Method for producing a milk-like product

JP2024539934A5Pending Publication Date: 2025-10-31SOCIETE DES PRODUITS NESTLE SA
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Patent Information

Application Number
JP2024524421
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2021-10-27
Filing Date
2022-10-27
Publication Date
2025-10-31

AI Technical Summary

Technical Problem

Current methods for producing human milk are limited by the scarcity of human donors, regulatory constraints, and the inability of existing infant formulas to replicate the complex composition of human breast milk, particularly in terms of bioactive substances like lactoferrin, long chain polyunsaturated fatty acids, and oligosaccharides.

Method used

A method involving the culture of mammalian induced pluripotent stem cells (miPSCs) in a medium containing bone morphogenetic protein 4 (BMP4) to generate embryoid bodies, which are then differentiated into mammary gland cells and lactocytes, producing mammalian milk-like products, such as human milk-like products, through the use of mammary gland organoids.

Benefits of technology

This method enables the production of human milk-like products that mimic the composition of breast milk, including bioactive substances, and can be tailored to meet the specific nutritional needs of infants, offering a sustainable and customizable alternative to breast milk.

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Abstract

A method for producing mammary cells, and a method for producing a mammalian milk-like product, such as a human milk-like product, comprising generating lactocytes derived from mammalian induced pluripotent stem cells (miPSCs), such as from human induced pluripotent stem cells (hiPSCs), and expressing the mammalian milk-like product, such as the human milk-like product, from the lactocytes.
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