Preventing, and suppressing progression of, retinal disease, improving visual cognitive behavioral function, and strengthening visual function
A chimeric protein of ion-transporting and G-protein-coupled rhodopsins, encoded by nucleic acid, addresses the limitations of current retinal disease treatments by preventing progression and enhancing visual functions like light-dark discrimination and visual acuity.
JP2025109855APending Publication Date: 2025-07-25RESTORE VISION CO LTD
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Patent Information
- Application Number
- JP2025080665
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Filing Date
- 2025-05-13
- Publication Date
- 2025-07-25
AI Technical Summary
Technical Problem
Current treatments for retinal diseases such as retinitis pigmentosa are ineffective in preventing or slowing down disease progression, and there is a need for improved methods to enhance visual cognitive behavioral functions and visual acuity.
Method used
A chimeric protein composed of an ion-transporting rhodopsin and a G-protein-coupled receptor rhodopsin, administered through nucleic acid encoding, is used to prevent retinal disease progression and enhance visual functions like light-dark discrimination and visual acuity.
Benefits of technology
The chimeric protein effectively suppresses retinal disease progression and improves visual cognitive behavioral functions, including light-dark discrimination and visual acuity, even when administered before symptom onset.
✦ Generated by Eureka AI based on patent content.
Abstract
To provide prevention and suppression of progression of retinal diseases, improvement in visual cognitive behavioral function, and strengthening of visual function.SOLUTION: A chimeric protein of two types of rhodopsins, an ion-transporting rhodopsin and a G protein-coupled receptor rhodopsin, and a nucleic acid encoding the chimeric protein are provided for the prevention and suppression of progression of retinal diseases, improvement in visual cognitive behavioral functions (e.g., improvement in light-dark determination functions, improvement in bright spot evading functions, and / or crisis avoidance functions), and enhancement of visual functions (e.g., improvement in visual acuity). The present invention also provides a method for preventing or suppressing progression of a disease, disorder or symptom of the retina, for improving a visual cognitive behavioral function (e.g., improvement in light-dark determination functions, improvement in bright spot evading functions, and / or crisis avoidance functions), or for enhancing visual functions (e.g., improvement in visual acuity), in a subject. The method comprises the step of administering an effective amount of a nucleic acid encoding a chimeric protein of an ion-transporting receptor rhodopsin and a G protein-coupled receptor rhodopsin to the subject.SELECTED DRAWING: None
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