, the all-in-one machine 7 can transform abstract blood rheology physical indicators into concrete TCM meridian conditioning instructions, realizing the digital integration of modern blood rheology and traditional TCM meridian theory, thereby providing users with a more accurate and personalized chronic disease intervention path.

[0224] This application integrates modern nutrition science (6 types of dietary assessments and 4 types of nutritional guidance) with the theory of the twelve meridians in Traditional Chinese Medicine. By combining environmental and physical constitution data to calculate the meridian metabolic blockage index, it achieves a leap from single medical testing to personalized, comprehensive health intervention programs, effectively improving patient compliance and the actual therapeutic effect of chronic disease intervention. The specific types of the aforementioned 6 dietary assessment models and 4 nutritional guidance methods, as well as the meridian mapping weight matrix, can be conventionally set by those skilled in the art based on clinical nutrition guidelines and TCM classics; this application does not impose a unique limitation on this.

[0225] The functional advantages of the fully automated hemorheology analyzer and its analysis method disclosed in this application are as follows.

[0226] Fully automated design: Adopting a one-click detection design, the system can automatically complete sampling, mixing, detection, and cleaning, and supports simultaneous detection of 40 samples. No manual operation is required during the process, which greatly reduces operating costs and error risks.

[0227] High-efficiency testing speed: The testing efficiency for both whole blood and plasma samples reaches ≥40 samples / hour, which can quickly meet the needs of batch testing, significantly improve the turnover efficiency of clinical testing, and shorten the waiting time for patients.

[0228] Automatic quality control calibration: Test parameters are automatically corrected by quality control materials, eliminating the need for manual calibration, reducing errors and ensuring accurate and stable test results.

[0229] Dual-mode operation: Flexible switching between color touchscreen and mouse / keyboard operation modes, combining the convenience and intuitiveness of touchscreen operation with the precision and efficiency of keyboard operation, adapting to the usage habits of different medical staff. A certain human-computer interaction interface is as follows: Figure 18 As shown.

[0230] Precise detection: Imported pressure sensing technology enables continuous dynamic shear monitoring, 1-200s. -1 It has a wide shear rate range to suit different populations; it can measure multiple core and derived indicators, providing comprehensive data; the test body has no moving parts, resulting in a low failure rate and long lifespan.

[0231] Highly efficient operation: Peripheral blood testing requires no special processing and provides results in 40 seconds; dedicated reagents reduce malfunctions, ensure accuracy, and are easy to use.

[0232] Intelligent System: The independently developed fully automated system automatically stores and analyzes data; when paired with a computer workstation, it supports printing A4 comprehensive reports, enhancing intelligence and report standardization.

[0233] Auxiliary Diagnosis and Treatment: We provide daily recommended diet plans to improve blood circulation, meridian metabolism regulation plans to improve blood circulation, and comprehensive nutritional guidance plans, achieving multi-dimensional management throughout the entire process. Comprehensive nutritional guidance offers 6 dietary assessments and 4 nutritional guidance methods to achieve full-process nutritional management. Based on blood rheology test results and in conjunction with physician decisions, we generate recommended diet plans to improve blood circulation. Based on the theory of the twelve meridians in Traditional Chinese Medicine, we analyze test results, environmental factors, and congenital data to generate the optimal meridian metabolism regulation plan, reducing blood viscosity and improving vascular patency through metabolic regulation.

[0234] This application discloses a fully automated blood rheology analyzer employing third-generation pressure sensing technology. A pump assembly applies decreasing pressure to a closed fluid path to drive blood flow. No moving mechanical parts within the testing body (syringe barrel and related fluid paths) come into contact with the blood, achieving a zero-mechanical-wear design. This not only avoids damage to red blood cells from mechanical shear forces, significantly improving detection accuracy, but also significantly reduces equipment failure rate and extends service life. Furthermore, this application highly integrates the aspiration assembly, upright plate assembly, and pump valve control onto a large base plate assembly, resulting in a compact structure. This enables high-throughput, fully automated, one-button testing of 40 samples, significantly reducing manual operation costs and the risk of error.

