Hyaluronic acid-based compositions and dry eye treatment

Abstract

New crosslinked hyaluronic acid gels are provided and use of same as canalicular occlusive devices and to treat dry eye disease. In one aspect, a composition for ocular administration is provided comprising a therapeutically effective amount of 1) crosslinked hyaluronic acid and 2) uncrosslinked hyaluronic acid, wherein the composition has i) a cohesivity value of at least 3 mg according to the drop weight method and ii) a G' elastic modulus of less than 400 Pa.