Pharmaceutical compositions for staining membranes and other biological structures using a natural or synthetic CBD-based vital dye isolated and / or associated with other dyes for vitreoretinal surgery

AU2024438884A1Pending Publication Date: 2026-10-15VICADIA LDA
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Patent Information

Application Number
AU2024438884
Authority / Receiving Office
AU · AU
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-04-01
Filing Date
2024-04-04
Publication Date
2026-10-15

AI Technical Summary

Technical Problem

Current vital dyes used in vitreoretinal surgery, such as ICG, BBG, and TB, face challenges with toxicity, lack of specificity, and postoperative complications, complicating the visualization and removal of semi-transparent biological membranes and structures, leading to potential retinal damage and oxidative stress.

Method used

The use of a natural or synthetic CBD-based vital dye, associated with dyes like BBG and TB, provides targeted delivery and enhanced staining with anti-inflammatory and antioxidant properties, minimizing toxicity and protecting tissues from surgical light damage.

Benefits of technology

The CBD-based dye enhances visualization and safety during surgical procedures by providing precise staining with reduced toxicity, protecting ocular tissues and reducing recovery time and complications.

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Abstract

The present invention describes the use of a pharmaceutical compositions for dyeing or staining membranes and other biological structures using a natural or synthetic CBD-based vital dye isolated and / or associated with other dyes, namely BBG and / or TB, as a promising approach during surgical or medical procedures, such as vitreoretinal. The use of such compounds for the preparation of dyeing or staining compositions in order to facilitate their identification and biomolecular membrane composition, results in the visualization of different types of ocular membranes and tissues along with the cellular and tissue protection from damage induced by the exposition to surgical light. The present invention describes the entirety process, since the production of the composition purpose along with formulation and studies conducted, until the purport method for staining biological membranes and structures to improve their adequate identification and manipulation, responding to the challenged presented by the complexity of the surgical procedure mainly chromovitrectomy.
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