[0235] This application presents a fully automated hemorheological analysis method that combines multi-indicator combination logic to accurately determine the causes of abnormal blood viscosity, enabling auxiliary diagnosis of chronic diseases such as coronary heart disease and diabetes, as well as differentiation of physiological / pathological changes. Furthermore, this application establishes a closed loop of "detection-diagnosis-intervention," automatically generating blood circulation improvement diets, meridian metabolism regulation, and comprehensive nutritional guidance programs, providing multi-dimensional health management support for chronic diseases in middle-aged and elderly individuals, and enhancing the clinical application value of the equipment.

[0236] Those skilled in the art will understand that all or part of the software modules in the instruments / methods of the above embodiments can be implemented by hardware related to computer program instructions. The computer program can be stored in a non-volatile computer-readable storage medium, and when executed, it can implement the module functions as described in the system embodiments above. Any reference to memory or other media in the embodiments provided in this application can include at least one of non-volatile and volatile memory. Non-volatile memory may include read-only memory (ROM), magnetic tape, floppy disk, flash memory, optical memory, high-density embedded non-volatile memory, resistive random access memory (ReRAM), magnetic random access memory (MRAM), ferroelectric random access memory (FRAM), phase change memory (PCM), graphene memory, etc. Volatile memory may include random access memory (RAM) or external cache memory, etc. By way of illustration and not limitation, RAM can take many forms, such as Static Random Access Memory (SRAM) or Dynamic Random Access Memory (DRAM).

[0237] It should be noted that the information (including but not limited to user device information, user personal information, etc.) and data (including but not limited to data used for analysis, data stored, data displayed, etc.) involved in this application are all information and data authorized by the user or fully authorized by all parties, and the collection, use and processing of the relevant data must comply with relevant regulations.

[0238] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0239] This document uses specific examples to illustrate the principles and implementation methods of this application. The descriptions of the above embodiments are only for the purpose of helping to understand the methods and core ideas of this application. Furthermore, those skilled in the art will recognize that, based on the ideas of this application, there will be changes in the specific implementation methods and application scope. Therefore, the content of this specification should not be construed as a limitation of this application.

Claims

1. A fully automated hemorheology analyzer, characterized in that, include: Housing assembly and base plate assembly; The housing assembly includes a housing and an integrated unit; the integrated unit is fixed to the housing. The large base plate assembly is fixed inside the housing assembly. The large base plate assembly includes a large base plate component and, fixed to the large base plate component, a liquid suction component, a vertical plate component, a mounting bracket component, a power supply component, a pump component, a pipe connector component, and a circuit interface component. The liquid suction component enables automatic rotation of the measuring disc orifice and linear movement of the suction needle (forward, backward, up, and down). The vertical plate component enables liquid pressure detection and liquid heating. The circuit board in the mounting bracket component controls the liquid flow direction and the movement of the suction needle and measuring disc. The power supply component supplies power to the internal circuitry and drives the motor. The pump component controls the liquid suction volume. The pipe connector component connects the internal and external pipes. The circuit interface component connects the internal and external circuits. During operation, blood samples are introduced into the syringe and related fluid paths of the upright plate assembly through the aspiration component, forming a closed fluid path system. A specific initial pressure is applied to the sealed fluid path by the pump assembly, driving the blood to flow within the tube. During the flow, the circuit board controls the pressure to continuously decrease. Due to the continuous pressure change, the flow rate of the blood sample also changes accordingly. The pressure sensor in the upright plate assembly collects the pressure change curve over time during the pressure decrease process in real time and transmits it to the integrated machine, which calculates and outputs a comprehensive blood rheology analysis report.

