Thiophene analogues for the treatment or prevention of flavivirus infections

By developing thiophene compounds with specific substitutions as HCV polymerase inhibitors, the problems of limited efficacy and significant side effects in existing treatments for flavivirus infections have been solved, achieving more effective viral inhibition and prevention.

CN102675279AInactive Publication Date: 2012-09-19VIROCHEM PHARMA INC (CA)
44 Cites 0 Cited by

Patent Information

Application Number
CN201210081280.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2006-11-15
Filing Date
2007-11-15
Publication Date
2012-09-19
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

Existing drugs for treating flavivirus infections, especially hepatitis C virus (HCV) infection, have limited efficacy and significant side effects, necessitating the development of more effective antiviral drugs.

Method used

A new class of thiophene compounds is provided, which, as HCV polymerase inhibitors, exhibit improved antiviral activity through specific substitution design for the treatment or prevention of flavivirus infections.

Benefits of technology

These compounds exhibit excellent potential for treating and preventing hepatitis C infection, possessing improved properties, effectively inhibiting viral polymerase activity, and reducing side effects.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The present invention relates to hiophene analogues for the treatment or prevention of flavivirus infections, specifically to compounds represented by formula IA or pharmaceutically acceptable salts and solvates thereof which are useful for treating flaviviridae viral infections wherein R1 is C1-6 alkyl or C3-6 cycloalkyl; X is M is R5 is cyclohexyl which is unsubstituted or substituted one or more times by R13; R6 is or cyclohexyl which is substituted in the 4 position by R14; and Y, R14a and R14 are as defined herein.
Need to check novelty before this filing date? Find Prior Art