New forms of ambrocenide®

A method transforms unpurified Ambrocenide into a crystalline, particulate form by molten treatment and cooling, addressing handling challenges and reducing costs by eliminating purification and solvent use, achieving comparable fragrance quality.

EP4558593B1Active Publication Date: 2025-11-12SYMRISE GMBH & CO KG
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Patent Information

Application Number
EP2023738687
Authority / Receiving Office
EP · EP
Patent Type
Patents
Current Assignee / Owner
Filing Date
2023-07-04
Publication Date
2025-11-12
Estimated Expiration
2043-07-04

AI Technical Summary

Technical Problem

Ambrocenide, a powerful fragrance substance, is challenging to handle due to its amorphous state and requires costly purification methods like solvent recrystallization, leading to yield losses and high manufacturing costs, while its use in dipropylene glycol solutions is not optimal due to high solvent content.

Method used

A method involving heating an unpurified synthesis product to a molten state, treating it with a solvent like water to evaporate impurities, and cooling it on a cold surface to form a solid particulate product, eliminating the need for purification steps and solvent use.

Benefits of technology

The method produces a crystalline, particulate form of Ambrocenide with identical olfactive properties to highly purified products, offering easy handling and low production costs without yield loss.

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Abstract

The present invention primarily relates to a method for producing a particulate product comprising or consisting of the steps as described herein. The invention further relates to a particulate product, preferably obtained or obtainable by a method as described herein, comprising 70 to 98 wt.-% compound of formula (la) as defined herein and 0.01 to 5 wt.-% compound of formula (lb) as defined herein, and to the use of a particulate product as described herein as a fragrance.
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