2. The fully automated hemorheology analyzer according to claim 1, characterized in that, The liquid suction assembly includes: a mounting base plate, a slide rail column, a horizontal slide rail assembly, a vertical slide rail assembly, a cleaning tube, a cleaning tube fixing bend plate, a measuring plate assembly, a limit sensor, and a limit sensor fixing bend plate; The slide rail column is fixed to the mounting base plate; the horizontal slide rail assembly is fixed to the slide rail column; the vertical slide rail assembly is fixed to the slider of the horizontal slide rail assembly; the cleaning pipe is fixed to the cleaning pipe fixing bend plate, and the cleaning pipe fixing bend plate is fixed to the horizontal slide rail assembly; the measuring disc assembly is fixed to the mounting base plate; the limit sensor is installed on the limit sensor fixing bend plate, and the limit sensor fixing bend plate is fixed to the mounting base plate.

3. The fully automated hemorheology analyzer and its analysis method according to claim 1, characterized in that, The upright plate assembly includes: a sample bottle bottom plate, a sample bottle upright plate, a syringe straight connector, a syringe syringe, a pressure sensor, a pressure sensor bent plate, a first two-way solenoid valve, a sample bottle, a thermistor pressure plate, a thermistor, a second two-way solenoid valve, a first three-way solenoid valve, a heating shaft, and a heating shaft fixing bent plate. The sample bottle upright plate is fixed to the sample bottle bottom plate; the syringe straight connector is installed into the syringe barrel, and the flange fits; the syringe straight connector and the syringe barrel flange are installed into the rectangular hole of the sample bottle upright plate and fixed; the pressure sensor is fixed to the pressure sensor bent plate, and the pressure sensor bent plate is fixed to the sample bottle upright plate; the first two-way solenoid valve and the sample bottle are fixed to the sample bottle upright plate; the thermistor is installed into the heating shaft, the thermistor pressure plate is fixed on the heating shaft, the heating shaft is fixed to the heating shaft fixing bent plate, and the heating shaft fixing bent plate is fixed to the sample bottle upright plate; the second two-way solenoid valve and the first three-way solenoid valve are also fixed to the sample bottle upright plate.

4. The fully automated hemorheology analyzer and its analysis method according to claim 1, characterized in that, The fixing frame assembly includes: a fixing frame, a waste liquid bottle, a waste liquid bottle cap, a second three-way solenoid valve, a third three-way solenoid valve, a third two-way solenoid valve, a fourth three-way solenoid valve, a solenoid valve fixing bend plate, and a circuit board. The waste liquid bottle cap is inserted into the waste liquid bottle, and the flange is fitted; the flange of the waste liquid bottle and the waste liquid bottle cap are inserted into the rectangular hole of the fixing frame for fixation; the second three-way solenoid valve and the third three-way solenoid valve are fixed on the solenoid valve fixing plate, and the solenoid valve fixing plate is fixed on the fixing frame; the third two-way solenoid valve and the fourth three-way solenoid valve are also fixed on the solenoid valve fixing plate; the circuit board is fixed on the fixing frame.

5. The fully automated hemorheology analyzer and its analysis method according to claim 1, characterized in that, The pump assembly includes a peristaltic pump assembly, a pump isolation cover, a diaphragm pump, a diaphragm pump mounting plate, and shock-absorbing screws; One end of some of the shock-absorbing screws is fixed to the peristaltic pump assembly, and the other end is fixed to the base plate assembly with a nut; the diaphragm pump is fixed to the diaphragm pump mounting plate; one end of another set of shock-absorbing screws is fixed to the diaphragm pump mounting plate, and the other end is fixed to the base plate assembly with a nut; the pump isolation cover is fixed to the base plate assembly.

6. An analytical method based on the fully automated hemorheology analyzer according to any one of claims 1-5, characterized in that, Performed by the all-in-one machine, including the following steps: Acquire the pressure-time curves collected in real time by a fully automated blood rheology analyzer during blood flow and calculate the corresponding flow velocity data; Based on pressure-flow rate data, the basic indicators of whole blood viscosity, plasma viscosity and erythrocyte sedimentation rate are calculated, and multiple derived indicators are generated through a preset conversion model. The multiple derived indicators include relative / reduced viscosity at each shear rate, erythrocyte aggregation / rigidity / deformation / electrophoresis index, blood yield stress and erythrocyte sedimentation rate equation K value. By comparing multiple derived indicators with preset clinical reference ranges and combining the logic of multiple indicator combinations, the cause of abnormal blood viscosity is determined, and auxiliary diagnostic conclusions for the target chronic disease and suggestions for distinguishing between physiological and pathological changes are output. Based on the results of blood rheology testing and auxiliary diagnostic conclusions, the system automatically generates a blood circulation improvement diet plan, a meridian metabolism regulation plan, and a comprehensive nutrition guidance plan, and integrates and outputs a comprehensive blood rheology analysis report.

7. The analytical method according to claim 6, characterized in that, The process of acquiring the pressure-time curve collected in real time by the fully automated hemorheology analyzer during blood flow and calculating the corresponding flow velocity data specifically includes: according to Real-time absolute pressure value collected by the pressure sensor Using formula Calculate the average blood flow velocity ;in express The volume of the sealed air column above the syringe barrel at any given time; This represents the cross-sectional area of ​​the syringe barrel; This represents the derivative of pressure with respect to time, i.e., the pressure decay rate.

8. The analytical method according to claim 7, characterized in that, The calculation of baseline parameters for whole blood viscosity, plasma viscosity, and erythrocyte sedimentation rate based on pressure-flow rate data specifically includes: Using formula Calculate the shear stress on the blood ;in Indicates the inner radius of the syringe barrel; This indicates the pressure difference between the two ends of the syringe barrel; Indicates the effective length of the syringe barrel; Using formula Calculate the shear rate of blood. ;in Indicates instantaneous volumetric flow rate; Using formula Calculate the dynamic viscosity of blood ; As the pressure continues to decrease, based on real-time calculations... and This generates a continuous viscosity-shear rate curve; The viscosity values ​​of whole blood high / medium / low shear viscosity are obtained by extracting the average value of a specific shear rate point or interval from the viscosity-shear rate continuous curve. Calculated from blood samples at arbitrary shear rates Value as plasma viscosity; When a blood sample is at rest, the distance the red blood cell interface descends per unit time is measured as the erythrocyte sedimentation rate (ESR).

9. The analytical method according to claim 6, characterized in that, The process involves comparing multiple derived indicators with preset clinical reference ranges, combining multi-indicator combination logic to determine the cause of abnormal blood viscosity, and outputting auxiliary diagnostic conclusions for the target chronic disease, as well as prompts to differentiate between physiological and pathological changes. Specifically, this includes: When whole blood low-shear viscosity and erythrocyte aggregation index are significantly elevated, it indicates the risk of microcirculatory perfusion disorder and can help predict coronary heart disease and ischemic stroke. When whole blood high shear viscosity is abnormal and erythrocyte rigidity index is associated with metabolic indicators, it can aid in the diagnosis of diabetic microvascular complications. When the viscosity of all shear rates in whole blood increases and is accompanied by abnormal red blood cell count, it may be a sign of polycythemia vera. By establishing a time-series comparison model between individual baseline data and dynamic monitoring trends, physiological hemoconcentration and pathological hyperviscosity can be distinguished, which can be used to assist in early screening of chronic diseases, efficacy monitoring and intervention evaluation.

10. The analytical method according to claim 6, characterized in that, The blood circulation improvement diet plan is generated based on matching 6 dietary assessment models and 4 nutritional guidance methods; the meridian metabolism regulation plan is based on the theory of the twelve meridians in traditional Chinese medicine, and integrates current blood rheology test results, environmental temperature and humidity data and the user's innate physical characteristics to calculate the meridian metabolism blockage index and output targeted regulation strategies to reduce blood viscosity; the comprehensive nutrition guidance plan integrates dietary intervention and meridian regulation suggestions to form a daily quantitative diet and a multi-dimensional health management path.

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